EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 5, 2004, Pages 2390-2396

  Daftary, Gaurang S ^a   Taylor, Hugh S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SEX HORMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EMX2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; FEMALE GENITAL SYSTEM; GENE EXPRESSION; HOX GENE; HOXA10 GENE; HUMAN; HUMAN TISSUE; MENSTRUAL CYCLE; PRIORITY JOURNAL; REPORTER GENE; STROMA CELL;

ADULT; BINDING SITES; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; GENE EXPRESSION; GENITALIA, FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MENSTRUAL CYCLE; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; STROMAL CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 2442526172     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031389     Document Type: Article

References (60)

1. McGinnis W, Krumlauf R 1992 Homeobox genes and axial patterning. Cell 68:283-302
2. Akam M 1989 Hox and HOM: homologous gene clusters in insects and vertebrates. Cell 57:347-349
3. Favier B, Dolle P 1997 Developmental functions of mammalian Hox genes. Mol Hum Reprod 3:115-131
4. Morata G, Sanchez-Herrero E 1999 Patterning mechanisms in the body trunk and the appendages of Drosophila. Development 126:2823-2828
5. Ferrier DE, Holland PW 2001 Ancient origin of the Hox gene cluster. Nat Rev Genet 2:33-38
6. Taylor HS, Vanden Heuvel GB, Igarashi P 1997 A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 57:1338-1345
7. Block K, Kardana A, Igarashi P, Taylor HS 2000 In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system. FASEB J 14:1101-1108
8. Krumlauf R 1994 Hox genes in vertebrate development. Cell 78:191-201
9. Bagot CN, Troy PJ, Taylor HS 2000 Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Ther 7:1378-1384
10. Satokata I, Benson G, Maas R 1995 Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature 374:460-463
11. Benson GV, Lim H, Paria BC, Satokata I, Dey SK, Maas RL 1996 Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development 122:2687-2696
12. Taylor HS, Arici A, Olive D, Igarashi P 1998 HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest 101:1379-1384
13. Troy PJ, Daftary GS, Bagot CN, Taylor HS 2003 Transcriptional repression of Peri-implantation EMX2 expression in mammalian reproduction by HOXA10. Mol Cell Biol 23:1-13
14. Grossniklaus U, Cadigan KM, Gehring WJ 1994 Three maternal coordinate systems cooperate in the patterning of the Drosophila head. Development 120:3155-3171
15. Dalton D, Chadwick R, McGinnis W 1989 Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo. Genes Dev 3:1940-1956
16. Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E 1994 Chromosome locations of human EMX and OTX genes. Genomics 22:41-45
17. Boncinelli E, Gulisano M, Broccoli V 1993 Emx and Otx homeobox genes in the developing mouse brain. J Neurobiol 24:1356-1366
18. Walldorf U, Gehring WJ 1992 Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development. EMBO J 11:2247-2259
19. Pellegrini M, Mansouri A, Simeone A, Boncinelli E, Gruss P 1996 Dentate gyrus formation requires Emx2. Development 122:3893-3898
20. Yoshida M, Suda Y, Matsuo I, Miyamoto N, Takeda N, Kuratani S, Aizawa S 1997 Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124:101-111
21. Simeone A, Gulisano M, Acampora D, Stornaiuolo A, Rambaldi M, Boncinelli E 1992 Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J 11:2541-2550
22. Simeone A, Acampora D, Gulisano M, Stornaiuolo A, Boncinelli E 1992 Nested expression domains of four homeobox genes in developing rostral brain. Nature 358:687-690
23. Miyamoto N, Yoshida M, Kuratani S, Matsuo I, Aizawa S 1997 Defects of urogenital development in mice lacking Emx2. Development 124:1653-1664
24. Noonan FC, Goodfellow PJ, Staloch LJ, Mutch DG, Simon TC 2003 Antisense transcripts at the EMX2 locus in human and mouse. Genomics 81:58-66
25. Taylor HS, Bagot C, Kardana A, Olive D, Arici A 1999 HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod 14:1328-1331
26. 1985 Revised American Fertility Society classification of endometriosis: 1985. Fertil Steril 43:351-352
27. Noyes RW, Hertig AT, Rock J 1950 Dating the endometrial biopsy. Fertil Steril 1:3-5
28. Nishida M, Kasahara K, Kaneko M, Iwasaki H, Hayashi K 1985 [Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors]. Nippon Sanka Fujinka Gakkai Zasshi 37:1103-1111
29. Lessey BA, Ilesanmi AO, Castelbaum AJ, Yuan L, Somkuti SG, Chwalisz K, Satyaswaroop PG 1996 Characterization of the functional progesterone receptor in an endometrial adenocarcinoma cell line (Ishikawa): progesterone-induced expression of the α1 integrin. J Steroid Biochem Mol Biol 59:31-39
30. Hata H, Kuramoto H 1992 Immunocytochemical determination of estrogen and progesterone receptors in human endometrial adenocarcinoma cells (Ishikawa cells). J Steroid Biochem Mol Biol 42:201-210
31. Daftary GS, Troy PJ, Bagot CN, Young SL, Taylor HS 2002 Direct regulation of β3-integrin subunit gene expression by HOXA10 in endometrial cells. Mol Endocrinol 16:571-579
32. Taylor HS 1998 A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins. Mol Reprod Dev 49:246-253
33. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O 1993 Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 90:11162-11166
34. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery Jr CA, Shyamala G, Conneely OM, O'Malley BW 1995 Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 9:2266-2278
35. Korach KS 1994 Insights from the study of animals lacking functional estrogen receptor. Science 266:1524-1527
36. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M 2000 Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127:4277-4291
37. Wheeler JM 1989 Epidemiology of endometriosis-associated infertility. J Reprod Med 34:41-46
38. Barnhart K, Dunsmoor-Su R, Coutifaris C 2002 Effect of endometriosis on in vitro fertilization. Fertil Steril 77:1148-1155
39. Arici A, Oral E, Bukulmez O, Duleba A, Olive DL, Jones EE 1996 The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program. Fertil Steril 65:603-607
40. Ayers JW, Birenbaum DL, Menon KM 1987 Luteal phase dysfunction in endometriosis: elevated progesterone levels in peripheral and ovarian veins during the follicular phase. Fertil Steril 47:925-299
41. Halme J, Becker S, Haskill S 1987 Altered maturation and function of peritoneal macrophages: possible role in pathogenesis of endometriosis. Am J Obstet Gynecol 156:783-789
42. Witz CA, Montoya IA, Dey TD, Schenken RS 1994 Characterization of lymphocyte subpopulations and T cell activation in endometriosis. Am J Reprod Immunol 32:173-179
43. Mills MS, Eddowes HA, Cahill DJ, Fahy UM, Abuzeid MI, McDermott A, Hull MG 1992 A prospective controlled study of in-vitro fertilization, gamete intra-fallopian transfer and intrauterine insemination combined with super-ovulation. Hum Reprod 7:490-494
44. Fedele L, Marchini M, Bianchi S, Dorta M, Arcaini L, Fontana PE 1990 Structural and ultrastructural defects in preovulatory endometrium of normo-ovulating infertile women with minimal or mild endometriosis. Fertil Steril 53:989-993
45. Lessey BA, Castelbaum AJ 1995 Integrins in the endometrium of women with endometriosis. Br J Obstet Gynaecol 102:347-348
46. Lessey BA, Young SL 1997 Integrins and other cell adhesion molecules in endometrium and endometriosis. Semin Reprod Endocrinol 15:291-299
47. Ota H, Igarashi S, Hatazawa J, Tanaka T 1997 Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil Steril 68:23-28
48. Osteen KG, Bruner KL, Sharpe-Timms KL 1996 Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis. Semin Reprod Endocrinol 14:247-255
49. Sharpe-Timms KL 1997 Basic research in endometriosis. Obstet Gynecol Clin North Am 24:269-290
50. Sillem M, Prifti S, Monga B, Buvari P, Shamia U, Runnebaum B 1997 Soluble urokinase-type plasminogen activator receptor is over-expressed in uterine endometrium from women with endometriosis. Mol Hum Reprod 3:1101-1105
51. Fujimoto J, Ichigo S, Hirose R, Sakaguchi H, Tamaya T 1997 Expression of estrogen receptor wild type and exon 5 splicing variant mRNAs in normal and endometriotic endometria during the menstrual cycle. Gynecol Endocrinol 11:11-16
52. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN 1996 Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrin Metab 81:3112-3118
53. Bartosik D, Damjanov I, Viscarello RR, Riley JA 1987 Immunoproteins in the endometrium: clinical correlates of the presence of complement fractions C3 and C4. Am J Obstet Gynecol 156:11-15
54. Tseng JF, Ryan IP, Milam TD, Murai JT, Schriock ED, Landers DV, Taylor, RN 1996 Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis. J Clin Endocrin Metab 81:1118-1122
55. Cermik D, Selam B, Taylor HS 2003 Regulation of HOXA-10 expression I testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome. J Clin Endocrinol Metab 88:238-243
56. Daftary GS, Taylor HS 2002 Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression. Fertil Steril 78:577-580
57. Daftary GS, Taylor HS 2004 Pleiotropic effects of Hoxa10 on the functional development of peri-implantation endometrium. Mol Reprod Dev 67:8-14
58. Daftary GS, Taylor HS 2001 Molecular markers of implantation: clinical implications. Curr Opin Obstet Gyn 13:269-274
59. Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ 2001 Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers. Genomics 76:37-44
60. Daftary GS, Taylor HS 2001 Efficient liposome-mediated gene transfection and expression in the intact human uterus. Hum Gene Ther 12:2121-2127