Radiation-induced up-regulation of Mmp2 involves increased mRNA stability, redox modulation, and MAPK activation

Radiation Research

Volumn 161, Issue 4, 2004, Pages 418-429

  Zhao, Weiling ^a   Goswami, Prabhat C ^b   Robbins, Mike E C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; ANTIOXIDANT; DACTINOMYCIN; EBSELEN; GELATINASE A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; 1,3 BUTADIENE DERIVATIVE; COMPLEMENTARY DNA; ENZYME INHIBITOR; FLAVONOID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; PUROMYCIN; RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE; GENETIC TRANSFECTION; INCUBATION TIME; IRRADIATION; KIDNEY TUBULE CELL; MMP2 GENE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION EXPOSURE; RAT; RNA STABILITY; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOLOGY; DOMINANT GENE; EPITHELIUM CELL; KIDNEY TUBULE; KINETICS; METABOLISM; MUTATION; NORTHERN BLOTTING; OXIDATIVE STRESS; PHOSPHORYLATION; RADIATION RESPONSE; TIME; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BUTADIENES; CELL LINE; CELLS, CULTURED; DACTINOMYCIN; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; FLAVONOIDS; GENES, DOMINANT; KIDNEY TUBULES; KINETICS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NITRILES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PUROMYCIN; RATS; RNA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 2442446069     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/3155     Document Type: Article

References (49)

1. T. H. Vu and Z. Werb, Matrix metalloproteinases: Effectors of development and normal physiology. Genes Dev. 14, 2123-2133 (2000).
2. H. Nagase and J. F. Woessner, Matrix metalloproteinases. J. Biol. Chem. 274, 21491-21494 (1999).
3. C. Lafuma, R. Azzi El Nabout, F. Crechet, A. Hovnanian and M. Martin, Expression of 72-kDa gelatinase (MMP-2), collagenase (MMP-1), and tissue metalloproteinase inhibitor (TIMP) in primary pig skin fibroblast cultures derived from radiation-induced skin fibrosis. J. Invest. Dermatol. 102, 945-950 (1994).
4. R. C. Benyon, C. J. Hovell, M. Da Gaca, E. H. Jones, J. P. Iredale and M. J. Arthur, Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation. Hepatology 30, 977-986 (1999).
5. W. Zhao, Y. O'Malley and M. E. C. Robbins, Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis. Radiat. Res. 152, 160-169 (1999).
6. W. Zhao, Y. O'Malley, S. Wei and M. E. C. Robbins, Irradiation of rat tubule epithelial cells alters the expression of gene products associated with the synthesis and degradation of extracellular matrix. Int. J. Radiat. Biol. 76, 391-402 (2000).
7. J. Araya, M. Maruyama, K. Sassa, T. Fujita, R. Hayashi, S. Matsui, T. Kashi, N. Yamashita, E. Sugiyama and M. Kobayashi, Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 280, L30-L38 (2001).
8. H. P. Hartung and B. C. Kieseier, The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system. J. Neuroimmunol. 107, 140-147 (2000).
9. M. L. Coker, C. V. Thomas, M. J. Clair, J. W. Hendrick, R. S. Krombach, Z. S. Galis and F. G. Spinale, Myocardial matrix metalloproteinase activity and abundance with congestive heart failure. Am. J. Physiol. Heart Circ. Physiol. 274, H1516-H1523 (1998).
10. T. Hayashi, W. G. Stetler-Stevenson, M. V. Fleming, N. Fishback, M. N. Koss, L. A. Liotta, V. J. Ferrans and W. D. Travis, Immunohistochemical study of matrix metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis. Am. J. Pathol. 149, 1241-1256 (1996).
11. S. Milani, H. Herbst, D. Schuppan, C. Grappone, G. Pellegrini, M. Pinzani, A. Casini, A. Calabro, G. Ciancio and F. Stefanini, Differential expression of matrix metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am. J. Pathol. 144, 528-537 (1994).
12. T. Takahara, K. Furui, J. Funaki, Y. Nakayama, H. Itoh, C. Miyabayashi, H. Sato and M. Seiki, Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats. Hepatology 21, 787-795 (1995).
13. R. E. Swiderski, J. E. Dencoff, C. S. Floerchinger, S. D. Shapiro and G. W. Hunninghake, Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 152, 821-828 (1998).
14. I. M. Dixon, H. Ju, N. L. Reid, T. Scammel-La Fleur, J. P. Werner and G. Jasmin, Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan. J. Mol. Cell. Cardiol. 29, 1837-1850 (1997).
15. T. Shimizu, T. Kuroda, S. Hata, M. Fukagawa, S. B. Margolin and K. Kurokawa, Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. Kidney Int. 54, 99-109 (1998).
16. M. M. Mozes, E. P. Bottinger, T. A. Jacot and J. B. Kopp, Renal expression of fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) in TGF-beta transgenic mice. J. Am. Soc. Nephrol. 10, 271-280 (1999).
17. K. Steinmann-Niggli, R. Ziswiler, M. Kung and H. P. Marti, Inhibition of matrix metalloproteinases attenuates anti-Thy1.1 nephritis. J. Am. Soc. Nephrol. 9, 397-407 (1998).
18. M. E. Fini, J. R. Cook, R. Mohan and C. E. Brinckerhoff, Regulation of matrix metalloproteinase gene expression. In Matrix Metalloproteinases (W. C. Parks and R. P. Mecham, Eds.), pp. 299-356. Academic Press, San Diego, CA, 1998.
19. A. Mauviel, Y. Q. Chen, V. M. Kahari, I. Ledo, M. Wu, L. Rudnicka and J. Uitto, Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. J. Biol. Chem. 268, 6520-6524 (1993).
20. C. Ries and P. E. Petrides, Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease. Biol. Chem. Hoppe Seyler 376, 345-355 (1995).
21. Y. Kawaguchi, H. Tanaka, T. Okada, H. Konishi, M. Takahashi, M. Ito and J. Asai, The effects of ultraviolet light and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts. Arch. Dermatol. 288, 39-44 (1996).
22. D. A. Siwik, P. J. Pagano and W. S. Colucci, Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am. J. Physiol. Cell. Physiol. 280, C53-C60 (2001).
23. 2 exposure. Lab. Invest. 77, 533-539 (1997).
24. R. Sawaya, P. J. Tofilon, S. Mohanam, F. Alli-Osman, L. A. Liotta, W. G. Stetler-Stevenson and J. S. Rao, Induction of tissue-type plasminogen activator and 72-kDa type IV collagenase by ionizing radiation in rat astrocytes. Int. J. Cancer 56, 214-218 (1994).
25. C. Nirmala, S. L. Jasti, R. Sawaya, A. P. Kryitsis, S. D. Konduri, F. Ali-Osman, J. S. Rao and S. Mohanam, Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions. Int. J. Cancer 88, 766-771 (2000).
26. P. A. Riley, Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 65, 27-33 (1994).
27. W. Zhao, D. R. Spitz, L. W. Oberley and M. E. C. Robbins, Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. Cancer Res. 61, 5537-5543 (2001).
28. K. Hensley, K. A. Robinson, S. P. Gabbita, S. Salsman and R. A. Floyd, Reactive oxygen species, cell signaling, and cell injury. Free Radic. Biol. Med. 28, 1456-1462 (2000).
29. T. Tong, W. Fan, H. Zhao, S. Jin, F. Fan, P. Blanck, L. Alomo, B. Rajasekaran, Y. Liu and Q. Zhan, Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation. Exp. Cell Res. 269, 64-72 (2001).
30. A. Gupta, S. F. Rosenberger and G. T. Bowden, Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 20, 2063-2073 (1993).
31. J. Bian and Y. Sun, Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol. Cell. Biol. 17, 330-6338 (1997).
32. C. A. Beelman and R. Parker, Degradation of mRNA in eukaryotes. Cell 81, 179-183 (1995).
33. J. Ross, Control of messenger RNA stability in higher eukaryotes. Trends Genet. 12, 171-175 (1996).
34. J. S. Malter and Y. Hong, A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore. J. Biol. Chem. 266, 3167-3171 (1991).
35. P. C. Goswami, J. Sheren, L. D. Albee, A. Parsian, J. E. Sim, L. A. Ridnour, R. Higashikubo, D. Gius and D. R. Spitz, Cell cycle-coupled variation in topoisomerase IIα mRNA is regulated by the 3′-untranslated region. J. Biol. Chem. 275, 38384-38392 (2000).
36. Y. Ben-Yosef, N. Lahat, S. Shapiro, H. Bitterman and A. Miller, Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation. Circ. Res. 90, 784-791 (2002).
37. E-S. Akool, H. Kleinert, F. M. A. Hamada, M. H. Abdelwahab, U. Forstermann, J. Pfeilschifter and W. Eberhardt, Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR. Mol. Cell. Biol. 23, 4901-4916 (2003).
38. M. Anbar and P. Neta, A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution. Int. J. Appl. Radiat. Isot. 18, 495-523 (1967).
39. Z. S. Galis, K. Asanuma, D. Godin and X. Meng, N-Acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: New target for antioxidant therapy? Circulation 97, 2445-2453 (1998).
40. T. Schewe, Molecular actions of ebselen-an antiinflammatory antioxidant. Gen. Pharmacol. 26, 1153-1169 (1995).
41. C. A. Lambert, A. C. Colige, C. Munaut, C. M. Lapiere and B. V. Nusgens, Distinct pathways in the over-expression of matrix metalloproteinases in human fibroblasts by relaxation of mechanical tension. Matrix Biol. 20, 397-408 (2001).
42. T. Shearer and C. E. Crosson, Activation of extracellular signal-regulated kinase in trabecular meshwork cells. Exp. Eye Res. 73, 25-35 (2001).
43. D. R. Welch, T. Sakamaki, R. Pioquinto, T. O. Leonard, S. F. Goldberg, Q. Hon, R. L. Erikson, M. S. Reiber and A. Alessandrini, Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase confers tumorogenic and metastatic potentials to NIH3T3 cells. Cancer Res. 60, 1552-1556 (2000).
44. H. Kurata, A. A. Thant, S. Matsuo, T. Senga, K. Okazaki, N. Hotta and M. Hamaguchi, Constitutive activation of MAP kinase (MEK 1) is critical and sufficient for the activation of MMP-2. Exp. Cell. Res. 254, 180-188 (2000).
45. A. Yacoub, J. S. Park, L. Qiao, P. Dent and M. P. Hagan, MAPK dependence of DNA damage repair; ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion. Int. J. Radiat. Biol. 77, 1067-1078 (2001).
46. K. Mori, M. Tani, K. Kamata, H. Kawamura, Y. Urata, S. Goto, M. Kuwano, S. Shibata and T. Kondo, Mitogen-activated protein kinase, ERK1/2, is essential for the induction of vascular endothelial growth factor by ionizing radiation mediated by activator protein-1 in human glioblastoma cells. Free Radic. Res. 33, 157-166 (2000).
47. S. Delanian, F. Baillet, J. Huart, J. L. Lefaix, C. Maulard and M. Housset, Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial. Radiother. Oncol. 32, 12-20 (1994).
48. J. L. Lefaix, S. Delanian, M-C. Vozenin, J. J. Leplat, Y. Tricaud and M. Martin, Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and α-tocopherol: An experimental study. Int. J. Radiat. Oncol. Biol. Phys. 43, 839-847 (1999).
49. M. W. Epperly, S. Defilippi, C. Sikora, J. Gretton and J. S. Greenberger, Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene. Mil. Med. 167 (Suppl.), 71-73 (2002).