Expression patterns of hedgehog signaling peptides in naturally acquired equine osteochondrosis

Journal of Orthopaedic Research

Volumn 23, Issue 5, 2005, Pages 1152-1159

  Semevolos, Stacy A ^a,b   Strassheim, M Lisa ^a   Haupt, Jennifer L ^a   Nixon, Alan J ^a  

^a Cornell University ^*  (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Cartilage; Development; Dyschondroplasia; Hedgehog; Osteochondrosis

Indexed keywords

MESSENGER RNA; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SIGNAL PEPTIDE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HORSE DISEASE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCHONDROSIS; PATELLOFEMORAL JOINT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SHOULDER; TISSUE DISTRIBUTION;

ANIMALS; DNA-BINDING PROTEINS; HEDGEHOG PROTEINS; HORSES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NERVE TISSUE PROTEINS; ONCOGENE PROTEINS; OSTEOCHONDRITIS; POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 24344509837     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2005.01.024     Document Type: Article

References (34)

1. H. Akiyama C. Shigeno Y. Hiraki et al. Cloning of a mouse Smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5 Bichem Biophys Res Commun 235 1997 142-147
2. P. Aza-Blanc H.-Y. Lin A.R. Altaba T.B. Kornberg Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities Development 127 2000 4293-4301
3. C.B. Bai A.L. Joyner Gli1 can rescue the in vivo function of Gli2 Development 128 2001 5161-5172
4. P. Bullough Joint diseases In: S. Steinberg editor. 3rd ed Diagnostic surgical pathology vol. 1 1999 Lippincott Williams & Wilkins Philadelphia
5. L. Buttitta R. Mo C.-C. Hui C.-M. Fan Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction Development 130 2003 6233-6243
6. D. Carpenter D.M. Stone J. Brush et al. Characterization of two patched receptors for the vertebrate hedgehog protein family Proc Natl Acad Sci USA 95 1998 13630-13634
7. J.K. Chen J. Taipale K.E. Young et al. Small molecule modulation of Smoothened activity Proc Natl Acad Sci USA 99 2002 14071-14076
8. U.I. Chung B. Lanske K. Lee et al. Parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation Proc Natl Acad Sci USA 95 1998 13030-13035
9. N. Denef D. Neubuser L. Perez S.M. Cohen Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened Cell 102 2000 521-531
10. M. Iwasaki A.X. Le J.A. Helms Expression of Indian hedgehog, bone morphogenetic protein 6 and Gli during skeletal morphogenesis Mech Dev 69 1997 197-202
11. L.B. Jeffcott Osteochondrosis in the horse - searching for the key to pathogenesis Equine Vet J 23 1991 331-338
12. L.B. Jeffcott F.M.D. Henson Studies on growth cartilage in the horse and their application to aetiopathogenesis of dyschondroplasia (osteochondrosis) Vet J 156 1998 177-192
13. R.L. Johnson M.P. Scott New players and puzzles in the hedgehog signaling pathway Curr Opin Genet Dev 8 1998 450-456
14. H. Juppner Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development Pediatr Nephrol 14 2000 606-611
15. S. Kawai T. Sugiura Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: Activation of BMP promoters by Gli, a Sonic hedgehog mediator Bone 29 2001 54-61
16. S. Laverty S. O'Kouneff M. Ionescu et al. Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis J Orthop Res 20 2002 1282-1289
17. V. Marigo M.P. Scott R.L. Johnson et al. Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb Development 122 1996 1225-1233
18. V. Martin G. Carrillo C. Torroja I. Guerrero The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking Curr Biol 11 2001 601-607
19. M. Murone A. Rosenthal F.J. de Sauvage Sonic hedgehog signaling by the Patched-Smoothened receptor complex Curr Biol 9 1999 76-84
20. T. Nakase T. Miyaji K. Kuriyama et al. Immunohistochemical detection of parathyroid hormone-related peptide, Indian hedgehog, and patched in the process of endochondral ossification in the human Histochem Cell Biol 116 2001 277-284
21. R.V. Pearse K.J. Vogan C.J. Tabin Ptc1 and Ptc2 transcripts provide distinct readouts of hedgehog signaling activity during chick embryogenesis Dev Biol 239 2001 15-29
22. K.A. Platt J. Michaud A.L. Joyner Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice Mech Dev 62 1997 121-135
23. R. Pool Difficulties in definition of equine osteochondrosis; differentiation of developmental and acquired lesions Equine Vet J Supp 16 1993 5-12
24. L. Sandell N. Morris J. Robbins M. Goldring Alternatively spliced type 2 procollagen mRNAs define distinct populations of cells during vertebral development: Differential expression of the amino-peptide J Cell Biol 114 1991 1307-1319
25. S.A. Semevolos B.D. Brower-Toland S.J. Bent A.J. Nixon Parathyroid hormone-related peptide and Indian hedgehog expression patterns in naturally acquired equine osteochondrosis J Orthop Res 20 2002 1290-1297
26. S.A. Semevolos A.J. Nixon B.D. Brower-Toland Changes in molecular expression of aggrecan and collagen types I, II, and X, insulin-like growth factor-I, and transforming growth factor-b1 in articular cartilage obtained from horses with naturally acquired osteochondrosis Am J Vet Res 62 2001 1088-1094
27. D.R. Stark Hedgehog signalling: Pulling apart Patched and Smoothened Curr Biol 12 2002 R437-R439
28. J. Taipale M.K. Cooper T. Maiti P.A. Breachy Patched acts catalytically to suppress the activity of Smoothened Nature 418 2002 897
29. B.C.J. van der Eerden M. Karperien E.F. Gevers et al. Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the post-natal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth J Bone Miner Res 15 2000 1045-1055
30. S. Volk P.S. Leboy Regulating the regulators of chondrocyte hypertrophy J Bone Min Res 14 1999 483-486
31. A. Vortkamp K. Lee B. Lanske et al. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein Science 273 1996 613-621
32. D. Walterhouse M. Ahmed D. Slusarski et al. gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development Dev Dyn 196 1993 91-102
33. J. Won Yoon Y. Kita D.J. Frank et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation J Biol Chem 277 2002 5548-5555
34. P.G. Zaphiropoulos A.B. Unden F. Rahnama et al. PTCH2, a novel human Patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas Cancer Res 59 1999 787-792