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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 20, 2005, Pages 4589-4593

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

(13) Chua, Peter C a Nagasawa, Johnny Y a Bleicher, Leo S a Munoz, Benito a Schweiger, Edwin J a Tehrani, Lida a Anderson, Jeffrey J b Cramer, Merryl a Chung, Janice a Green, Mitchell D a King, Chris D a Reyes Manalo, Grace a Cosford, Nicholas D P a

a MERCK RESEARCH LABORATORIES (United States)

b Merck Laboratories (United States)

Author keywords

Antagonist; CNS; mGlu5

Indexed keywords

METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; RECEPTOR OCCUPANCY; STRUCTURE ACTIVITY RELATION;

EXCITATORY AMINO ACID ANTAGONISTS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 24344439736 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.06.099 Document Type: Article

Times cited : (15)

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