Evaluation of a radiolabelled peripheral benzodiazepine receptor ligand in the central nervous system inflammation of experimental autoimmune encephalomyelitis: A possible probe for imaging multiple sclerosis

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 32, Issue 5, 2005, Pages 557-563

  Mattner, F ^a   Katsifis, A ^a   Staykova, M ^b   Ballantyne, P ^a   Willenborg, D O ^b  

^a AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^b The Australian National University   (Australia)

Author keywords

Experimental autoimmune encephalomyelitis; Inflammation; Multiple sclerosis; Peripheral benzodiazepine receptors; SPECT

Indexed keywords

6 CHLORO 2 (4' IODOPHENYL) 3 (N,N DIETHYL)IMIDAZO[1,2 A]PYRIDIN 3 ACETAMIDE I 123; BENZODIAZEPINE RECEPTOR; FREUND ADJUVANT; MYELIN BASIC PROTEIN; RADIOLIGAND; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CENTRAL NERVOUS SYSTEM DISEASE; CERVICAL SPINAL CORD; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DISEASE SEVERITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; LIGAND BINDING; LUMBAR SPINAL CORD; MACROPHAGE; MALE; MEDULLA OBLONGATA; MICROGLIA; MULTIPLE SCLEROSIS; MYCOBACTERIUM BUTYRICUM; NONHUMAN; RAT; RAT STRAIN; SACRAL SPINAL CORD; SPINAL CORD; THORACIC SPINAL CORD; UPREGULATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CARRIER PROTEINS; DRUG EVALUATION, PRECLINICAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEASIBILITY STUDIES; FREUND'S ADJUVANT; INFLAMMATION; ISOTOPE LABELING; MALE; METABOLIC CLEARANCE RATE; MULTIPLE SCLEROSIS; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEW; RECEPTORS, GABA-A; SPINAL CORD; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 24044500034     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-004-1690-y     Document Type: Article

References (25)

1. Papadopoulos V, Amri H, Li H, Yao Z, Brown RC, Vidic B, et al. Structure, function and regulation of the mitochondrial peripheral-type benzodiazepine receptor. Therapie 2001;56:549-56.
2. 3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem 1983; 41:1744-50.
3. Bono F, Lamarche I, Prabonnaud V, Le Fur G, Herbert JM. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities. Biochem Biophys Res Commun 1999;265:457-61.
4. Brown RC, Papadopoulos V. Role of the peripheral-type benzodiazepine receptor in adrenal and brain steroidogenesis. Int Rev Neurobiol 2001;46:117-43.
5. Li H, Yao Z, Degenhardt B, Teper G, Papadopoulos V. Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc Natl Acad Sci USA 2001;98:1267-72.
6. Culty M, Luo L, Yao ZX, Chen H, Papadopoulos V, Zirkin BR. Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl 2002;23:439-47.
7. Banati RB. Visualising microglial activation in vivo. Glia 2002;40:206-17.
8. Banati RB. Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain. Br Med Bull 2003;65:121-31.
9. Kuhlmann AC, Guilarte TR. Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity. J Neurochem 2000;74:1694-704.
10. Mankowski JL, Queen SE, Tarwater PJ, Adams RJ, Guilarte TR. Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis. J Neurovirol 2003;9:94-100.
11. Messmer K, Reynolds GP. Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease. Neurosci Lett 1998;241:53-6.
12. 11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain 2001;124:2014-27.
13. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, Heppner F, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000;123:2321-37.
14. Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, et al. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res 1997;50:345-53.
15. Bruck W, Sommermeier N, Bergmann M, Zettl U, Goebel HH, Kretzschmar HA, et al. Macrophages in multiple sclerosis. Immunobiology 1996;195:588-600.
16. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000;47:707-17.
17. Sobel RA. The pathology of multiple sclerosis. Neurol Clin 1995;13:1-21.
18. 3H]PK11195 binding to activated microglia. J Neurocytol 1997;26:77-82.
19. 123I]iodo-PK11195: a possible single-photon emission tomography tracer for visualization of inflammation. Eur J Nucl Med 1999;26:194-200.
20. 123I]imidazo[1,2-a]pyridines as potential probes for the study of the peripheral benzodiazepine receptors using SPECT. J Nucl Med 1998;39(5):50.
21. 123I]imidazo[1,2-a]pyridines as potential probes for the study of the peripheral benzodiazepine receptors using SPECT. Radiochim Acta 2000;88(3-4):229-32.
22. Eylar EH. The structure and immunologic properties of basic proteins of myelin. Ann N Y Acad Sci 1972;195:481-91.
23. 123I]-ClINDE in animal tumour models. J Lab Comp Radiopharm 2003;46:S9.
24. 123I]-labelled peripheral benzodiazepine receptor ligands in tumour bearing rodents. Eur J Nucl Med Mol Imaging 2002;29:S163.
25. 11C]PK11195. Eur J Neurol 2003;10:257-64.