A complex pattern of mutations and abnormal splicing of Smad4 is present in thyroid tumours

Oncogene

Volumn 24, Issue 34, 2005, Pages 5344-5354

  Lazzereschi, Davide ^a   Nardi, Francesco ^a   Turco, Alessandra ^a   Ottini, Laura ^a   D'Amico, Cristina ^b   Mariani Costantini, Renato ^b   Gulino, Alberto ^a   Coppa, Anna ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Abnormal splicing; Molecular pathology; Smad4; Somatic mutations; TGF signalling; Thyroid tumours

Indexed keywords

GENE PRODUCT; RNA; SMAD4 PROTEIN; DNA BINDING PROTEIN; SMAD4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ALTERNATIVE RNA SPLICING; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; EXON; GENE DELETION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; GENETIC LINKAGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MISSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA ANALYSIS; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; THYROID CANCER; THYROID TUMOR; GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALTERNATIVE SPLICING; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; HUMANS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMAD4 PROTEIN; THYROID NEOPLASMS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 24044432265     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208603     Document Type: Article

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