Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: Identification of seven novel somatic mutations in tumors from Japanese patients

Mutation Research - Mutation Research Genomics

Volumn 406, Issue 2-4, 1999, Pages 71-77

  Koyama, Masaaki ^a   Ito, Masahide ^a   Nagai, Hisaki ^b   Emi, Mitsuru ^b   Moriyama, Yuukichi ^a  

^a NIPPON MEDICAL SCHOOL MUSASHI KOSUGI HOSPITAL   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Colorectal cancer; DPC4 SMAD4; Tumor suppressor gene

Indexed keywords

DNA; TRANSFORMING GROWTH FACTOR BETA;

ALLELE; ARTICLE; CANCER INHIBITION; CHROMOSOME; COLORECTAL CANCER; CONTROLLED STUDY; GENE INACTIVATION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; JAPAN; JUVENILE POLYP; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ALLELES; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 18; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; JAPAN; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SMAD4 PROTEIN; TRANS-ACTIVATORS;

EID: 0032823144     PISSN: 13835726     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5726(99)00003-5     Document Type: Article

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