Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure

Immunology

Volumn 116, Issue 1, 2005, Pages 122-133

  Mohan, Joanne ^a   Hopkins, John ^a   Mabbott, Neil A ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

Dendritic cells; Langerhans cells; Scrapie; Skin; Transmissible spongiform encephalopathy

Indexed keywords

LIPOPOLYSACCHARIDE; PRION PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; IN VITRO STUDY; INFECTION; LANGERHANS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SCRAPIE AGENT; SKIN;

ANIMALS; ANTIGENS, SURFACE; BRAIN; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION; IMMUNOPHENOTYPING; LANGERHANS CELLS; LIPOPOLYSACCHARIDES; MICE; PRION DISEASES; PRPC PROTEINS; PRPSC PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN;

EID: 23944512381     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2005.02207.x     Document Type: Article

References (50)

1. Meyer RK, McKinley MP, Bowman KA, Braunfeld MB, Barry RA, Prusiner SB. Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci USA 1986; 83:2310-4.
2. Legname G, Baskakov IV, Nguyen H-OB, Riesner D, Cohen FE, DeArmond SJ, Prusiner SB. Synthetic mammalian prions. Science 2004; 305:673-6.
3. Taylor DM, McConnell I, Fraser H. Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice. J Gen Virol 1996; 77:1595-9.
4. Bartz JC, Kincaid AE, Bessen RA. Rapid prion neuroinvasion following tongue infection. J Virol 2003; 77:583-91.
5. Mohan J, Brown KL, Farquhar CF, Bruce ME, Mabbott NA. Scrapie transmission following exposure through the skin is dependent on follicular dendritic cells in lymphoid tissues. J Dermatol Sci 2004; 35:101-11.
6. Mohan J, Bruce ME, Mabbott NA. Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin. Immunology 2005; 114:225-34.
7. Mabbott NA, Mackay F, Minns F, Bruce ME. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat Med 2000; 6:719-20.
8. Montrasio F, Frigg R, Glatzel M, Klein MA, Mackay F, Aguzzi A, Weissmann C. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 2000; 288:1257-9.
9. Mabbott NA, Young J, McConnell I, Bruce ME. Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility. J Virol 2003; 77:6845-54.
10. Mabbott NA, Bruce ME, Botto M, Walport MJ, Pepys MB. Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie. Nat Med 2001; 7:485-7.
11. Klein MA, Kaeser PS, Schwarz P et al Complement facilitates early prion pathogenesis. Nat Med 2001; 7:488-92.
12. Kapasi ZF, Burton GF, Schultz LD, Tew JG, Szakal AK. Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. J Immunol 1993; 150:2648-58.
13. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767-811.
14. Wu S-JL, Grouard-Vogel G, Sun W et al Human skin Langerhans cells are targets of dengue virus infection. Nat Med 2000; 6:816-20.
15. Reece JC, Handley AJ, Anstee EJ, Morrison WA, Crowe SM, Cameron PU. HIV-1 selection by epidermal dendritic cells during transmission across human skin. J Exp Med 1998; 187:1623-31.
16. Sc from the gut. J Gen Virol 2002; 83:267-71.
17. Matsue H, Matsue K, Walters M, Okumura K, Yagita H, Takashima A. Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells. Nat Med 1999; 5:930-7.
18. Mohan J, Bruce ME, Mabbott NA. Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells. J Virol 2005; 79:1888-97.
19. Xu S, Ariizumi K, Caceres-Dittmar G, Edelbaum D, Hashimoto K, Bergstresser PR, Takashima A. Successive generation of antigen-presenting dendritic cell lines from murine epidermis. J Immunol 1995; 154:2697-705.
20. Zanusso G, Liu D, Ferrari S et al Prion protein expression in different species: analysis with a panel of new mAbs. Proc Natl Acad Sci USA 1998; 95:8812-6.
21. Bosque PJ, Prusiner SB. Cultured cell sublines highly suscpeptible to prion infection. J Virol 2000; 74:4377-86.
22. Enari M, Flechsig E, Weissmann C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci USA 2001; 98:9295-9.
23. Dickinson AG, Meikle VM, Fraser H. Genetical control of the concentration of ME7 scrapie agent in the brain of mice. J Comp Path 1969; 79:15-22.
24. Kimberlin RH, Walker CA. Intraperitoneal infection with scrapie is established within minutes of injection and is non-specifically enhanced by a variety of different drugs. Arch Virol 1990; 112:103-14.
25. Takeuchi J, Watari E, Shinya E et al. Down-regulation of Toll-like receptor expression in monocyte derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochem Biophys Res Commun 2003; 306:674-9.
26. Kaisho T, Akira S. Regulation of dendritic cell function through Toll-like receptors. Curr Mol Med 2003; 3:759-71.
27. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD 14 a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990; 249:1431-3.
28. + cell line (XS52) by IL-4, TNF-α, IL-1β, and agonistic anit-CD40 monoclonal antibody. J Immunol 1999; 163:5331-7.
29. Wykes M, Pombo A, Jenkins C, MacPherson GG. Dendritic cells interact directly with Naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J Immunol 1998; 161:1313-9.
30. Luhr KM, Wallin RPA, Ljunggren H-G, Löw P, Taraboulos A, Kristensson K. Processing and degradation of exogenous prion protein by CD11c+ myeloid dendritic cells in vitro. J Virol 2002; 76:12259-64.
31. + dendritic cells and GT1-neuronal cells. J Virol 2004; 78:4776-82.
32. Cumberbatch M, Dearman RJ, Kimber I. Langerhans cells require signals from both tumour necrosis factor-α and interleukin-1β for migration. Immunology 1997; 92:388-96.
33. Ban E, Dupré L, Hermann E, Rohn W, Vendeville C, Quatannens B, Ricciardi-Castagnoli P, Capron A, Riveau G. CpG motifs induce Langerhans cell migration in vivo. Int Immunol 2000; 12:737-45.
34. De Smedt T, Pajak B, Muraille L et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 1996; 184:1413-24.
35. Sethi S, Lipford G, Wagner H, Kretzschmar H. Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet 2002; 360:229-30.
36. Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med 2004; 10:187-92.
37. Prinz M, Heikenwalder M, Scwarz P, Takeda K, Akira S, Aguzzi A. Prion pathogenesis in the absence of Toll-like receptor signalling. EMBO Reports 2003; 4:195-9.
38. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 1995; 182:389-400.
39. Beringue V, Demoy M, Lasmezas CI et al. Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis. J Pathol 2000; 190:495-502.
40. Schuler G, Steinman RM. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 1985; 161:526-46.
41. Inaba K, Witmer-Pack M, Inaba M et al. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 1994; 180:1849-60.
42. Cumberbatch M, Peters SW, Gould SJ, Kimber I. Intracellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritc cells: comparison with epidermal Langerhans cells. Immunol Lett 1992; 32:105-10.
43. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity. Trends Immunol 2002; 23:445-9.
44. 106-126 induces a NF-κB-driven proinflammatory response in human monocyte-derived dendritic cells. J Leukoc Biol 2003; 74:118-25.
45. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nature Rev Immunol 2002; 2:77-84.
46. Caughey B, Raymond GJ, Ernst D, Race RE. N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of the conversion of PrP to the protease-resistant state. J Virol 1991; 65:6597-603.
47. Sc in prion-infected cells. J Biol Chem 2002; 277:38972-7.
48. Heller U, Winklhofer KF, Heske J, Reintjes A, Tatzeit J. Posttranslational import of the prion protein into the endoplasmic reticulum interferes with cell viability. J Biol Chem 2003; 278:36139-47.
49. Porter DD, Porter HG, Cox NA. Failure to demonstrate a humoral immune response to scrapie infection in mice. J Immunol 1973; 111:1407-10.
50. Fraser H, Bruce ME, Davies D, Farquhar CF, McBride PA. The lymphoreticular system in the pathogenesis of scrapie. In: Prusiner, SB, Collinge, J, Powell, J, Anderton, B, eds. Prion Diseases of Humans and Animals. Chichester: Ellis Harwood Ltd, 1992:309-17.