Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line

Apoptosis

Volumn 10, Issue 5, 2005, Pages 1175-1186

  Skvortsov, S ^a,c   Skvortsova, I ^a   Sarg, B ^a   Loeffler Ragg, J ^a   Lindner, H ^a   Lukas, P ^a   Tabernero, J ^b   Zwierzina, H ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Apoptosis; Colorectal cancer cell; EGFR; EGFR TKI; Proteomics

Indexed keywords

CANERTINIB; CASPASE; CATHEPSIN D; EPIDERMAL GROWTH FACTOR RECEPTOR; LEUKOCYTE ELASTASE INHIBITOR; PROTEIN BAX; PROTEOME;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MASS SPECTROMETRY; MITOCHONDRION; NUCLEOTIDE SEQUENCE; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CACO-2 CELLS; CASPASE 3; CASPASES; CATHEPSIN D; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; GENES, TUMOR SUPPRESSOR; HUMANS; MORPHOLINES; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINAZOLINES; RECEPTOR, ERBB-2; SERPINS;

EID: 23944506632     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-005-1322-4     Document Type: Article

References (50)

1. Ciardiello F, Kim N, Saeki T, et al. Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci USA 1991; 88: 7792-7796.
2. Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000; 19: 6550-6565.
3. Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-345.
4. Wu X, Fan Z, Masui H, Rosen N, Mendelsohn J. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest 1995; 95: 1897-1905.
5. Liu B, Fang M, Schmidt M, Lu Y, Mendelsohn J, Fan Z. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 2000; 82: 1991-1999.
6. Mandal M, Adam L, Mendelsohn J, Kumar R. Nuclear targeting of Bax during apoptosis in human colorectal cancer cells. Oncogene 1998; 17: 999-1007.
7. Slichenmyer WJ, Elliott WL, Fry DW CI-1033, a pan-erbB tyrosine kinase inhibitor. Semin Oncol 2001; 28: 80-85.
8. Calvo E, Tolcher AW, Hammond LA, et al. Administration of CI-1033, an Irreversible Pan-erbB Tyrosine Kinase Inhibitor, Is Feasible on a 7-Day On, 7-Day Off Schedule: A Phase I Pharmacokinetic and Food Effect Study. Clin Cancer Res 2004; 10: 7112-7120.
9. Allen LF, Eiseman IA, Fry DW, Lenehan PF. CI-1033, an irreversible pan-erbB receptor inhibitor and its potential application for the treatment of breast cancer. Semin Oncol 2003; 30: 65-78.
10. Murakami M, Sasaki T, Yamasaki S, Kuwahara K, Miyata H, Chayama K. Induction of apoptosis by ionizing radiation and CI-1033 in HuCCT-1 cells. Biochem Biophys Res Commun 2004; 319: 114-119.
11. Nelson JM, Fry DW. Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition. J Biol Chem 2001; 276: 14842-14847.
12. Rao GS, Murray S, Ethier SP. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. Int J Radiat Oncol Biol Phys 2000; 48: 1519-1528.
13. Olive M, Untawale S, Coffey RJ, et al. Characterization of the DiFi rectal carcinoma cell line derived from a familial adenomatous polyposis patient. In Vitro Cell Dev Biol 1993; 29A: 239-248.
14. Ott HW, Lindner H, Sarg B, et al. Calgranulins in cystic fluid and serum from patients with ovarian carcinomas. Cancer Res 2003; 63: 7507-7514.
15. Bonomi P. Clinical studies with non-iressa EGFR tyrosine kinase inhibitors. Lung Cancer 2003; 41(Suppl 1): S43-S48.
16. Nyati MK, Maheshwari D, Hanasoge S, et al. Radiosensitization by pan ErbB inhibitor CI-103 3 in vitro and in vivo. Clin Cancer Res 2004; 10: 691-700.
17. Skvortsov S, Sarg B, Loeffler-Ragg J, et al. Different proteome pattern of epidermal growth factor receptor-positive colorectal cancer cell lines that are responsive and nonresponsive to C225 antibody treatment. Mol Cancer Ther 2004; 3: 1551-1558.
18. Chang GC, Hsu SL, Tsai JR, et al. Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells. Biochem Pharmacol 2004; 68: 1453-1464.
19. Donovan M, Cotter TG. Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta 2004; 1644: 133-147.
20. Loeffler M, Daugas E, Susin SA, et al. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J 2001; 15: 758-767.
21. Cande C, Cohen I, Daugas E, et al. Apoptosis-inducing factor (AIF): A novel caspase-independent death effector released from mitochondria. Biochimie 2002; 84: 215-222.
22. Cheung EC, Melanson-Drapeau L, Cregan SP, et al. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 2005; 25: 1324-1334.
23. Campiglio M, Locatelli A, Olgiati C, et al. Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level. J Cell Physiol 2004; 198: 259-268.
24. Torriglia A, Perani P, Brossas JY, et al. L-DNase II, a molecule that links proteases and endonucleases in apoptosis, derives from the ubiquitous serpin leukocyte elastase inhibitor. Mol Cell Biol 1998; 18: 3612-3619.
25. Torriglia A, Chaudun E, Chany-Fournier F, Jeanny JC, Courtois Y, Counis MF. Involvement of DNase II in nuclear degeneration during lens cell differentiation. J Biol Chem 1995; 270: 28579-28585.
26. Brossas JY, Tanguy R, Brignole-Baudouin F, Courtois Y, Torriglia A, Treton J. L-DNase II associated with active process during ethanol induced cell death in ARPE-19. Mol Vis 2004; 10: 65-73.
27. Torriglia A, Negri C, Chaudun E, et al. Differential involvement of DNases in HeLa cell apoptosis induced by etoposide and long term-culture. Cell Death Differ 1999; 6: 234-244.
28. Leist M, Jaattela M. Triggering of apoptosis by cathepsins. Cell Death Differ 2001; 8: 324-326.
29. Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003; 4: 416-423.
30. Zang Y, Beard RL, Chandraratna RA, Kang JX. Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. Cell Death Differ 2001; 8: 477-485.
31. Kagedal K, Zhao M, Svensson I, Brunk UT. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 2001; 359: 335-343.
32. Bidere N, Lorenzo HK, Carmona S, et al. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 2003; 278: 31401-31411.
33. Zou Z, Anisowicz A, Hendrix MJ, et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 1994; 263: 526-529.
34. Liu J, Yin S, Reddy N, Spencer C, Sheng S. Bax mediates the apoptosis-sensitizing effect of maspin. Cancer Res 2004; 64: 1703-1711.
35. Jiang N, Meng Y, Zhang S, Mensah-Osman E, Sheng S. Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene 2002; 21: 4089-4098.
36. Nakamura K, Bossy-Wetzel E, Burns K, et al. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J Cell Biol 2000; 150: 731-740.
37. 2+, and calcineurin - signaling from the endoplasmic reticulum. Mol Cells 2004; 17: 383-389.
38. Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 2000; 12: 1539-1546.
39. Ou SH, Wu F, Harrich D, Garcia-Martinez LF, Gaynor RB. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol 1995; 69: 3584-3596.
40. Buratti E, Dork T, Zuccato E, Pagani F, Romano M, Baralle FE. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J 2001; 20: 1774-1784.
41. Strong TV, Wilkinson DJ, Mansoura MK, et al. Expression of an abundant alternatively spliced form of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is not associated with a cAMP-activated chloride conductance. Hum Mol Genet 1993; 2: 225-230.
42. Kim JA, Kang YS, Lee SH, Lee EH, Yoo BH, Lee YS. Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cells. Biochem Biophys Res Commun 1999; 261: 682-688.
43. DeMartino GN, Slaughter CA. The proteasome, a novel protease regulated by multiple mechanisms. J Biol Chem 1999; 274: 22123-22126.
44. Murata S, Kawahara H, Tohma S, et al. Growth retardation in mice lacking the proteasome activator PA28gamma. J Biol Chem 1999; 274: 38211-38215.
45. Jungmann RA, Huang D, Tian D. Regulation of LDH-A gene expression by transcriptional and posttranscriptional signal transduction mechanisms. J Exp Zool 1998; 282: 188-195.
46. de Graaf TW, de Jong S, de Vries EG, Mulder NH. Expression of proteins correlated with the unique cisplatin-sensitivity of testicular cancer. Anticancer Res 1997; 17: 369-375.
47. Jurisic V, Bumbasirevic V, Konjevic G, Djuricic B, Spuzic I. TNF-alpha induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin's lymphomas. Ann Hematol 2004; 83: 84-91.
48. Creutz CE. The annexins and exocytosis. Science 1992; 258: 924-931.
49. Tonini R, Ferroni A, Valenzuela SM, et al. Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells. FASEB J 2000; 14: 1171-1178.
50. Valenzuela SM, Mazzanti M, Tonini R, et al. The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. J Physiol 2000; 529(Pt 3): 541-552.