Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthesized dogs: Actual versus predicted values

British Journal of Anaesthesia

Volumn 94, Issue 1, 2005, Pages 49-56

  Ezzine, S ^a   Varin, France ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Model, dog; Pharmacokinetics, rocuronium; Pharmacology, rocuronium

Indexed keywords

PENTOBARBITAL; ROCURONIUM;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG INFUSION; DRUG MUSCLE LEVEL; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; HINDLIMB; INTERSTITIAL FLUID; JUGULAR VEIN; MALE; MICRODIALYSIS; NEUROMUSCULAR FUNCTION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RELIABILITY; STEADY STATE; STIMULATION;

EID: 11344255809     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aei005     Document Type: Article

References (22)

1. Holford NH, Sheiner LB. Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 1981; 6: 429-53
2. Proost JH, Mirakhur RK, Eriksson LI, Roest J, Wierda JM. Urinary, biliary and faecal excretion of rocuronium in humans. Br J Anaesth 2000; 85: 717-23
3. Ali HH, Savarese JJ. Monitoring of neuromuscular function. Anesthesiology 1976; 45: 216-49
4. Ezzine S, Varin F. Determination of interstitial rocuronium concentrations in the muscle tissue of anesthetized dogs by microdialysis. J Pharmacol Toxicol Methods 2004; 49: 121-9
5. Bouw MR, Hammarlund-Udenaes M. Methodological aspects of the use of a calibrator in in vivo microdialysis - further development of the retrodialysis method. Pharm Res 1998; 15: 1673-9
6. Ducharme J, Varin F, Bevan DR, Donati F, Theoret Y. High-performance liquid chromatography-electrochemical detection of vecuronium and its metabolites in human plasma. J Chromatogr 1992; 573: 79-86
7. Cameron M, Donati F, Varin F. In vitro plasma protein binding of neuromuscular blocking agents in different subpopulations of patients. Anesth Analg 1995; 81: 1019-25
8. Hartley HO. The modified Gauss-Newton method for fitting of non-linear regression functions by least squares. Technometrics 1961; 3: 269-80
9. Davies M, Whitting I. Modified Form of Levenberg's Correction. Numerical Methods for Non-linear Optimization. London: Academic Press, 1972
10. Gibaldi M, Perrier D. Pharmacokinetics. In: Gibaldi M, Perrier D, eds. Pharmacokinetics. New York: Marcel Dekker, 1982; 273-9
11. Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther 1979; 25: 358-71
12. Holford NH, Sheiner LB. Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 1981; 6: 429-53
13. Dragne A, Varin F, Plaud B, Donati F. Rocuronium pharmacokinetic-pharmacodynamic relationship under stable propofol or isoflurane anesthesia. Can J Anaesth 2002; 49: 353-60
14. Marshall RJ, Muir AW, Sleigh T, Savage DS. An overview of the pharmacology of rocuronium bromide in experimental animals. Eur J Anaesthesiol Suppl 1994; 9: 9-15
15. Wierda JM, Proost JH, Schiere S, Hommes FD. Pharmacokinetics and pharmacokinetic/dynamic relationship of rocuronium bromide in humans. Eur J Anaesthesiol Suppl 1994; 9: 66-74
16. Plaud B, Proost JH, Wierda JM et al. Pharmacokinetics and pharmacodynamics of rocuronium at the vocal cords and the adductor pollicis in humans. Clin Pharmacol Ther 1995; 58: 185-91
17. Nolting A, Costa TD, Vistelle R, Rand KH, Derendorf H. Determination of free extracellular concentrations of piperacillin by microdialysis. J Pharm Sci 1996; 85: 369-72
18. Kovar A, Dalla CT, Derendorf H. Comparison of plasma and free tissue levels of ceftriaxone in rats by microdialysis. J Pharm Sci 1997; 86: 52-6
19. Sasongko L, Ramzan I, Williams KM, McLachlan AJ. Muscle distribution of the neuromuscular blocker gallamine using microdialysis. J Pharm Sci 2002; 91: 769-75
20. De La Pena A, Dalla CT, Talton JD et al. Penetration of cefaclor into the interstitial space fluid of skeletal muscle and lung tissue in rats. Pharm Res 2001; 18: 1310-4
21. Roy J, Varin F. Physicochemical properties of neuromuscular blocking agents and their impact on the PK-PD relation. Br J Anaesth 2004; 93: 1-8
22. Fuchs-Buder T, Strowitzki M, Rentsch K et al. Concentrations of rocuronium in cerebrospinal fluid of patients undergoing cerebral aneurysm clipping. Br J Anaesth 2004; 92: 419-21