메뉴 건너뛰기




Volumn 289, Issue 3 58-3, 2005, Pages

Age-specific changes in the regulation of LH-dependent testosterone secretion: Assessing responsiveness to varying endogenous gonadotropin output in normal men

Author keywords

Aging; Androgen; Gonadotropin releasing hormone; Luteinizing hormone; Male; Secretion

Indexed keywords

ALBUMIN; GANIRELIX; GONADORELIN ANTAGONIST; GONADOTROPIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

EID: 23944463647     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00138.2005     Document Type: Article
Times cited : (13)

References (67)
  • 1
    • 3643130143 scopus 로고    scopus 로고
    • A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (Puregon)
    • The ganirelix dose-finding study group
    • The Ganivelix Dose-Finding Study Group. A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (Puregon). The ganirelix dose-finding study group. Hum Reprod 13: 3023-3031, 1998.
    • (1998) Hum Reprod , vol.13 , pp. 3023-3031
  • 2
    • 0031594725 scopus 로고    scopus 로고
    • Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-D-aspartate
    • Bonavera JJ, SwerdlolT RS, Sinha Hakim AP, Lue YH, and Wang C. Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-D-aspartate. J Neuroendocrinol 10: 93-99, 1998.
    • (1998) J Neuroendocrinol , vol.10 , pp. 93-99
    • Bonavera, J.J.1    Swerdlolt, R.S.2    Sinha Hakim, A.P.3    Lue, Y.H.4    Wang, C.5
  • 3
    • 0021274804 scopus 로고
    • Age-related difference in the effect of castration upon hypothalamic LHRH content in male rat
    • Bourguignon JP, Gerard A, and Franchimont P. Age-related difference in the effect of castration upon hypothalamic LHRH content in male rat. Neuroendocrinology. 38: 376-381, 1984.
    • (1984) Neuroendocrinology , vol.38 , pp. 376-381
    • Bourguignon, J.P.1    Gerard, A.2    Franchimont, P.3
  • 4
    • 0029828126 scopus 로고    scopus 로고
    • In vivo bioactivities and clearance patterns of highly purified luteinizing hormone isoforms
    • Burgon PG, Stanton PG, and Robertson DM. In vivo bioactivities and clearance patterns of highly purified luteinizing hormone isoforms. Endocrinology 137: 4827-4836, 1996.
    • (1996) Endocrinology , vol.137 , pp. 4827-4836
    • Burgon, P.G.1    Stanton, P.G.2    Robertson, D.M.3
  • 5
    • 0033592972 scopus 로고    scopus 로고
    • Long-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging
    • Chen H and Zirkin BR. Long-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging. Proc Natl Acad Sci USA 96: 14877-14881, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14877-14881
    • Chen, H.1    Zirkin, B.R.2
  • 6
    • 33645477736 scopus 로고
    • Testicular function and neuroendocrine activity in senescent mice
    • Chubb CE and Desjardins C. Testicular function and neuroendocrine activity in senescent mice. Am J Physiol Endocrinol Metab 247: E410-E415, 1984.
    • (1984) Am J Physiol Endocrinol Metab , vol.247
    • Chubb, C.E.1    Desjardins, C.2
  • 7
    • 0015388725 scopus 로고
    • Kinetics of [3H]-testosterone metabolism in normal young men: Effects of medroxyprogesterone acetate (provera) administration
    • Clark AF, Calandra KS, and Bird CK. Kinetics of [3H]-testosterone metabolism in normal young men: effects of medroxyprogesterone acetate (provera) administration. J Steroid Biochem 3: 837-842, 1972.
    • (1972) J Steroid Biochem , vol.3 , pp. 837-842
    • Clark, A.F.1    Calandra, K.S.2    Bird, C.K.3
  • 8
    • 0019452776 scopus 로고
    • Autoregulation of testosterone secretion in perfused rat testes
    • Darney, KJ Jr and Ewing L. Autoregulation of testosterone secretion in perfused rat testes. Endocrinology 109: 993-995, 1981.
    • (1981) Endocrinology , vol.109 , pp. 993-995
    • Darney Jr., K.J.1    Ewing, L.2
  • 9
    • 0023188313 scopus 로고
    • Sustained inhibitory actions of a potent antagonist of gonadotropin-releasing hormone in postmenopausal women
    • Davis MR, Veldhuis JD, Rogol AD, Dufau ML, and Catt KJ. Sustained inhibitory actions of a potent antagonist of gonadotropin-releasing hormone in postmenopausal women. J Clin Endocrinol Metab 64: 1268-1274, 1987.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 1268-1274
    • Davis, M.R.1    Veldhuis, J.D.2    Rogol, A.D.3    Dufau, M.L.4    Catt, K.J.5
  • 10
    • 0009606688 scopus 로고
    • Secretion of testosterone in anesthetized dogs
    • Eik-Nes KB. Secretion of testosterone in anesthetized dogs. Endocrinology 71: 101-106, 1962.
    • (1962) Endocrinology , vol.71 , pp. 101-106
    • Eik-Nes, K.B.1
  • 12
    • 0030921610 scopus 로고    scopus 로고
    • Specific linkages among luteinizing hormone, follicle stimulating hormone, and testosterone release in the peripheral blood and human spermatic vein: Evidence for both positive (feed-forward) and negative (feedback) within-axis regulation
    • Foresta C, Bordon P, Rossato M, Mioni R, and Veldhuis JD. Specific linkages among luteinizing hormone, follicle stimulating hormone, and testosterone release in the peripheral blood and human spermatic vein: evidence for both positive (feed-forward) and negative (feedback) within-axis regulation. J Clin Endocrinol Metab 82: 3040-3046, 1997.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3040-3046
    • Foresta, C.1    Bordon, P.2    Rossato, M.3    Mioni, R.4    Veldhuis, J.D.5
  • 13
    • 0028194849 scopus 로고
    • The Brown Norway rat as a model of male reproductive aging: Evidence for both primary and secondary testicular failure
    • Gruenewald DA, Naai MA, Hess DL, and Matsumoto AM. The Brown Norway rat as a model of male reproductive aging: evidence for both primary and secondary testicular failure. J Gerontol R Psychol Sci Soc Sci 49: B42-B50, 1994.
    • (1994) J Gerontol R Psychol Sci Soc Sci , vol.49
    • Gruenewald, D.A.1    Naai, M.A.2    Hess, D.L.3    Matsumoto, A.M.4
  • 14
    • 0031736458 scopus 로고    scopus 로고
    • Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone?
    • Grzywacz FW, Chen H, Allegretti J, and Zirkin BR. Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone? J Androl 19: 625-630, 1998.
    • (1998) J Androl , vol.19 , pp. 625-630
    • Grzywacz, F.W.1    Chen, H.2    Allegretti, J.3    Zirkin, B.R.4
  • 15
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    • Harman SM, Metter FJ, Tobin JD, Pearson J, and Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 86: 724-731, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, F.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 16
    • 0018950079 scopus 로고
    • Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin
    • Harman SM and Tsitouras PD. Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 51: 35-40, 1980.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 35-40
    • Harman, S.M.1    Tsitouras, P.D.2
  • 17
    • 0000799546 scopus 로고
    • Testosterone production and metabolic clearance rules with volumes of distribution in normal adult men and women
    • Horton R, Shinsnko J, and Forsham PH. Testosterone production and metabolic clearance rules with volumes of distribution in normal adult men and women. Acta Endocrinol 48: 446-458, 1965.
    • (1965) Acta Endocrinol , vol.48 , pp. 446-458
    • Horton, R.1    Shinsnko, J.2    Forsham, P.H.3
  • 18
    • 0022541149 scopus 로고
    • Effects of aging on the in vitro release of gonadotropin-releasing hormone
    • Jarjour LT, Handelsman DJ, and Swerdloff RS. Effects of aging on the in vitro release of gonadotropin-releasing hormone. Endocrinology 119: 1113-1117, 1986.
    • (1986) Endocrinology , vol.119 , pp. 1113-1117
    • Jarjour, L.T.1    Handelsman, D.J.2    Swerdloff, R.S.3
  • 19
    • 0020731767 scopus 로고
    • Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat
    • Karpas AE, Bremner WJ, Clifton DK, Steiner RA, and Dorsa DM. Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat. Endocrinology 112: 788-791, 1983.
    • (1983) Endocrinology , vol.112 , pp. 788-791
    • Karpas, A.E.1    Bremner, W.J.2    Clifton, D.K.3    Steiner, R.A.4    Dorsa, D.M.5
  • 21
    • 0030759141 scopus 로고    scopus 로고
    • Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator
    • Keenan DM and Veldhuis JD. Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator. Am J Physiol Regul Integr Comp Physiol 273: R1182-R1192, 1997.
    • (1997) Am J Physiol Regul Integr Comp Physiol , vol.273
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 22
    • 0031876840 scopus 로고    scopus 로고
    • A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis
    • Keenan DM and Veldhuis JD. A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis. Am J Physiol Endocrinol Metab 275: E157-E176, 1998.
    • (1998) Am J Physiol Endocrinol Metab , vol.275
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 23
    • 0035665125 scopus 로고    scopus 로고
    • Disruption of the hypothalamic luteinizing-hormone pulsing mechanism in aging men
    • Keenan DM and Veldhuis JD. Disruption of the hypothalamic luteinizing-hormone pulsing mechanism in aging men. Am J Physiol Regul Integr Comp Physiol 281: R1917-R1924, 2001.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 24
    • 0034968016 scopus 로고    scopus 로고
    • Hypothesis testing of the aging male gonadal axis via a biomathematical construct
    • Keenan DM and Veldhuis JD. Hypothesis testing of the aging male gonadal axis via a biomathematical construct. Am J Physiol Regul Integr Comp Physiol 280: R1755-R1771, 2001.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.280
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 25
    • 0942298219 scopus 로고    scopus 로고
    • Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men
    • Keenan DM and Veldhuis JD. Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men. Am J Physiol Regul Integr Comp Physiol 286: R381-R389, 2004.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 26
    • 0026702302 scopus 로고
    • Abrogation by a potent GnRH antagonist of the estrogen/progesterone- stimulated surge-like release of LH and FSH in postmenopausal women
    • Kolp LA, Pavlou SN, Urban RJ, Rivier JC, Vale WW, and Veldhuis JD. Abrogation by a potent GnRH antagonist of the estrogen/progesterone-stimulated surge-like release of LH and FSH in postmenopausal women. J Clin Endocrinol Metab 75: 993-997, 1992.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 993-997
    • Kolp, L.A.1    Pavlou, S.N.2    Urban, R.J.3    Rivier, J.C.4    Vale, W.W.5    Veldhuis, J.D.6
  • 28
    • 0036828155 scopus 로고    scopus 로고
    • Anatomical and functional evidence for a neural hypothalamic-testicular pathway that is independent of the pituitary
    • Lee S, Miselis R, and Rivier C. Anatomical and functional evidence for a neural hypothalamic-testicular pathway that is independent of the pituitary. Endocrinology 143: 4447-4454, 2002.
    • (2002) Endocrinology , vol.143 , pp. 4447-4454
    • Lee, S.1    Miselis, R.2    Rivier, C.3
  • 29
    • 16544393215 scopus 로고    scopus 로고
    • The rationale, efficacy and safety of androgen therapy in older men: Future research and current practice recommendations
    • Liu PY, Swerdloff RS, and Veldhuis JD. The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations. J Clin Endocrinol Metab 89: 4789-4796, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4789-4796
    • Liu, P.Y.1    Swerdloff, R.S.2    Veldhuis, J.D.3
  • 30
    • 0015608662 scopus 로고
    • The effect of human chorionic gonadotropin on plasma steroid levels in young and old men
    • Longcope C. The effect of human chorionic gonadotropin on plasma steroid levels in young and old men. Steroids 21: 583-592, 1973.
    • (1973) Steroids , vol.21 , pp. 583-592
    • Longcope, C.1
  • 31
    • 0018763704 scopus 로고
    • Production of testosterone, 5 alpha-androstane-3 alpha, 17 beta-diol and androsterone by dispersed testicular interstitial cells and whole testes in vitro
    • Moger WH. Production of testosterone, 5 alpha-androstane-3 alpha, 17 beta-diol and androsterone by dispersed testicular interstitial cells and whole testes in vitro. J Endocrinol 80: 321-332, 1979.
    • (1979) J Endocrinol , vol.80 , pp. 321-332
    • Moger, W.H.1
  • 32
    • 0030744143 scopus 로고    scopus 로고
    • Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone
    • Morley JE, Kaiser F, Raum WJ, Perry 3rd HM, Flood JF, Jensen J, Silver AJ, and Roberts E. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA 94: 7537-7542, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7537-7542
    • Morley, J.E.1    Kaiser, F.2    Raum, W.J.3    Perry III, H.M.4    Flood, J.F.5    Jensen, J.6    Silver, A.J.7    Roberts, E.8
  • 33
    • 0028787967 scopus 로고
    • Amplified nocturnal luteinizing hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: Possible Leydig cell desensitization to endogenous LH signaling-a clinical research center study
    • Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, and Veldhuis JD. Amplified nocturnal luteinizing hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: possible Leydig cell desensitization to endogenous LH signaling-a clinical research center study. J Clin Endocrinol Metab 80: 3025-3031, 1995.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3025-3031
    • Mulligan, T.1    Iranmanesh, A.2    Gheorghiu, S.3    Godschalk, M.4    Veldhuis, J.D.5
  • 35
    • 0032879225 scopus 로고    scopus 로고
    • Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis
    • Mulligan T, Iranmanesh A, Kerzner R, Demers LW, and Veldhuis JD. Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis. Eur J Endocrinol 141: 257-266, 1999.
    • (1999) Eur J Endocrinol , vol.141 , pp. 257-266
    • Mulligan, T.1    Iranmanesh, A.2    Kerzner, R.3    Demers, L.W.4    Veldhuis, J.D.5
  • 36
    • 0035187808 scopus 로고    scopus 로고
    • Pulsatile iv infusion of recombinant human LH in leuprolide-suppressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male
    • Mulligan T, Iranmanesh A, and Veldhuis JD. Pulsatile iv infusion of recombinant human LH in leuprolide-suppressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male. J Clin Endocrinol Metab 86: 5547-5553, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5547-5553
    • Mulligan, T.1    Iranmanesh, A.2    Veldhuis, J.D.3
  • 37
    • 0019350631 scopus 로고
    • Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men
    • Muta K, Kato K, Akamine Y, and Ibayashi H. Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol 96: 154-162, 1981.
    • (1981) Acta Endocrinol , vol.96 , pp. 154-162
    • Muta, K.1    Kato, K.2    Akamine, Y.3    Ibayashi, H.4
  • 38
    • 84987592449 scopus 로고
    • The aging Leydig cell. III. Gonadotropin stimulation in men
    • Nankin HR, Lin T, and Murono EP. The aging Leydig cell. III. Gonadotropin stimulation in men. J Androl 2: 181-186, 1981.
    • (1981) J Androl , vol.2 , pp. 181-186
    • Nankin, H.R.1    Lin, T.2    Murono, E.P.3
  • 41
    • 0030450771 scopus 로고    scopus 로고
    • Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males
    • Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, and Veldhuis JD. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc Natl Acad Sci USA 93: 14100-14105, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14100-14105
    • Pincus, S.M.1    Mulligan, T.2    Iranmanesh, A.3    Gheorghiu, S.4    Godschalk, M.5    Veldhuis, J.D.6
  • 42
    • 0026463874 scopus 로고
    • Endocrine effects and pharmacokinetic characteristics of a potent new gonadotropin-releasing hormone antagonist (Ganirelix) with minimal histamine-releasing properties: Studies in postmenopausal women
    • Rabinovici J, Rothman P, Monroe SE, Nerenberg C, and Jaffe RB. Endocrine effects and pharmacokinetic characteristics of a potent new gonadotropin- releasing hormone antagonist (Ganirelix) with minimal histamine-releasing properties: studies in postmenopausal women. J Clin Endocrinol Metab 75: 1220-1225, 1992.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 1220-1225
    • Rabinovici, J.1    Rothman, P.2    Monroe, S.E.3    Nerenberg, C.4    Jaffe, R.B.5
  • 43
    • 0016236849 scopus 로고
    • Further studies on Leydig cell response to human choriogonadotropin
    • Reubens R, Dhondt M, and Vermeulen A. Further studies on Leydig cell response to human choriogonadotropin. J Clin Endocrinol Metab 39: 40-45, 1976.
    • (1976) J Clin Endocrinol Metab , vol.39 , pp. 40-45
    • Reubens, R.1    Dhondt, M.2    Vermeulen, A.3
  • 44
    • 0028130155 scopus 로고
    • Leydig cells: Endocrine, paracrine, and autocrine regulation
    • Saez JM. Leydig cells: endocrine, paracrine, and autocrine regulation. Endocr Rev 15: 574-626, 1994.
    • (1994) Endocr Rev , vol.15 , pp. 574-626
    • Saez, J.M.1
  • 45
    • 0016798380 scopus 로고
    • Effects of castration and gonadal steroids on serum luteinizing hormone and prolactin in old and young rats
    • Shaar CJ, Euker JS, Riegle GD, and Meites J. Effects of castration and gonadal steroids on serum luteinizing hormone and prolactin in old and young rats. J Endocrinol 66: 45-51, 1974.
    • (1974) J Endocrinol , vol.66 , pp. 45-51
    • Shaar, C.J.1    Euker, J.S.2    Riegle, G.D.3    Meites, J.4
  • 46
    • 0006171740 scopus 로고    scopus 로고
    • Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging
    • Sortino MA, Aleppo G, Scapagnini U, and Canonico PL. Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging. Brain Res Bull 41: 359-362, 1996.
    • (1996) Brain Res Bull , vol.41 , pp. 359-362
    • Sortino, M.A.1    Aleppo, G.2    Scapagnini, U.3    Canonico, P.L.4
  • 48
    • 0023550187 scopus 로고
    • The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: Response to clomiphene citrate
    • Tenover JS, Matsumoto AM, Plymate SR, and Bremner WJ. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab 65: 1118-1125, 1987.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 1118-1125
    • Tenover, J.S.1    Matsumoto, A.M.2    Plymate, S.R.3    Bremner, W.J.4
  • 49
    • 0023954666 scopus 로고
    • Contemporary aspects of discrete peak detection algorithms. 1. The paradigm of the luteinizing hormone pulse signal in men
    • Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML, and Veldhuis JD. Contemporary aspects of discrete peak detection algorithms. 1. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9: 3-37, 1988.
    • (1988) Endocr Rev , vol.9 , pp. 3-37
    • Urban, R.J.1    Evans, W.S.2    Rogol, A.D.3    Kaiser, D.L.4    Johnson, M.L.5    Veldhuis, J.D.6
  • 50
    • 0023448602 scopus 로고
    • The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations
    • Veldhuis JD, Cartoon ML, and Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686-7690, 1987.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7686-7690
    • Veldhuis, J.D.1    Cartoon, M.L.2    Johnson, M.L.3
  • 51
    • 0022551868 scopus 로고
    • Metabolic clearance of biologically active luteinizing hormone in man
    • Veldhuis JD, Fraioli F, Rogol AD, and Dufau ML. Metabolic clearance of biologically active luteinizing hormone in man. J Clin Invest 77: 1122-1128, 1986.
    • (1986) J Clin Invest , vol.77 , pp. 1122-1128
    • Veldhuis, J.D.1    Fraioli, F.2    Rogol, A.D.3    Dufau, M.L.4
  • 52
    • 4544352591 scopus 로고    scopus 로고
    • Pulsatile intravenous infusion of recombinant human luteinizing hormone under acute gonadotropin-releasing hormone receptor blockade reconstitutes testosterone secretion in young men
    • Veldhuis JD and Iranmanesh A. Pulsatile intravenous infusion of recombinant human luteinizing hormone under acute gonadotropin-releasing hormone receptor blockade reconstitutes testosterone secretion in young men. J Clin Endocrinol Metab 89: 4474-4479, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4474-4479
    • Veldhuis, J.D.1    Iranmanesh, A.2
  • 53
    • 0034457243 scopus 로고    scopus 로고
    • Older men manifest multifold synchrony disruption of reproductive neurohormone outflow
    • Veldhuis JD, Iranmanesh A, Godschalk M, and Mulligan T. Older men manifest multifold synchrony disruption of reproductive neurohormone outflow. J Clin Endocrinol Metab 85: 1477-1486, 2000.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1477-1486
    • Veldhuis, J.D.1    Iranmanesh, A.2    Godschalk, M.3    Mulligan, T.4
  • 55
    • 0033304566 scopus 로고    scopus 로고
    • Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men
    • Veldhuis JD, Iranmanesh A, Mulligan T, and Pincus SM. Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men. J Clin Endocrinol Metab 84: 3498-3505, 1999.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3498-3505
    • Veldhuis, J.D.1    Iranmanesh, A.2    Mulligan, T.3    Pincus, S.M.4
  • 56
    • 0022447036 scopus 로고
    • Cluster analysis: A simple, versatile and robust algorithm for endocrine pulse detection
    • Veldhuis JD and Johnson ML. Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. Am J Physiol Endocrinol Metab 250: E486-E493, 1986.
    • (1986) Am J Physiol Endocrinol Metab , vol.250
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 57
    • 77957099053 scopus 로고
    • Specific methodological approaches to selected contemporary issues in deconvolution analysis of pulsatile neuroendocrine data
    • Veldhuis JD and Johnson ML. Specific methodological approaches to selected contemporary issues in deconvolution analysis of pulsatile neuroendocrine data. Methods Neurosci 28: 25-92, 1995.
    • (1995) Methods Neurosci , vol.28 , pp. 25-92
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 58
    • 0024827270 scopus 로고
    • Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man
    • Veldhuis JD, Urban RJ, Beitins I, Blizzard RM, Johnson ML, and Dufau ML. Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man. J Steroid Biochem 33: 739-750, 1989.
    • (1989) J Steroid Biochem , vol.33 , pp. 739-750
    • Veldhuis, J.D.1    Urban, R.J.2    Beitins, I.3    Blizzard, R.M.4    Johnson, M.L.5    Dufau, M.L.6
  • 59
    • 0026762786 scopus 로고
    • Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men
    • Veldhuis JD, Urban RJ, Lizarralde G, Johnson ML, and Iranmanesh A. Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men. J Clin Endocrinol Metab 75: 52-58, 1992.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 52-58
    • Veldhuis, J.D.1    Urban, R.J.2    Lizarralde, G.3    Johnson, M.L.4    Iranmanesh, A.5
  • 60
    • 15444372939 scopus 로고    scopus 로고
    • Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men
    • Veldhuis JD, Veldhuis NJ, Keenan DM, and Iranmanesh A. Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men. Am J Physiol Endocrinol Metab 288: E775-E781, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Veldhuis, J.D.1    Veldhuis, N.J.2    Keenan, D.M.3    Iranmanesh, A.4
  • 61
    • 0035095288 scopus 로고    scopus 로고
    • Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men
    • Veldhuis JD, Zwart A, Mulligan T, and Iranmanesh A. Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men. J Clin Endocrinol Metab 86: 529-535, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 529-535
    • Veldhuis, J.D.1    Zwart, A.2    Mulligan, T.3    Iranmanesh, A.4
  • 62
    • 0024545519 scopus 로고
    • A new look at the andropause: Altered function of the gonadotrophs
    • Vermeulen A, Deslypere JP, and De Meirleir K. A new look at the andropause: altered function of the gonadotrophs. J Steroid Biochem 32: 163-165, 1989.
    • (1989) J Steroid Biochem , vol.32 , pp. 163-165
    • Vermeulen, A.1    Deslypere, J.P.2    De Meirleir, K.3
  • 63
    • 0018976513 scopus 로고
    • Comparison of androgen levels in ram rete testis fluid, testicular lymph and spermatic venous blood plasma: Evidence for a regulatory mechanism in the seminiferous tubules
    • Voglmayr JK, Roberson C, and Musto NA. Comparison of androgen levels in ram rete testis fluid, testicular lymph and spermatic venous blood plasma: evidence for a regulatory mechanism in the seminiferous tubules. Biol Reprod 23: 29-39, 1980.
    • (1980) Biol Reprod , vol.23 , pp. 29-39
    • Voglmayr, J.K.1    Roberson, C.2    Musto, N.A.3
  • 64
    • 0021713004 scopus 로고
    • The gonadotropin-suppressive activity of androgen is increased in elderly men
    • Winters SJ, Sherins RJ, and Troen P. The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism 33: 1052-1059, 1984.
    • (1984) Metabolism , vol.33 , pp. 1052-1059
    • Winters, S.J.1    Sherins, R.J.2    Troen, P.3
  • 65
    • 0020385669 scopus 로고
    • Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: Evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion
    • Winters SJ and Troen P. Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J Clin Endocrinol Metab 55: 560-565, 1982.
    • (1982) J Clin Endocrinol Metab , vol.55 , pp. 560-565
    • Winters, S.J.1    Troen, P.2
  • 66
    • 0344823859 scopus 로고    scopus 로고
    • The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis
    • Zhang FP, Pakarainen T, Poutanen M, Toppari J, and Huhtaniemi I. The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci USA 100: 13692-13697, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13692-13697
    • Zhang, F.P.1    Pakarainen, T.2    Poutanen, M.3    Toppari, J.4    Huhtaniemi, I.5
  • 67
    • 0029856760 scopus 로고    scopus 로고
    • Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and alpha-subunit release in young versus older men: Appraisal with high-specificity immunodiometric assay and deconvolution analysis
    • Zwart AD, Urban RJ, Odell WD, and Veldhuis JD. Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and alpha-subunit release in young versus older men: appraisal with high-specificity immunodiometric assay and deconvolution analysis. Eur J Endocrinol 135: 399-406, 1996.
    • (1996) Eur J Endocrinol , vol.135 , pp. 399-406
    • Zwart, A.D.1    Urban, R.J.2    Odell, W.D.3    Veldhuis, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.