Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 2, 2001, Pages 529-535

  Veldhuis, J D ^a   Zwart, A ^a   Mulligan, T ^b   Iranmanesh, A ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; GONADORELIN; KETOCONAZOLE; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; BIOAVAILABILITY; CLUSTER ANALYSIS; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; NEGATIVE FEEDBACK; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGING; ANDROGENS; ANDROSTENEDIONE; DEHYDROEPIANDROSTERONE; FEEDBACK; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; KETOCONAZOLE; LUTEINIZING HORMONE; MALE; MIDDLE AGED; PROLACTIN; RADIOIMMUNOASSAY; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TESTOSTERONE; THYROTROPIN; TIME FACTORS;

EID: 0035095288     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.2.529     Document Type: Article

References (53)

1. An examination of research design effects on the association of testosterone and male aging: Results of a meta-analysis
2. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men
3. Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamo-pituitary-gonadal axis
4. Attenuated release of biologically active luteinizing hormone in healthy aging men
5. Serum glycoprotein hormones and their free alpha-subunit in a healthy elderly population selected according to the SENIEUR protocol. Analyses with ultrasensitive time resolved fluoroimmunoassays
6. Age-related changes in the pituitary-testicular axis in normal men; Lower serum testosterone results from decreased bioactive LH drive
7. Influence of antiopioids on luteinizing hormone pulsatility in aging men
8. Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men
9. Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis
10. Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: Evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion
11. Amplified nocturnal luteinizing hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: Possible Leydig cell desensitization to endogenous LH signaling - A clinical research center study
12. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men
13. Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men
14. Differential responses of biologically active LH secretion in older versus young men to interruption of androgen negative feedback
15. Male hypothalamic-pituitary-gonadal axis
16. Neuroendocrine mechanisms by which selective Leydig-cell castration unleashes increased pulsatile LH release in the human: An experimental paradigm of short-term ketoconazole-induced hypoandrogenemia and deconvolution-estimated LH secretory enhancement
17. Disparate serum free testosterone concentrations and degrees of hypothalamo-pituitary-LH suppression are achieved by continuous versus pulsatile intravenous androgen replacement in men: A clinical experimental model of ketoconazole-induced reversible hypoandrogenemia with controlled testosterone add-back
18. Acute androgen receptor blockade increases luteinizing-hormone secretory activity in men
19. Deconvolution analysis of hormone data
20. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males
21. Role of endogenous aromatase in testosterone's short-term feedback regulation of 24-hour LH, FSH and GH release in young men
22. Evidence for attenuation of hypothalamic GnRH impulse strength with preservation of gonadotropin-releasing hormone (GnRH) pulse frequency in men with chronic renal failure
23. Evidence that androgen negativefeedback regulates hypothalamic GnRH impulse strength and the burst-like secretion of biologically active luteinizing hormone in men
24. Cluster analysis: A simple, versatile and robust algorithm for endocrine pulse detection
25. In vivo biological validation and biophysical modeling of the sensitivity and positive accuracy of endocrine peak detection: I. The LH pulse signal
26. Quantifying complexity and regularity of neurobiological systems
27. Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men
28. Amplitude modulation of a burst-like mode of cortisol secretion subserves the circadian giucocorticoid rhythm in man
29. Twenty-four hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts
30. Deconvolution analysis of neuroendocrine data: Waveform-specific and waveform-independent methods and applications
31. Serum LH and FSH responses to synthetic gonadotropin releasing hormone in normal men
32. Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone
33. Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and alpha-subunit release in young versus older men: Appraisal with high-specificity immunoradiometric assay and deconvolution analysis
34. On the role of gonadotropin-releasing hormone (GnRH) in the operation of the GnRH pulse generator in the Rhesus monkey
35. Operating behavior of dual or multiple endocrine pulse generators
36. Validation of deconvolution analysis of LH secretion and half-life
37. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes
38. Divergent effects of short-term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men
39. Evolution of deconvolution analysis as a hormone pulse detection method
40. Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: Estimating basal secretion and neurohormone half-life by deconvolution analysis
41. The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations
42. Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis
43. Explicating hypergonadotropism in postmenopausal women: A statistical model
44. Changes in the pituitarytesticular system with age
45. Orderliness of hormone release patterns: A complementary measure to conventional pulsatile and circadian analyses
46. Effects of age on the irregularity of LH and FSH serum concentrations in women and men
47. Pituitary hormone secretion in aging: Role of circadian rhythmicity and sleep
48. Impact of age on cortisol secretory dynamics basally and as driven by nutrient-withdrawal stress
49. The gonadotropin-suppressive activity of androgen is increased in elderly men
50. The aging Leydig cell III. Gonadotropin stimulation in men
51. Further studies on Leydig cell response to human choriogonadotropin
52. Pulsatile infusions of recombinant human LH in leuprolide-down-regulated older vs. young men unmask an impoverished Leydig-cell secretory response in aging to midphysiological LH stimuli
53. Aging alters feedforward and feedback linkages between LH and testosterone in healthy men