Formulation and characterization of immunoreactive tetanus toxoid biodegradable polymer particles

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 8, Issue 2, 2001, Pages 99-106

  Raghuvanshi, R S ^a   Singh, O ^a   Panda, A K ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Anti TT Antibody Titers; Controlled Release; Immunoreactivity; Polymer Panicles; Stability; Tetanus Toxoid

Indexed keywords

POLYGLACTIN; POLYLACTIDE; POLYMER; TETANUS TOXOID;

ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BIODEGRADATION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG FORMULATION; EMULSION; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROPHILICITY; HYDROPHOBICITY; IMMUNIZATION; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TETANUS;

ANIMALS; DRUG COMPOUNDING; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCIPIENTS; MALE; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYMERS; PROTEINS; RATS; RATS, WISTAR; TETANUS TOXOID;

EID: 0034988662     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/107175401750177089     Document Type: Article

References (40)

1. Biodegradable microspheres as controlled-release tetanus toxoid delivery systems
2. Albumin microspheres and microcapsule: Methodologies of manufacturing techniques
3. Enhanced immunogenicity of microencapsulated tetanus toxoid using stabilizing agents
4. Stabilization of tetanus toxoid in poly (DL lactic-co-glycolic acid) microspheres for the controlled release of antigen
5. Solvent evaporation processes for the production of con trolled release biodegradable microsphere formulations for therapeutics and vaccines
6. Single immunization vaccines: Controlled release technology to mimic repeated immunization
7. Multiple emulsion technology for the design of microspheres containing peptide and oligopeptides
8. Stability and release of bovine serum albumin encapsulated within poly (D,L-lactide-co-glycolide) microparticles
9. Time dependant polymerization of betalactoglobilin through disulfide bond at the water oil interface in emulsion
10. Biodegradable microsphere as vaccine delivery system
11. Parameters affecting the immunogenicity of microencapsulated tetanus toxoid
12. Long acting delivery system of interferon: IFN minipellet
13. Mechanism of polymer degradation and erosion
14. On protein denaturation in aqueous organic mixture but not in pure organic solvent
15. Chronic local tissue reaction, long term immunogenicity and immunogenic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microsphere composed of polylactide-co-glycolide polymers
16. New advances in microspheres based single dose vaccine
17. Controlled release of interleukin-2 from biodegradable microspheres
18. Improving stability and release kinetics of Microencapsulated tetanus toxoid by co-encapsulation of additives
19. Ambiguities in the preclinical quality assessment of microparticulate vaccines
20. Single shot with tetanus toxoid in biodegradable microsphere protects mice despite acid-induced denaturation of the antigen
21. The stability and immunogenicity of protein antigen encapsulated in biodegradable microparticles based on blend of lactide polymers and polyethylene glycol
22. Protein release from poly (lactic-co-glycolic acid) microspheres: Protein stability problems
23. Liquid liquid emulsification by rotor/stator homogenization
24. A single administration of tetanus toxoid in biodegradable microspheres elicit T cell and antibody responses similar or superior to those obtained with aluminum hydroxide
25. Practical aspects of polymerization of D,L-lactide initiated with tetraphenyltin
26. Polylactide microparticles prepared by double emulsion/evaporation technique-I. Effect of primary emulsion stability
27. Degradation of poly (D,L-lactic acid) microspheres: Effect of molecular weight
28. Why does PEG 400 co-encapsulated improve NGF stability and release from PLGA biodegradable microspheres
29. Improving protein therapeutics with sustained release formulation
30. Stabilization of dichloromethane induced protein denaturation during microencapsulation
31. Formulation strategy for the destabilization of tetanus toxoid in poly (lactide-co-glycolide) microsphere
32. Effect of the emulsion stability on the morphology and porosity of semicrystalline poly L-lactide microparticle prepared by w/o/w double emulsion-evaporation
33. Stabilization of tetanus and diphtheria toxoids against moisture induced aggregation
34. New strategies for the microencapsulation of tetanus vaccine
35. Immunogenicity and protection in small-animal models with controlled release tetanus toxoid microparticles as a single dose vaccine
36. A novel system based on a polaxomer/PLGA blend as tetanus toxoid delivery vehicle
37. Improved immunogenicity of a core coated tetanus toxoid delivery system
38. More about the degradation of LA/GA derived matrices in aqueous media
39. Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro
40. Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide)