메뉴 건너뛰기




Volumn 118, Issue 14, 2005, Pages 3153-3161

Mutational analysis of action of mitochondrial fusion factor mitofusin-2

Author keywords

Mitochondria; Mitochondrial membrane potential; Mitochondrial morphology; Mitofusin

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; MITOFUSIN 2; MUTANT PROTEIN; UNCLASSIFIED DRUG;

EID: 23844545553     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02449     Document Type: Article
Times cited : (46)

References (42)
  • 3
    • 0034682695 scopus 로고    scopus 로고
    • Mitochondria - The death signal integrators
    • Brenner, C. and Kroemer, G. (2000). Mitochondria - the death signal integrators. Science 289, 1150-1151.
    • (2000) Science , vol.289 , pp. 1150-1151
    • Brenner, C.1    Kroemer, G.2
  • 4
    • 2142758117 scopus 로고    scopus 로고
    • Mitochondrial dynamics in mammals
    • Chen, H. and Chan, D. C. (2004). Mitochondrial dynamics in mammals. Curr. Top. Dev. Biol. 59, 119-144.
    • (2004) Curr. Top. Dev. Biol. , vol.59 , pp. 119-144
    • Chen, H.1    Chan, D.C.2
  • 5
    • 0037455575 scopus 로고    scopus 로고
    • Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    • Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E. and Chan, D. C. (2003). Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160, 189-200.
    • (2003) J. Cell Biol. , vol.160 , pp. 189-200
    • Chen, H.1    Detmer, S.A.2    Ewald, A.J.3    Griffin, E.E.4    Fraser, S.E.5    Chan, D.C.6
  • 7
  • 8
    • 0142058391 scopus 로고    scopus 로고
    • Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion
    • Eura, Y., Ishihara, N., Yokota, S. and Mihara, K. (2003). Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J. Biochem. (Tokyo) 134, 333-344.
    • (2003) J. Biochem. (Tokyo) , vol.134 , pp. 333-344
    • Eura, Y.1    Ishihara, N.2    Yokota, S.3    Mihara, K.4
  • 9
    • 0035911154 scopus 로고    scopus 로고
    • Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion
    • Fritz, S., Rapaport, D., Klanner, E., Neupert, W. and Westermann, B. (2001). Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J. Cell Biol. 152, 683-692.
    • (2001) J. Cell Biol. , vol.152 , pp. 683-692
    • Fritz, S.1    Rapaport, D.2    Klanner, E.3    Neupert, W.4    Westermann, B.5
  • 10
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D. R. and Reed, J. C. (1998). Mitochondria and apoptosis. Science 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 11
    • 0034997256 scopus 로고    scopus 로고
    • The many shapes of mitochondrial membranes
    • Griparic, L. and van der Bliek, A. M. (2001). The many shapes of mitochondrial membranes. Traffic 2, 235-244.
    • (2001) Traffic , vol.2 , pp. 235-244
    • Griparic, L.1    van der Bliek, A.M.2
  • 12
    • 0031440879 scopus 로고    scopus 로고
    • Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase
    • Hales, K. G. and Fuller, M. T. (1997). Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell 90, 121-129.
    • (1997) Cell , vol.90 , pp. 121-129
    • Hales, K.G.1    Fuller, M.T.2
  • 14
    • 0242268107 scopus 로고    scopus 로고
    • Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis
    • Honda, S. and Hirose, S. (2003). Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. Biochem. Biophys. Res. Commun. 311, 424-432.
    • (2003) Biochem. Biophys. Res. Commun. , vol.311 , pp. 424-432
    • Honda, S.1    Hirose, S.2
  • 15
    • 0037459089 scopus 로고    scopus 로고
    • Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells
    • Ishihara, N., Jofuku, A., Eura, Y. and Mihara, K. (2003). Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells. Biochem. Biophys. Res. Commun. 301, 891-898.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 891-898
    • Ishihara, N.1    Jofuku, A.2    Eura, Y.3    Mihara, K.4
  • 16
    • 13444287961 scopus 로고    scopus 로고
    • Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity
    • Ishihara, N., Eura, Y. and Mihara, K. (2004). Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci. 117, 6535-6546.
    • (2004) J. Cell Sci. , vol.117 , pp. 6535-6546
    • Ishihara, N.1    Eura, Y.2    Mihara, K.3
  • 17
    • 0025914068 scopus 로고
    • A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction
    • Ito, W., Ishiguro, H. and Kurosawa, Y. (1991). A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction. Gene 102, 67-70.
    • (1991) Gene , vol.102 , pp. 67-70
    • Ito, W.1    Ishiguro, H.2    Kurosawa, Y.3
  • 18
    • 0141592470 scopus 로고    scopus 로고
    • hFis1, a novel component of the mammalian mitochondrial fission machinery
    • James, D. I., Parone, P. A., Mattenberger, Y. and Martinou, J. C. (2003). hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem. 278, 36373-36379.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36373-36379
    • James, D.I.1    Parone, P.A.2    Mattenberger, Y.3    Martinou, J.C.4
  • 19
  • 20
    • 0033231549 scopus 로고    scopus 로고
    • C. elegans dynamcn-related protein DRP-1 controls severing of the mitochondrial outer membrane
    • Labrousse, A. M., Zappaterra, M. D., Rube, D. A. and van der Bliek, A. M. (1999). C. elegans dynamcn-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell 4, 815-826.
    • (1999) Mol. Cell , vol.4 , pp. 815-826
    • Labrousse, A.M.1    Zappaterra, M.D.2    Rube, D.A.3    van der Bliek, A.M.4
  • 21
    • 0036906665 scopus 로고    scopus 로고
    • Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
    • Legros, F., Lombes, A., Frachon, P. and Rojo, M. (2002). Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol. Biol. Cell 13, 4343-4354.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 4343-4354
    • Legros, F.1    Lombes, A.2    Frachon, P.3    Rojo, M.4
  • 22
    • 0038024175 scopus 로고    scopus 로고
    • A fuzzy mitochondrial fusion apparatus comes into focus
    • Mozdy, A. D. and Shaw, J. M. (2003). A fuzzy mitochondrial fusion apparatus comes into focus. Nat. Rev. Mol. Cell. Biol. 4, 468-478.
    • (2003) Nat. Rev. Mol. Cell. Biol. , vol.4 , pp. 468-478
    • Mozdy, A.D.1    Shaw, J.M.2
  • 23
    • 0034676096 scopus 로고    scopus 로고
    • Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
    • Mozdy, A. D., McCaffery, J. M. and Shaw, J. M. (2000). Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151, 367-380.
    • (2000) J. Cell Biol. , vol.151 , pp. 367-380
    • Mozdy, A.D.1    McCaffery, J.M.2    Shaw, J.M.3
  • 24
    • 0033152496 scopus 로고    scopus 로고
    • Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein
    • Nemoto, Y. and De Camilli, P. (1999). Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein. EMBO J. 18, 2991-3006.
    • (1999) EMBO J. , vol.18 , pp. 2991-3006
    • Nemoto, Y.1    De Camilli, P.2
  • 25
    • 0345600249 scopus 로고    scopus 로고
    • The division of endosymbiotic organelles
    • Osteryoung, K. W. and Nunnari, J. (2003). The division of endosymbiotic organelles. Science 302, 1698-1704.
    • (2003) Science , vol.302 , pp. 1698-1704
    • Osteryoung, K.W.1    Nunnari, J.2
  • 26
    • 0032493625 scopus 로고    scopus 로고
    • Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae
    • Rapaport, D., Brunner, M., Neupert, W. and Westermann, B. (1998). Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J. Biol. Chem. 273, 20150-20155.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20150-20155
    • Rapaport, D.1    Brunner, M.2    Neupert, W.3    Westermann, B.4
  • 27
    • 0037089084 scopus 로고    scopus 로고
    • Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo
    • Rojo, M., Legros, F., Chateau, D. and Lombes, A. (2002). Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J. Cell Sci. 115, 1663-1674.
    • (2002) J. Cell Sci. , vol.115 , pp. 1663-1674
    • Rojo, M.1    Legros, F.2    Chateau, D.3    Lombes, A.4
  • 28
    • 0842302344 scopus 로고    scopus 로고
    • Mitochondrial morphology is dynamic and varied
    • Rube, D. A. and van der Bliek, A. M. (2004). Mitochondrial morphology is dynamic and varied. Mol. Cell. Biochem. 256-257, 331-339.
    • (2004) Mol. Cell. Biochem. , vol.256-257 , pp. 331-339
    • Rube, D.A.1    van der Bliek, A.M.2
  • 29
    • 0035057837 scopus 로고    scopus 로고
    • Control of mitochondrial morphology by a human mitofusin
    • Santel, A. and Fuller, M. T. (2001). Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114, 867-874.
    • (2001) J. Cell Sci. , vol.114 , pp. 867-874
    • Santel, A.1    Fuller, M.T.2
  • 30
    • 0038783254 scopus 로고    scopus 로고
    • Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells
    • Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R. J. and Fuller, M. T. (2003). Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J. Cell Sci. 116, 2763-2774.
    • (2003) J. Cell Sci. , vol.116 , pp. 2763-2774
    • Santel, A.1    Frank, S.2    Gaume, B.3    Herrler, M.4    Youle, R.J.5    Fuller, M.T.6
  • 31
    • 0033525924 scopus 로고    scopus 로고
    • Oxidative phosphorylation at the fin de siecle
    • Saraste, M. (1999). Oxidative phosphorylation at the fin de siecle. Science 283, 1488-1493.
    • (1999) Science , vol.283 , pp. 1488-1493
    • Saraste, M.1
  • 32
    • 0033571410 scopus 로고    scopus 로고
    • Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape
    • Sesaki, H. and Jensen, R. E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147, 699-706.
    • (1999) J. Cell Biol. , vol.147 , pp. 699-706
    • Sesaki, H.1    Jensen, R.E.2
  • 33
    • 0035911963 scopus 로고    scopus 로고
    • UGO1 encodes an outer membrane protein required for mitochondrial fusion
    • Sesaki, H. and Jensen, R. E. (2001). UGO1 encodes an outer membrane protein required for mitochondrial fusion. J. Cell Biol. 152, 1123-1134.
    • (2001) J. Cell Biol. , vol.152 , pp. 1123-1134
    • Sesaki, H.1    Jensen, R.E.2
  • 34
    • 0038376024 scopus 로고    scopus 로고
    • Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane
    • Sesaki, H., Southard, S. M., Yaffe, M. P. and Jensen, R. E. (2003). Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol. Biol. Cell 14, 2342-2356.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2342-2356
    • Sesaki, H.1    Southard, S.M.2    Yaffe, M.P.3    Jensen, R.E.4
  • 35
    • 0036536714 scopus 로고    scopus 로고
    • Mitochondrial dynamics and division in budding yeast
    • Shaw, J. M. and Nunnari, J. (2002). Mitochondrial dynamics and division in budding yeast. Trends Cell Biol. 12, 178-184.
    • (2002) Trends Cell Biol. , vol.12 , pp. 178-184
    • Shaw, J.M.1    Nunnari, J.2
  • 36
    • 0035166814 scopus 로고    scopus 로고
    • Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
    • Smirnova, E., Griparic, L., Shurland, D. L. and van der Bliek, A. M. (2001). Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell 12, 2245-2256.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2245-2256
    • Smirnova, E.1    Griparic, L.2    Shurland, D.L.3    van der Bliek, A.M.4
  • 37
    • 0036322806 scopus 로고    scopus 로고
    • The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission
    • Tieu, Q., Okreglak, V., Naylor, K. and Nunnari, J. (2002). The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. J. Cell Biol. 158, 445-452.
    • (2002) J. Cell Biol. , vol.158 , pp. 445-452
    • Tieu, Q.1    Okreglak, V.2    Naylor, K.3    Nunnari, J.4
  • 38
    • 0036308235 scopus 로고    scopus 로고
    • Merging mitochondria matters: Cellular role and molecular machinery of mitochondrial fusion
    • Westermann, B. (2002). Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion. EMBO Rep. 3, 527-531.
    • (2002) EMBO Rep. , vol.3 , pp. 527-531
    • Westermann, B.1
  • 39
    • 0042160077 scopus 로고    scopus 로고
    • Mitochondrial membrane fusion
    • Westermann, B. (2003). Mitochondrial membrane fusion. Biochim. Biophys. Acta 1641, 195-202.
    • (2003) Biochim. Biophys. Acta , vol.1641 , pp. 195-202
    • Westermann, B.1
  • 40
    • 0034676095 scopus 로고    scopus 로고
    • The dynamcn-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria
    • Wong, E. D., Wagner, J. A., Gorsich, S. W., McCaffery, J. M., Shaw, J. M. and Nunnari, J. (2000). The dynamcn-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151, 341-352.
    • (2000) J. Cell Biol. , vol.151 , pp. 341-352
    • Wong, E.D.1    Wagner, J.A.2    Gorsich, S.W.3    McCaffery, J.M.4    Shaw, J.M.5    Nunnari, J.6
  • 41
    • 0037415638 scopus 로고    scopus 로고
    • The intramitochondrial dynamcn-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion
    • Wong, E. D., Wagner, J. A., Scott, S. V., Okreglak, V., Holewinske, T. J., Cassidy-Stone, A. and Nunnari, J. (2003). The intramitochondrial dynamcn-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J. Cell Biol. 160, 303-311.
    • (2003) J. Cell Biol. , vol.160 , pp. 303-311
    • Wong, E.D.1    Wagner, J.A.2    Scott, S.V.3    Okreglak, V.4    Holewinske, T.J.5    Cassidy-Stone, A.6    Nunnari, J.7
  • 42
    • 0006391810 scopus 로고    scopus 로고
    • Dynamic mitochondria
    • Yaffe, M. P. (1999). Dynamic mitochondria. Nat. Cell Biol. 1, E149-E150.
    • (1999) Nat. Cell Biol. , vol.1
    • Yaffe, M.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.