Phthalate exposure during pregnancy and lower anogenital index in boys: Wider implications for the general population?

Environmental Health Perspectives

Volumn 113, Issue 8, 2005, Pages

  Sharpe, Richard M ^a  

^a MRC Reproductive Biology Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; PHTHALIC ACID; TESTOSTERONE;

CONCENTRATION (PARAMETERS); CRYPTORCHISM; DISEASE ASSOCIATION; EDITORIAL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ENVIRONMENTAL HEALTH; EVIDENCE BASED MEDICINE; FETUS; GERM CELL TUMOR; GONADAL DYSGENESIS; HORMONE DETERMINATION; HUMAN; HYPOSPADIAS; INFANT; LIFESTYLE; MALE; MALE GENITAL SYSTEM DISEASE; NEWBORN; NONHUMAN; OLIGOSPERMIA; PATHOGENESIS; PATHOPHYSIOLOGY; POPULATION RESEARCH; PRENATAL EXPOSURE; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; RAT; SEX DIFFERENTIATION; TESTIS CANCER; TESTOSTERONE SYNTHESIS;

EID: 23844541287     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.113-a504     Document Type: Editorial

References (19)

1. Barlow NJ, McIntyre BS, Fostar PMD. 2004. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to d(n-butyl) phthalate. Toxicol Pathol 32:19-90.
2. Ema M, Miyawaki E. 2001. Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. Reprod Toxicol 15:189-194.
3. Fisher JS, Macpherson S, Marchetti N, Sharpe RM. 2003. Human 'testicular dysgenesis syndrome': a possible model based on in-utero exposure of the rat to dibutyl phthalete. Hum Reprod 18:1383-1394.
4. Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DNA, Parks L. 2000. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat Toxicol Sci 58:350-365.
5. Jorgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, et al. 2002. East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod 17:2199-2208.
6. Koch HM, Rossbach B, Drexler H, Angerer J. 2003. Internal exposure of the general population to DEHP and other phthalates - determination of secondary and primary phthalate monoester metabolites in urine. Environ Res 93:111-185.
7. Mahood IK, McKinnell C, Fisher JS, Walker M, Hallmark N, Sharps RM. 2005. Abnormal Leydig cell aggregation in the fetal testis of rats exposed to di(n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology 146:613-623.
8. Mylchreest E, Cattley RC, Foster PMD. 1998. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-bstyl) phthalate: an anti-androgenic mechanism? Toxicol Sci 43:41-60.
9. Mylchrsest E, Wallace DG, Cattley AC, Foster PMD. 2000. Doss-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation. Toxicol Sci 55:143-151.
10. Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, et al. 2000. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 58:339-349.
11. Richiardi L, Bellocco A, Adami HO, Torrang A, Barlow L, Hakulinen T, et al. 2004. Testicular cancer incidence in eight northern European countries: secular and recent trends. Cancer Epidemiol Biomarkers Prey 13:2151-2166.
12. Salazar-Martinez E, Romano-Riquer P, Yanez-Marquez E, Longnecker MP, Hernandez-Avila M. 2004. Anogenital distance in human male and female newborns: a descriptive, conss-sectional study. Environ Health 3:8; doi: 10.1186/1476-069X-3-8 [Online 13 September 2004].
13. Sharpe AM, Skakkebaek NE. 2003. Male reproductive disorders and the role of endocrine disruption: advances in understanding and identification of areas for future research. Pure Appl Chem 75:2023-2038.
14. Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Ceudill SP, et al. 2004. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect 112:331-338.
15. Skakkebaek NE, Rajpert-De Meyts E, Main KM. 2001. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972-978.
16. Swan SH, Main KM. Liu F, Stewart SL, Krose RL, Calafat AM, et al. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 113:1056-1061.
17. Thompson CJ, Ross SM, Gaido KW. 2004. Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology 145:1227-1237.
18. Wilson VS, Lambright C, Furr J, Ostby J, Wood C, Held G. et al. 2004. Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. Toxicol Lett 146:207-215.
19. Zhang Y, Jiang X, Chen B. 2004. Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. Reprod Toxicol 18:669-676.