Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site

Journal of Endocrinology

Volumn 186, Issue 2, 2005, Pages 353-365

  Hay, Colin W ^a   Sinclair, Elaine M ^a   Bermano, Giovanna ^a   Durward, Elaine ^a   Tadayyon, Mohammad ^b,c   Docherty, Kevin ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1; INSULIN; LUCIFERASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; INSULIN RELEASE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RADIOIMMUNOASSAY; RAT; REPORTER GENE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSCRIPTION INITIATION SITE;

ANIMALS; CELL LINE, TUMOR; CYCLIC AMP; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INSULIN; INSULINOMA; PEPTIDE FRAGMENTS; PROMOTER REGIONS (GENETICS); PROTEIN PRECURSORS; RATS; RESPONSE ELEMENTS; TRANSCRIPTION INITIATION SITE; TRANSFECTION;

EID: 23844496075     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06205     Document Type: Article

References (40)

1. Asfari M, Janjic D, Meda P, Li G, Halban PA & Wollheim CB 1992 Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 167-178.
2. Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E & Goodman HM 1980 Sequence of the human insulin gene. Nature 284 26-32.
3. Boam DS, Clark AR, & Docherty K 1990 Positive and negative regulation of the human insulin gene by multiple trans-acting factors. Journal of Biological Chemistry 265 8285-8296.
4. Chepurny OG, Hussain MA & Holz GG 2002 Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serinc/threonine protein kinase inhibitor Ro 31-8220. Endocrinology 143 2303-2313.
5. Clark AR & Docherty K 1992 The insulin gene. In Insulin: Molecular Biology to Pathology, pp 37-63. Eds FM Ashcroft & SJ Ashcroft. Oxford: IRL Press.
6. Dignam JD, Lebovitz RM & Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Research 11 1475-1489.
7. Doyle ME & Egan JM 2001 Glucagon-like peptide-1. Recent Progress in Hormone Research 56 377-399.
8. Drucker DJ 2001 Minireview: the glucagon-like peptides. Endocrinology 142 521-527.
9. Drucker DJ, Philippe J, Mojsov S, Chick WL & Habener JF 1987 Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. PNAS 84 3434-3438.
10. Edvell A & Lindstrom P 1999 Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea +/-). Endocrinology 140 778-783.
11. Fehmann HC & Habener JF 1992 Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130 159-166.
12. German M, Ashcroft S, Docherty K, Edlund H, Edlund T, Goodison S, Imura H, Kennedy G, Madsen O & Melloul D 1995 The insulin gene promoter. A simplified nomenclature [letter]. Diabetes 44 1002-1004.
13. Habener JH 2001 Glucagonlike peptide-1 agonist stimulation of Beta cell growth and development. Current Opinion in Endocrinology and Diabetes 8 74-81.
14. Han XG & Tuch BE 2001 Cloning and characterization of porcine insulin gene. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 129 87-95.
15. Hedges BS & Kumar S 2003 Genomic clocks and evolutionary timescales. Trends in Genetics 19 200-206.
16. Holz GG, Kuhtreiber WM & Habener JF 1993 Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 361 362-365.
17. Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K & Seino Y 1999 The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. Journal of Biological Chemistry 274 21095-21103.
18. Inagaki N, Maekawa T, Sudo T, Ishii S, Seino Y & Imura H 1992 c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. PNAS 89 1045-1049.
19. Itier JM, Douhet P, Desbois P, Joshi RL, Dandoy-Dron F, Jami J & Bucchini D 1996 Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region. Differentiation 60 309-316.
20. Kemp DM & Habener JF 2001 Insulinotropic hormone glucagon-like peptide 1 (GLP-1) activation of insulin gene promoter inhibited by p38 mitogen-activated protein kinase. Endocrinology 142 1179-1187.
21. Kieffer TJ & Habener JF 1999 The glucagon-like peptides. Endocrine Reviews 20 876-913.
22. Knop FK, Vilsboll T, Larsen S, Madsbad S, Holst JJ & Krarup T 2003 No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis. Diabetes Care 26 2581-2587.
23. Komatsu R, Matsuyama T, Namba M, Watanabe N, Itoh H, Kono N & Tarui S 1989 Glucagonostatic and insulinotropic action of glucagonlike peptide I-(7-36)-amide. Diabetes 38 902-905.
24. Macfarlane WM, Cragg H, Docherty HM, Read ML, James RF, Aynsley-Green A & Docherty K 1997 Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis). FEBS Letters 413 304-308.
25. Melloul D, Marshak S & Cerasi E 2002 Regulation of insulin gene transcription. Diabetologia 45 309-326.
26. Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Orskov C, Ritzel R & Schmiegel WH 1997 Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. American Journal of Physiology - Endocrinology and Metabolism 273 E981-E988.
27. Philippe J & Missotten M 1990 Functional characterization of a cAMP-responsive element of the rat insulin I gene. Journal of Biological Chemistry 265 1465-1469.
28. Sander M, Griffen SC, Huang J & German MS 1998 A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets. PNAS 95 11572-11577.
29. Seino S, Steiner DF & Bell GI 1987 Sequence of a New World primate insulin having low, biological potency and immunoreactivity. PNAS 84 7423-7427.
30. Seino S, Bell GI & Li WH 1992 Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys. Molecular Biology and Evolution 9 193-203.
31. Skoglund G, Hussain MA & Holz GG 2000 Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element. Diabetes 49 1156-1164.
32. Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF & Egan JM 2000 Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49 741-748.
33. Thorens B 1992 Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. PNAS 89 8641-8645.
34. Tomonari A, Yoshimoto K, Tanaka M, Iwahana H, Miyazaki J & Itakura M 1996 GGAAAT motifs play a major role in transcriptional activity of the human insulin gene in a pancreatic islet beta-cell line MIN6. Diabetologia 39 1462-1468.
35. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J & Bloom SR 1996 A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69-72.
36. Vincent BJ, Myers JS, Ho HJ, Kilroy GE, Walker JA, Watkins WS, Jorde LB & Batzer MA 2003 Following the LINEs: an analysis of primate genomic variation at human-specific LINE-1 insertion sites. Molecular Biology and Evolution 20 1338-1348.
37. Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W & Nauck MA 1996 Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. Journal of Clinical Endocrinology and Metabolism 81 327-332.
38. Xu G, Stoffers DA, Habener JF & Bonner-Weir S 1999 Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48 2270-2276.
39. Zander M, Madsbad S, Madsen JL & Holst JJ 2002 Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359 824-830.
40. Zhou J, Wang X, Pineyro MA & Egan JM 1999 Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48 2358-2366.