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Volumn 60, Issue 5, 1996, Pages 309-316

Human insulin gene expression in transgenic mice: Mutational analysis of the regulatory region

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CHLORAMPHENICOL ACETYLTRANSFERASE; CIS ACTING ELEMENT; HUMAN INSULIN; RNA; THYMIDINE KINASE;

EID: 0029817886     PISSN: 03014681     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002580050161     Document Type: Article
Times cited : (6)

References (38)
  • 2
    • 0025829697 scopus 로고
    • Extinction of the human insulin gene expression in insulinoma x fibroblast somatic cell hybrids involves cis-acting DNA elements
    • Besnard C, Monthioux E, Lorès P, Jami J, Daegelen D (1991) Extinction of the human insulin gene expression in insulinoma x fibroblast somatic cell hybrids involves cis-acting DNA elements. J Cell Physiol 146:349-355
    • (1991) J Cell Physiol , vol.146 , pp. 349-355
    • Besnard, C.1    Monthioux, E.2    Lorès, P.3    Jami, J.4    Daegelen, D.5
  • 3
    • 0024454676 scopus 로고
    • A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer
    • Boam DSW, Docherty K (1989) A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer. Biochem J 264:233-239
    • (1989) Biochem J , vol.264 , pp. 233-239
    • Boam, D.S.W.1    Docherty, K.2
  • 4
    • 0025361461 scopus 로고
    • Positive and negative regulation of the human insulin gene by multiple transacting factors
    • Boam DSW, Clark AR, Docherty K (1990) Positive and negative regulation of the human insulin gene by multiple transacting factors. J Biol Chem 265:8285-8296
    • (1990) J Biol Chem , vol.265 , pp. 8285-8296
    • Boam, D.S.W.1    Clark, A.R.2    Docherty, K.3
  • 6
    • 0027253839 scopus 로고
    • Far upstream regions of class II MHC Ea are necessary for position-independent, copy-dependent expression of Ea transgene
    • Carson S, Wiles MV (1993) Far upstream regions of class II MHC Ea are necessary for position-independent, copy-dependent expression of Ea transgene. Nucleic Acids Res 21:2065-2072
    • (1993) Nucleic Acids Res , vol.21 , pp. 2065-2072
    • Carson, S.1    Wiles, M.V.2
  • 7
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin JM, Przybyla AE, McDonald RJ, Rutter WJ (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.E.2    McDonald, R.J.3    Rutter, W.J.4
  • 8
    • 0025893145 scopus 로고
    • Regulatory regions of rat insulin I gene necessary for expression in transgenic mice
    • Dandoy-Dron F, Monthioux E, Jami J, Bucchini D (1991) Regulatory regions of rat insulin I gene necessary for expression in transgenic mice. Nucleic Acids Res 19:4925-4930
    • (1991) Nucleic Acids Res , vol.19 , pp. 4925-4930
    • Dandoy-Dron, F.1    Monthioux, E.2    Jami, J.3    Bucchini, D.4
  • 9
    • 0029006437 scopus 로고
    • Tissue-specific expresion of the rat insulin 1 gene in vivo requires both the enhancer and promoter regions
    • Dandoy-Dron F, Itier J-M, Monthioux E, Bucchini D, Jami J (1995) Tissue-specific expresion of the rat insulin 1 gene in vivo requires both the enhancer and promoter regions. Differentiation 58:291-295
    • (1995) Differentiation , vol.58 , pp. 291-295
    • Dandoy-Dron, F.1    Itier, J.-M.2    Monthioux, E.3    Bucchini, D.4    Jami, J.5
  • 10
    • 0016832087 scopus 로고
    • Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas
    • Dubois MT (1975) Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci USA 72:1340-1343
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 1340-1343
    • Dubois, M.T.1
  • 11
    • 0022377642 scopus 로고
    • Cell-specific expression of the rat insulin gene: Evidence for role of two distinct 5′ flanking elements
    • Edlund T, Walker MD, Barr PJ, Rutter WJ (1985) Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science 230:912-916
    • (1985) Science , vol.230 , pp. 912-916
    • Edlund, T.1    Walker, M.D.2    Barr, P.J.3    Rutter, W.J.4
  • 13
    • 0026602931 scopus 로고
    • The insulin and islet amyloid polypepticle genes contain similar cell-specific promoter elements that hind identical β-cell nuclear complexes
    • German MS, Moss LG, Wang J, Rutter WJ (1992) The insulin and islet amyloid polypepticle genes contain similar cell-specific promoter elements that hind identical β-cell nuclear complexes. Mol Cell Biol 12:1777-1788
    • (1992) Mol Cell Biol , vol.12 , pp. 1777-1788
    • German, M.S.1    Moss, L.G.2    Wang, J.3    Rutter, W.J.4
  • 14
    • 0026471057 scopus 로고
    • Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
    • German MS, Wang J, Chadwick RB, Rutter WJ (1992) Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev 6:2165-2176
    • (1992) Genes Dev , vol.6 , pp. 2165-2176
    • German, M.S.1    Wang, J.2    Chadwick, R.B.3    Rutter, W.J.4
  • 15
    • 0024558096 scopus 로고
    • Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice
    • Greaves DR, Wilson FD, Lang G, Kioussis D (1989) Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 56:979-986
    • (1989) Cell , vol.56 , pp. 979-986
    • Greaves, D.R.1    Wilson, F.D.2    Lang, G.3    Kioussis, D.4
  • 16
    • 0023663887 scopus 로고
    • Position-independent, high-level expression of the human β-globin gene in transgenic mice
    • Grosveld F, Assendelft GB van, Greaves DR, Kollias C, (1987) Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975-985
    • (1987) Cell , vol.51 , pp. 975-985
    • Grosveld, F.1    Van Assendelft, G.B.2    Greaves, D.R.3    Kollias, C.4
  • 18
    • 0019423594 scopus 로고
    • Use of avidin-biotin-peroxidase (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures
    • Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 29:577-580
    • (1981) J Histochem Cytochem , vol.29 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 19
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 20
    • 0023477391 scopus 로고
    • A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer
    • Karlsson O, Edlund T, Moss JB, Rutter WJ, Walker MD (1987) A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci USA 84:8819-8823
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Moss, J.B.3    Rutter, W.J.4    Walker, M.D.5
  • 21
    • 0024494832 scopus 로고
    • Individual protein-binding domains of the insulin gene enhancer positively activate β-cell-specific transcription
    • Karlsson O, Walker MD, Rutter WJ, Edlund T (1989) Individual protein-binding domains of the insulin gene enhancer positively activate β-cell-specific transcription. Mol Cell Biol 9:823-827
    • (1989) Mol Cell Biol , vol.9 , pp. 823-827
    • Karlsson, O.1    Walker, M.D.2    Rutter, W.J.3    Edlund, T.4
  • 22
    • 0025280050 scopus 로고
    • Insulin gene enhancer binding protein Is1-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
    • Karlsson O, Thor S, Norberg T, Ohlsson H, Edlund T (1990) Insulin gene enhancer binding protein Is1-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344:879-882
    • (1990) Nature , vol.344 , pp. 879-882
    • Karlsson, O.1    Thor, S.2    Norberg, T.3    Ohlsson, H.4    Edlund, T.5
  • 23
    • 0026439947 scopus 로고
    • Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells
    • Kennedy GC, Rutter WJ (1992) Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells. Proc Natl Acad Sci USA 89:11498-11502
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11498-11502
    • Kennedy, G.C.1    Rutter, W.J.2
  • 25
    • 0021047474 scopus 로고
    • The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure
    • Madsen OD, Cohen RM, Fitch FW, Rubinstein AH, Steiner DF (1985) The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure. Fndocrinology 113:2135-2144
    • (1985) Fndocrinology , vol.113 , pp. 2135-2144
    • Madsen, O.D.1    Cohen, R.M.2    Fitch, F.W.3    Rubinstein, A.H.4    Steiner, D.F.5
  • 27
    • 0024025198 scopus 로고
    • Systematic binding analysis of the insulin gene transcription control region: Insulin and immunoglobulin enhancers utilize similar transactivators
    • Moss LG, Moss JB, Rutter WJ (1988) Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators. Mol Cell Biol 8:2620-2627
    • (1988) Mol Cell Biol , vol.8 , pp. 2620-2627
    • Moss, L.G.1    Moss, J.B.2    Rutter, W.J.3
  • 28
    • 0025292710 scopus 로고
    • Pan: A transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs
    • Nelson C, Shen LP, Meister A, Fodor F, Rutter WJ (1990) Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev 4:1035-1043
    • (1990) Genes Dev , vol.4 , pp. 1035-1043
    • Nelson, C.1    Shen, L.P.2    Meister, A.3    Fodor, F.4    Rutter, W.J.5
  • 29
    • 2642628564 scopus 로고
    • A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer
    • Ohlsson H, Karlsson K, Edlund T (1988) A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer. Proc Natl Acad Sci USA 85:4228-4231
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4228-4231
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 30
    • 0026386775 scopus 로고
    • Novel insulin promoter-and enhancer-binding proteins that discriminate between pancreatic α- and β-cells
    • Ohlsson H, Thor S, Edlund T (1991) Novel insulin promoter-and enhancer-binding proteins that discriminate between pancreatic α- and β-cells. Mol Endocrinol 5:897-904
    • (1991) Mol Endocrinol , vol.5 , pp. 897-904
    • Ohlsson, H.1    Thor, S.2    Edlund, T.3
  • 31
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259
    • (1993) EMBO J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 32
    • 0027944249 scopus 로고
    • Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
    • Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD (1994) Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci USA 91:10465-10469
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10465-10469
    • Petersen, H.V.1    Serup, P.2    Leonard, J.3    Michelsen, B.K.4    Madsen, O.D.5
  • 33
    • 0027371952 scopus 로고
    • The helix-loop-helix transcription factor USF (upsteam stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer
    • Read ML, Clark AR, Docherty K (1993) The helix-loop-helix transcription factor USF (upsteam stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer. Biochem J 295:233-237
    • (1993) Biochem J , vol.295 , pp. 233-237
    • Read, M.L.1    Clark, A.R.2    Docherty, K.3
  • 37
    • 0345116028 scopus 로고
    • Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1
    • Wagner MJ, Sharp AJ, Summer WC (1981) Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1. Proc Natl Acad Sci USA 78:1441-1445
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 1441-1445
    • Wagner, M.J.1    Sharp, A.J.2    Summer, W.C.3
  • 38
    • 0021071029 scopus 로고
    • Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes
    • Walker MD, Edlund T, Boulet AM, Rutter WJ (1983) Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature 306:557-561
    • (1983) Nature , vol.306 , pp. 557-561
    • Walker, M.D.1    Edlund, T.2    Boulet, A.M.3    Rutter, W.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.