-
2
-
-
0034762203
-
The Raf/MEK/ERK pathway: New concepts of activation
-
Peyssonnaux C, Eychene A. The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell. 2001;93:53-62.
-
(2001)
Biol Cell
, vol.93
, pp. 53-62
-
-
Peyssonnaux, C.1
Eychene, A.2
-
4
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
5
-
-
0346752519
-
BRAF mutations in non-Hodgkin's lymphoma
-
Lee JW, Yoo NJ, Soung YH, et al. BRAF mutations in non-Hodgkin's lymphoma. Br J Cancer. 2003;89:1958-1960.
-
(2003)
Br J Cancer
, vol.89
, pp. 1958-1960
-
-
Lee, J.W.1
Yoo, N.J.2
Soung, Y.H.3
-
6
-
-
0242574321
-
BRAF and KRAS mutations in stomach cancer
-
Lee SH, Lee JW, Soung YH, et al. BRAF and KRAS mutations in stomach cancer. Oncogene. 2003;22:6942-6945.
-
(2003)
Oncogene
, vol.22
, pp. 6942-6945
-
-
Lee, S.H.1
Lee, J.W.2
Soung, Y.H.3
-
7
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
Brose MS, Volpe P, Feldman M, et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res. 2002;62:6997-7000.
-
(2002)
Cancer Res
, vol.62
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
-
8
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116:855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
-
9
-
-
0032146118
-
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability
-
Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res. 1998;58:3455-3460.
-
(1998)
Cancer Res
, vol.58
, pp. 3455-3460
-
-
Cunningham, J.M.1
Christensen, E.R.2
Tester, D.J.3
-
10
-
-
0027742295
-
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
-
Fishel R, Lescoe MK, Rao MR, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 1993;75:1027-1038.
-
(1993)
Cell
, vol.75
, pp. 1027-1038
-
-
Fishel, R.1
Lescoe, M.K.2
Rao, M.R.3
-
11
-
-
0028221943
-
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
-
Bronner CE, Baker SM, Morrison PT, et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature. 1994; 368:258-261.
-
(1994)
Nature
, vol.368
, pp. 258-261
-
-
Bronner, C.E.1
Baker, S.M.2
Morrison, P.T.3
-
12
-
-
0030803659
-
Strand-specific mismatch repair in mammalian cells
-
Modrich P. Strand-specific mismatch repair in mammalian cells. J Biol Chem. 1997;272:24727-24730.
-
(1997)
J Biol Chem
, vol.272
, pp. 24727-24730
-
-
Modrich, P.1
-
13
-
-
7444228694
-
BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
-
Trojan J, Brieger A, Raedle J, Weber N, Kriener S, Kronenberger B et al. BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability. Int J Colorectal Dis. 2004;19:538-544.
-
(2004)
Int J Colorectal Dis
, vol.19
, pp. 538-544
-
-
Trojan, J.1
Brieger, A.2
Raedle, J.3
Weber, N.4
Kriener, S.5
Kronenberger, B.6
-
14
-
-
0033984095
-
Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis
-
Guanti G, Resta N, Simone C, et al. Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. Hum Mol Genet. 2000;9:283-287.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 283-287
-
-
Guanti, G.1
Resta, N.2
Simone, C.3
-
15
-
-
0035965935
-
PTEN gene mutations in colorectal cancers displaying microsatellite instability
-
Shin KH, Park YJ, Park JG. PTEN gene mutations in colorectal cancers displaying microsatellite instability. Cancer Lett. 2001;174:189-194.
-
(2001)
Cancer Lett
, vol.174
, pp. 189-194
-
-
Shin, K.H.1
Park, Y.J.2
Park, J.G.3
-
16
-
-
0032849832
-
Hereditary nonpolyposis colorectal cancer (HNPCC)
-
Lynch HT. Hereditary nonpolyposis colorectal cancer (HNPCC). Cytogenet Cell Genet. 1999;86:130-135.
-
(1999)
Cytogenet Cell Genet
, vol.86
, pp. 130-135
-
-
Lynch, H.T.1
-
17
-
-
0029089259
-
Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
-
Marra G, Boland CR. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst. 1995;87:1114-1125.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 1114-1125
-
-
Marra, G.1
Boland, C.R.2
-
18
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VH. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. 2002;418:934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.H.6
-
19
-
-
0035899946
-
Bethesda guidelines: Relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer
-
Raedle J, Trojan J, Brieger A, et al. Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer. Ann Intern Med. 2001;135:566-576.
-
(2001)
Ann Intern Med
, vol.135
, pp. 566-576
-
-
Raedle, J.1
Trojan, J.2
Brieger, A.3
-
20
-
-
0029843950
-
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
-
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996; 93:9821-9826.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
21
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA. 1998;95: 6870-6875.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6870-6875
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
-
22
-
-
0035117962
-
Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer
-
Grady WM, Rajput A, Lutterbaugh JD, Markowitz SD. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res. 2001;61:900-902.
-
(2001)
Cancer Res
, vol.61
, pp. 900-902
-
-
Grady, W.M.1
Rajput, A.2
Lutterbaugh, J.D.3
Markowitz, S.D.4
-
23
-
-
0036143918
-
Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system
-
Trojan J, Zeuzem S, Randolph A, et al. Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology. 2002;122:211-219.
-
(2002)
Gastroenterology
, vol.122
, pp. 211-219
-
-
Trojan, J.1
Zeuzem, S.2
Randolph, A.3
-
24
-
-
9144271690
-
Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation
-
Domingo E, Espin E, Armengol M, et al. Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. Genes Chromosomes Cancer. 2004;39:138-142.
-
(2004)
Genes Chromosomes Cancer
, vol.39
, pp. 138-142
-
-
Domingo, E.1
Espin, E.2
Armengol, M.3
-
25
-
-
0037065954
-
Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
-
Deng G, Peng E, Gum J, Terdiman J, Sleisenger M, Kim YS. Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer. Br J Cancer. 2002;86:574-579.
-
(2002)
Br J Cancer
, vol.86
, pp. 574-579
-
-
Deng, G.1
Peng, E.2
Gum, J.3
Terdiman, J.4
Sleisenger, M.5
Kim, Y.S.6
-
26
-
-
0033135049
-
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
-
Deng G, Chen A, Hong J, Chae HS, Kim YS. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res. 1999;59:2029-2033.
-
(1999)
Cancer Res
, vol.59
, pp. 2029-2033
-
-
Deng, G.1
Chen, A.2
Hong, J.3
Chae, H.S.4
Kim, Y.S.5
-
27
-
-
1542713412
-
BRAF gene is not mutated in mismatch repair-proficient or -deficient plasma cell dyscrasias
-
Velangi M, Matheson E, Taylor P, Jackson G, Hall AG, Irving JA. BRAF gene is not mutated in mismatch repair-proficient or -deficient plasma cell dyscrasias. Leukemia. 2004;18:658-659.
-
(2004)
Leukemia
, vol.18
, pp. 658-659
-
-
Velangi, M.1
Matheson, E.2
Taylor, P.3
Jackson, G.4
Hall, A.G.5
Irving, J.A.6
-
28
-
-
0141593677
-
BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair
-
Wang L, Cunningham JM, Winters JL, et al. BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res. 2003;63:5209-5212.
-
(2003)
Cancer Res
, vol.63
, pp. 5209-5212
-
-
Wang, L.1
Cunningham, J.M.2
Winters, J.L.3
-
29
-
-
0036224279
-
Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
-
Jass JR, Walsh MD, Barker M, Simms LA, Young J, Leggett BA. Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability. Eur J Cancer. 2002;38:858-866.
-
(2002)
Eur J Cancer
, vol.38
, pp. 858-866
-
-
Jass, J.R.1
Walsh, M.D.2
Barker, M.3
Simms, L.A.4
Young, J.5
Leggett, B.A.6
-
30
-
-
0034495161
-
Genetic and epigenetic modification of MLH1
-
Perucho M. Genetic and epigenetic modification of MLH1. Am J Pathol. 2000;157:1052-1053.
-
(2000)
Am J Pathol
, vol.157
, pp. 1052-1053
-
-
Perucho, M.1
-
31
-
-
0033847512
-
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
-
Kuismanen SA, Holmberg MT, Salovaara R, de la Chapelle A, Peltomaki P. Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. Am J Pathol. 2000;156:1773-1779.
-
(2000)
Am J Pathol
, vol.156
, pp. 1773-1779
-
-
Kuismanen, S.A.1
Holmberg, M.T.2
Salovaara, R.3
De La Chapelle, A.4
Peltomaki, P.5
-
32
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane MF, Loda M, Gaida GM, et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 1997;57:808-811.
-
(1997)
Cancer Res
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
Loda, M.2
Gaida, G.M.3
-
33
-
-
13144307115
-
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
-
Veigl ML, Kasturi L, Olechnowicz J, et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci USA. 1998;95:8698-8702.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8698-8702
-
-
Veigl, M.L.1
Kasturi, L.2
Olechnowicz, J.3
-
34
-
-
0037468517
-
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
-
Sieber OM, Lipton L, Crabtree M, et al. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med. 2003;348:791-799.
-
(2003)
N Engl J Med
, vol.348
, pp. 791-799
-
-
Sieber, O.M.1
Lipton, L.2
Crabtree, M.3
-
35
-
-
0038501052
-
Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH
-
Sampson JK, Dolwani S, Jones S, et al. Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. Lancet. 2003;362:39-41.
-
(2003)
Lancet
, vol.362
, pp. 39-41
-
-
Sampson, J.K.1
Dolwani, S.2
Jones, S.3
-
36
-
-
0034681117
-
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
-
Toyota M, Ohe-Toyota M, Ahuja N, Issa JP. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA. 2000;97: 710-715.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 710-715
-
-
Toyota, M.1
Ohe-Toyota, M.2
Ahuja, N.3
Issa, J.P.4
-
37
-
-
0032739329
-
CpG island methylator phenotypes in aging and cancer
-
Toyota M, Issa JP. CpG island methylator phenotypes in aging and cancer. Semin Cancer Biol. 1999;9:349-357.
-
(1999)
Semin Cancer Biol
, vol.9
, pp. 349-357
-
-
Toyota, M.1
Issa, J.P.2
-
38
-
-
0033587747
-
CpG island methylator phenotype in colorectal cancer
-
Toyota M, Ahuja N, Ohe-Toyota M, Herman IG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 1999;96:8681-8686.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8681-8686
-
-
Toyota, M.1
Ahuja, N.2
Ohe-Toyota, M.3
Herman, I.G.4
Baylin, S.B.5
Issa, J.P.6
-
39
-
-
0034015438
-
CpG-island methylation in aging and cancer
-
Issa IP. CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol. 2000;249:101-118.
-
(2000)
Curr Top Microbiol Immunol
, vol.249
, pp. 101-118
-
-
Issa, I.P.1
-
40
-
-
1642535480
-
BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
-
Deng G, Bell I, Crawley S, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res. 2004;10:191-195.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 191-195
-
-
Deng, G.1
Bell, I.2
Crawley, S.3
-
41
-
-
2942514668
-
Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer
-
Miyaki M, Iijima T, Yamaguchi T, Kadofuku T, Funata N, Mori T. Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer. Cancer Lett. 2004;211:105-109.
-
(2004)
Cancer Lett
, vol.211
, pp. 105-109
-
-
Miyaki, M.1
Iijima, T.2
Yamaguchi, T.3
Kadofuku, T.4
Funata, N.5
Mori, T.6
-
42
-
-
10744233937
-
Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
-
Umar A, Boland CK, Terdiman JP, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004;96:261-268.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 261-268
-
-
Umar, A.1
Boland, C.K.2
Terdiman, J.P.3
-
43
-
-
2342504508
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
-
Goel A, Arnold CN, Niedzwiecki D, et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004;64:3014-3021.
-
(2004)
Cancer Res
, vol.64
, pp. 3014-3021
-
-
Goel, A.1
Arnold, C.N.2
Niedzwiecki, D.3
|