Evidence for unfolding and refolding of gas-phase cytochrome c ions in a Paul trap

Journal of the American Society for Mass Spectrometry

Volumn 16, Issue 9, 2005, Pages 1493-1497

  Badman, Ethan R ^a,b   Myung, Sunnie ^a   Clemmer, David E ^a  

^a INDIANA UNIVERSITY   (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C IONS; FOLDED STRUCTURES; GAS PHASE; ION TRAPPING;

ARRAYS; CONFORMATIONS; ELECTRON TRAPS; IONIZATION; TRANSITION METALS;

IONS;

CYTOCHROME C; ION;

ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; CONFORMATION; ELECTROSPRAY; GAS; ION TRAP MASS SPECTROMETRY; PROTEIN FOLDING; STRUCTURE ANALYSIS;

CYTOCHROMES C; GASES; KINETICS; PHASE TRANSITION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN RENATURATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 23844442205     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2005.04.013     Document Type: Article

References (24)

1. Y.W. Bai, T.R. Sosnick, L. Mayne, S.W. Englander Protein Folding Intermediates Native-State Hydrogen Exchange Science 269 1995 192 197
2. C.M. Dobson, A. Sali, M. Karplus Protein Folding A Perspective From Theory and Experiment Angew. Chem. Int. Ed. Engl. 37 1998 868 893
3. M. Gruebele The Fast Protein Folding Problem Annu. Rev. Phys. Chem. 50 1999 485 516
4. K.B. Shelimov, D.E. Clemmer, R.R. Hudgins, M.F. Jarrold Protein Structure in Vacuo The Gas Phase Conformations of BPTI and Cytochrome c J. Am. Chem. Soc. 119 1997 2240 2248
5. T. Wyttenbach, G.V. Helden, M.T. Bowers Gas-Phase. Conformation of Biological Molecules Bradykinin J. Am. Chem. Soc. 118 1996 8355 8364
6. S.J. Valentine, D.E. Clemmer H/D Exchange Levels of Shape-Resolved Cytochrome c Conformers in the Gas Phase J. Am. Chem. Soc. 119 1997 3558 3566
7. B.E. Winger, K.J. Lightwahl, A.L. Rockwood, R.D. Smith Probing Qualitative Conformation Differences of Multiply Protonated Gas-Phase Proteins via Hydrogen/Deuterium Isotopic Exchange With Water-d2 J. Am. Chem. Soc. 114 1992 5897 5898
8. T.D. Wood, R.A. Chorush, F.M. Wampler, D.P. Little, P.B. Oconnor, F.W. McLafferty Gas-Phase Folding and Unfolding of Cytochrome c Cations Proc. Natl. Acad. Sci. U.S.A. 92 1995 2451 2454
9. F.W. McLafferty, Z.Q. Guan, U. Haupts, T.D. Wood, N.L. Kelleher Gaseous Conformational Structures of Cytochrome c. J. Am. Chem. Soc. 120 1998 4732 4740
10. M.A. Freitas, C.L. Hendrickson, M.R. Emmett, A.G. Marshall Gas-Phase Bovine Ubiquitin Cation Conformations Resolved by Gas-Phase Hydrogen/Deuterium Exchange Rate and Extent Int. J. Mass Spectrom. 187 1999 565 575
11. D.M. Horn, K. Breuker, A.J. Frank, F.W. McLafferty Kinetic Intermediates in the Folding of Gaseous Protein Ions Characterized by Electron Capture Dissociation Mass Spectrometry J. Am. Chem. Soc. 123 2001 9792 9799
12. K. Breuker, H.B. Oh, D.M. Horn, B.A. Cerda, F.W. McLafferty Detailed Unfolding and Folding of Gaseous Ubiquitin Ions Characterized by Electron Capture Dissociation J. Am. Chem. Soc. 124 2002 6407 6420
13. R.A. Zubarev, D.M. Horn, E.K. Fridriksson, N.L. Kelleher, N.A. Kruger, M.A. Lewis, B.K. Carpenter, F.W. McLafferty Electron Capture Dissociation for Structural Characterization of Multiply Charged Protein Cations Anal. Chem. 72 2000 563 573
14. J. Woenckhaus, Y. Mao, M.F. Jarrold Hydration of Gas Phase Proteins Folded +5 and Unfolded +7 Charge States of Cytochrome c. J. Phys. Chem. B 101 1997 847 851
15. M.F. Jarrold Peptides and Proteins in the Vapor Phase Annu. Rev. Phys. Chem. 51 2000 179 207
16. J. Woenckhaus Drift Time Mass Spectrometric Protein Hydration Experiments Int. J. Mass Spectrom. 213 2002 9 24
17. E.R. Badman, C.S. Hoaglund-Hyzer, D.E. Clemmer Monitoring Structural Changes of Proteins in an Ion Trap over ∼10-200 ms Unfolding Transitions in Cytochrome c Ions Anal. Chem. 73 2001 6000 6007
18. S. Myung, E.R. Badman, Y.J. Lee, D.E. Clemmer Structural Transitions of Electrosprayed Ubiquitin Ions Stored in an Ion Trap over ∼10 ms to 30 s J. Phys. Chem. A. 106 2002 9976 9982
19. C.S. Hoaglund-Hyzer, J.W. Li, D.E. Clemmer Mobility Labeling for Parallel CID of Ion Mixtures Anal. Chem. 72 2000 2737 2740
20. D.E. Clemmer, M.F. Jarrold Ion Mobility Measurements and Their Applications to Clusters and Biomolecules J. Mass Spectrom. 32 1997 577 592
21. S.J. Valentine, J.G. Anderson, A.D. Ellington, D.E. Clemmer Disulfide-Intact and -Reduced Lysozyme in the Gas Phase Conformations and Pathways of Folding and Unfolding J. Phys. Chem. B 101 1997 3891 3900
22. S.A. McLuckey, J.M. Wells, J.L. Stephenson, D.E. Goeringer Novel Quadrupole Ion Trap Methods for Characterizing the Chemistry of Gaseous Macro-Ions Int. J. Mass Spectrom. 200 2000 137 161
23. E.R. Badman, S. Myung, D.E. Clemmer Gas-Phase Separations of Protein and Peptide Ion Fragments Generated by Collision-Induced Dissociation in an Ion Trap Anal. Chem. 74 2002 4889 4894
24. A.A. Shvartsburg, M.F. Jarrold An Exact Hard-Spheres Scattering Model for the Mobilities of Polyatomic Ions Chem. Phys. Lett. 261 1996 86 91