Biological consequences of petite mutations in Candida glabrata

Journal of Antimicrobial Chemotherapy

Volumn 56, Issue 2, 2005, Pages 307-314

  Brun, Sophie ^a   Dalle, Frédéric ^b   Saulnier, Patrick ^c   Renier, Gilles ^a   Bonnin, Alain ^b   Chabasse, Dominique ^a   Bouchara, Jean Philippe ^a  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b HÔPITAL DU BOCAGE   (France)

^c INSERM   (France)

Author keywords

Adherence; Cell surface hydrophobicity; Petite mutants; Virulence

Indexed keywords

CARBOHYDRATE; CONCANAVALIN A; EPA1 PROTEIN; ETHIDIUM BROMIDE; FLUCONAZOLE; FUNGAL PROTEIN; GLUCOSE; LECTIN; MANNOSE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA GLABRATA; CANDIDIASIS; CARBOHYDRATE ANALYSIS; CELL ADHESION; CELL STRAIN CACO 2; CELL SURFACE; CELL WALL; CONTROLLED STUDY; DRUG EXPOSURE; ELECTROPHORETIC MOBILITY; EXPERIMENTAL INFECTION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; FUNGAL CELL; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS ISOLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MICROELECTROPHORESIS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHASE PARTITIONING; PHYSICAL PARAMETERS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURFACE PROPERTY; WILD TYPE;

ANIMALS; BACTERIAL ADHESION; BRAIN; CACO-2 CELLS; CANDIDA GLABRATA; CANDIDIASIS; CELL WALL; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; FLOW CYTOMETRY; FUNGAL PROTEINS; HUMANS; KIDNEY; LECTINS; LIVER; MICE; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRULENCE;

EID: 23844438716     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dki200     Document Type: Article

References (35)

1. Pfaller MA, Diekema DJ, Jones RN et al. Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Program Surveillance, 1997 to 2000. J Clin Microbiol 2002; 40: 852-6.
2. Morschhauser J. The genetic basis of fluconazole resistance development in Candida albicans. Biochim Biophys Acta 2002; 1587: 240-8.
3. Sanglard D, Odds FC. Resistance of Candida species to antifungal agents: Molecular mechanisms and clinical consequences. Lancet Infect Dis 2002; 2: 73-85.
4. Miyazaki H, Miyazaki Y, Geber A et al. Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata. Antimicrob Agents Chemother 1998; 42: 1695-701.
5. Brun S, Bergès T, Poupard P et al. Mechanisms of azole resistance in petite mutants of Candida glabrata. Antimicrob Agents Chemother 2004; 48: 1788-96.
6. Sanglard D, Ischer F, Bille J. Role of the ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata. Antimicrob Agents Chemother 2001; 45: 1174-83.
7. Chen XJ, Clark-Walker GD. The petite mutation in yeasts: 50 years on. Int Rev Cytol 2000; 194: 197-238.
8. Defontaine A, Bouchara JP, Declerk P et al. In vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata. J Med Microbiol 1999; 48: 663-70.
9. Brun S, Aubry C, Lima O et al. Relationships between respiration and susceptibility to azole antifungals in Candida glabrata. Antimicrob Agents Chemother 2003; 47: 847-53.
10. Bouchara JP, Zouhair R, Le Boudouil S et al. In vivo selection of an azole-resistant petite mutant of Candida glabrata. J Med Microbiol 2000; 49: 977-84.
11. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
12. Rosenberg M, Gutnick DL, Rosenberg E. Adherence of bacteria to hydrocarbon: A simple method for measuring cell surface hydrophobicity. FEMS Microbiol Lett 1980; 9: 29-33.
13. Busscher HJ, Weerkamp AH. Specific and non-specific interactions in bacterial adhesion to solid substrata. FEMS Microbiol Rev 1987; 46: 165-73.
14. Cormack BP, Ghori N, Falkow S. An adhesion of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 1999; 285: 578-82.
15. Dalle F, Jouault T, Trinel PA et al. β-1,2- and α-1,2-linked oligomannosides mediate adherence of Candida albicans blastospores to human enterocytes in vitro. Infect Immun 2003; 71: 7061-8.
16. Hopwood V, Poulain D, Fortier B et al. A monoclonal antibody to a cell wall component of Candida albicans. Infect Immun 1986; 54: 222-7.
17. Traven A, Wong JMS, Xu D et al. Interorganellar communication: altered nuclear gene expression profiles in a yeast mitochondrial mutant. J Biol Chem 2001; 276: 4020-7.
18. De Las Penas A, Pan SJ, Castano I et al. Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR:-dependent transcriptional silencing. Genes Dev 2003; 17: 2245-58.
19. Calcagno AM, Bignell E, Warn P et al. Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol 2003; 50: 1309-18.
20. Calcagno AM, Bignell E, RogersTR et al. Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence. Yeast 2004; 21: 557-68.
21. Hazen KC, Lay JG, Hazen BW et al. Partial biochemical characterization of cell surface hydrophobicity and hydrophilicity of Candida albicans. Infect Immun 1990; 58: 3469-76.
22. Mazuoka J, Hazen KC. Cell wall protein mannosylation determines Candida albicans cell surface hydrophobicity. Microbiology 1997; 143:-dependent: 3015-21.
23. Wilkie D, Evans I. Mitochondria and the yeast cell surface: Implications for carcinogenesis. Trends Biochem Sci 1982; 7: 147-51.
24. Ferreira T, Regnacq M, Alimardani P et al. Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion. Biochem J 2004; 378: 899-908.
25. Glee PM, Sundstrom P, Hazen KC. Expression of surface hydrophobic proteins by Candida albicans in vivo. Infect Immun 1995; 63: 1373-9.
26. Hazen KC. Participation of yeast cell surface hydrophobicity in adherence of Candida albicans to human epithelial cells. Infect Immun 1989; 57: 1894-900.
27. Luo G, Samaranayake LP. Candida glabrata, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicans. APMIS 2002; 110: 601-10.
28. Bagnat M, Keranen S, Shevchenko A et al. Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci USA 2000; 97: 3254-9.
29. Arendrup M, Horn T, Frimodt-Moller N. In vivo pathogenicity of eight medically relevant Candida species in an animal model. Infection 2002; 30: 286-91.
30. Brieland J, Essig D, Jackson G et al. Comparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice. Infect Immun 2001; 69: 5046-55.
31. Aoki S, Ito-Kuwa S, Nakamura Y et al. Comparative pathogenicity of wild-type strain and respiratory mutants of Candida albicans in mice. Zentralbl Bakteriol 1990; 273: 332-43.
32. Roth-Ben Arie Z, Altboum Z, Shadkchan Y et al. Loss and regain of virulence of a Candida albicans mutant as assessed in systemic murine candidiasis. J Mycol Med 2001; 11: 117-22.
33. Weger SD, Ganji A, Clemons KV et al. Correlation of the frequency of petite formation by isolates of Saccharomyces cerevisiae with virulence. Med Mycol 2002; 40: 161-8.
34. Roth-Ben Arie Z, Altboum Z, Sandovsky-Losica H et al. Adhesion of Candida albicans mutant strains to host tissue. FEMS Microbiol Lett 1998; 163: 121-7.
35. Tinkelenberg AH, Liu Y, Alcantara F et al. Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem 2000; 275: 40667-70.