Comparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice

Infection and Immunity

Volumn 69, Issue 8, 2001, Pages 5046-5055

  Brieland, J ^a   Essig, D ^a   Jackson, C ^a   Frank, D ^a   Loebenberg, D ^a   Menzel, F ^a   Arnold, B ^a   DiDomenico, B ^a   Hare, R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDIASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IMMUNOPATHOGENESIS; INFECTION SENSITIVITY; INFLAMMATION; KIDNEY INFECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CANDIDA; CANDIDA ALBICANS; CANDIDIASIS; IMMUNOCOMPETENCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; KIDNEY; MALE; MICE; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE;

EID: 0034911695     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.8.5046-5055.2001     Document Type: Article

References (86)

1. Production and function of cytokines in natural and acquired immunity to Candida albicans infections
2. Comparison of fluconazole, amphotericin B, and flucytosine in treatment of a murine model of disseminated infection with Candida glabrata in immunocompromised mice
3. A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts
4. Genetic characterization of a phospholipase C gene from Candida albicans: Presence of homologous sequences in Candida species other than Candida albicans
5. Heterogeneous secretory responses of phagocytes from different anatomical districts to the dimorphic fungus Candida albicans
6. Recombinant and natural gamma-interferon activation of macrophages in vitro: Different dose requirements for induction of killing against phagocytizable and nonphagocytizable fungi
7. In vitro and in vivo activities of SCH56592 (Posaconazole), a new triazole antifungal agent, against Aspergillus and Candida
8. Evidence for a correlation between proteinase secretion and vulvovaginal candidosis
9. T cell subsets and IFN-γ production in resistance to systemic candidiasis in immunized mice
10. Two types of mouse helper T cell clones. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
11. Pathogenesis. I. Interactions of host cells and fungi
12. Antifungal type I responses are upregulated in IL-10-deficient mice
13. Interactions of phagocytic cells with Candida and other opportunistic fungi
14. Incidence of polyene-resistant yeasts recovered from clinical specimens
15. Role of tumor necrosis factor and colony-stimulating factors in phagocyte function against Candida albicans
16. Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: Activation by interferon γ and tumor necrosis factor
17. Tumor necrosis factor and Candida albicans
18. Regulation of human polymorphonuclear neutrophil (PMN) activity against Candida albicans by large granular lymphocytes via release of a PMN-activating factor
19. Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8. 1990
20. Introduction to Candida
21. Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: Increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release
22. Candida glabrata: Review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
23. Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells
24. Chronic vulvovaginal candidiasis: Characteristics of women with Candida albicans, Candida glabrata and no Candida
25. A novel method for real time quantitative RT-PCR
26. Regulation of chemokine gene expression in human peripheral blood neutrophils phagocytosing microbial pathogens
27. Yeasts of medical importance
28. In vitro study of contact mediated killing of Candida albicans hyphae by activated murine peritoneal macrophages in a serum-free medium
29. Real time quantitative PCR
30. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation
31. Fluconazole resistance in Candida glabrata
32. Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: Importance of T-cell-independent regulation of resistance to T. gondii
33. Evidence implicating phospholipase as a virulence factor of Candida albicans
34. Stimulation of neutrophils by tumor necrosis factor
35. Dynamics of Candida isolates from humans from 1992-1995 in Greifswald, Germany
36. Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: Frequency, characteristics and evaluation of factors influencing outcome
37. Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities
38. Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis
39. Cytokines, phagocytes and pentoxifylline
40. Characterization of tumor necrosis factor-deficient mice
41. Histochemical and immunochemical study of the fate of Candida albicans inside human neutrophil phagolysosomes
42. Priming of the human neutrophil respiratory burst by granulocyte-macrophage colony stimulating factor and tumor necrosis factor-alpha involves regulation at a post-cell surface receptor level: Enhancement of the effect of agents which directly activate G proteins
43. Human neutrophils produce high levels of the interleukin 1 receptor antagonist in response to granulocyte/macrophage colony stimulating factor and tumor necrosis factor alpha
44. Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-alpha double deficient mice infected with Candida albicans
45. + T helper responses in mice with low-level Candida albicans infection
46. Defective antifungal T-helper 1 (Th1) immunity in a murine model of allogeneic T-cell-depleted bone marrow transplantation and its restoration by treatment with cytokine antagonists
47. Comparison of IFN-γ, GCSF, and GMCSF for priming leukocyte-mediated hyphal damage of opportunistic fungal pathogens
48. Activation of murine polymorphonuclear neutrophils for fungicidal activity by recombinant gamma interferon
49. Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection
50. Interleukin 12, interferon gamma, and tumor necrosis factor-alpha are the key cytokines of the generalized Shwartzman reaction
51. Nosocomial candidiasis: Emerging species, reservoirs, and modes
52. Cure of murine candidiasis by recombinant soluble interleukin 4 receptor
53. A Th1-Th2 like switch in candidiasis: New perspectives for therapy
54. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis
55. Gamma interferon is not essential in host defense against disseminated candidiasis in mice
56. Suppressive effects of interleukin 10 on human mononuclear phagocyte functions against Candida albicans and Staphylococcus aureus
57. Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils
58. Interleukin-4 suppresses antifungal activity of human mononuclear phagocytes against Candida albicans in association with decreased uptake of blastoconidia
59. Mechanism and resistance to fungal infections
60. Biological role of helper T-cell subsets in candidiasis
61. Immunity to Candida albicans Th1, Th2 cells and beyond
62. + subset expression in murine candidiasis
63. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis
64. Innate and adaptive immunity in Candida albicans infections and saprophytism
65. An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis
66. Neutralization of IL-10 upregulates nitric oxide production and protects susceptible mice from challenge with Candida albicans
67. The secreted aspartate proteinase of Candida albicans: Physiology of secretion and virulence of a proteinase-deficient mutant
68. Molecular typing and fluconazole susceptibility of urinary Candida glabrata isolates from hospitalized patients
69. Activation of human polymorphonuclear neutrophil functions by interferon gamma and tumor necrosis factors
70. Cachectin/tumor necrosis factor exerts endocrine, paracrine and autocrine control of inflammatory responses
71. Candida (Torulopsis) glabrata
72. Pathogenesis and epidemiology of vulvovaginal candidiasis
73. Critical role of germ tube formation in the pathogenesis of candidal vaginitis
74. High-frequency switching in Candida albicans
75. TNF receptors in murine Candida albicans infection: Evidence for an important role of TNF receptor p55 in antifungal defense
76. Yeasts of human origin
77. Increased resistance to systemic candidiasis in athymic or interleukin-10-depleted mice
78. Characterization of an azole-resistant Candida glabrata isolate
79. Early resistance of interleukin 10 knockout mice to acute systemic candidiasis
80. Macrophages and resistance to candidiasis
81. Fluconazole resistance in AIDS patients
82. Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients
83. Importance of Candida species other than C. albicans as pathogens in oncology patients
84. Candida albicans and Candida krusei differentially induce human blood mononuclear cell interleukin-12 and gamma interferon production
85. In vitro effects of interleukin 10, prednisolone, and GM-CSF on the non-specific immune function of human polymorphonuclear leukocytes and monocytes