Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 2, 2003, Pages 765-775

  Visser, S A G ^a,d   Huntjens, D R H ^a   Van Der Graaf, P H ^b   Peletier, L A ^c   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; MIDAZOLAM;

ADAPTATION; ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOLUS INJECTION; COMPARTMENT MODEL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; ELECTROENCEPHALOGRAM; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE;

EID: 0142241270     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.054510     Document Type: Article

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