Distribution of antihistamines into the CSF following intranasal delivery

Biopharmaceutics and Drug Disposition

Volumn 18, Issue 4, 1997, Pages 335-346

  Chou, Kang Jye ^a   Donovan, Maureen D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

antihistamines; blood brain barrier; CSF; intra arterial administration; nasal administration; plasma

Indexed keywords

ANTIHISTAMINIC AGENT; CHLORCYCLIZINE; CHLORPHENIRAMINE; HYDROXYZINE; TRIPROLIDINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CEREBROSPINAL FLUID; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAARTERIAL DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; CHLORPHENIRAMINE; HISTAMINE H1 ANTAGONISTS; HYDROXYZINE; INJECTIONS, INTRA-ARTERIAL; MALE; NASAL CAVITY; PIPERAZINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TRIPROLIDINE;

EID: 0030991550     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199705)18:4<335::AID-BDD22>3.0.CO;2-W     Document Type: Article

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