Expression of natural antimicrobial peptide β-defensin-2 and Langerhans cell accumulation in epidermis from human non-healing leg ulcers

Folia Histochemica et Cytobiologica

Volumn 43, Issue 3, 2005, Pages 133-136

  Galkowska, Hanna ^a   Olszewski, Waldemar L ^a,b   Wojewodzka, Urszula ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b Central Clinical Hospital   (Poland)

Author keywords

Innate immunity; Langerhans cells; Leg ulcers; defensin 2

Indexed keywords

BETA DEFENSIN 2; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; VASCULOTROPIN;

ADULT; ARTICLE; BACTERIAL COLONIZATION; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC FOOT; DISEASE CLASSIFICATION; DISEASE SEVERITY; FOOT ULCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LANGERHANS CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION; SKIN BIOPSY; SKIN ULCER; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 23744449562     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ali RS, Falconer A, Ikram M, Bissett CE, Cerio R, Quinn AG (2001) Expression of the peptide antibiotics human β defensin 1 and human β defensin-2 in normal human skin. J Invest Dermatol 117: 106-111
2. Butmarc J, Yufit T, Carson P, Falanga V (2004) Human β defensin-2 expression is increased in chronic wounds. Wound Rep Reg 12: 439-443
3. Dinolus JGH, Mentele L, Fredericks LP, Dale BA, Darmstadt GL (2003) Keratinocyte expression of human β defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diag Lab Immunol 10: 161-166
4. Durr M, Peschel A (2002) Chemokines meet defensins: the merging concept of chemoattractants and antimicrobial peptides in host defense. Inflamm Immunol 70: 6515-6517
5. Erdag G, Morgan JR (2002) Interleukin-1 and interleukin-6 enhance the antimicrobial properties of cultured composite keratinocyte grafts. Ann Surg 235: 113-124
6. Fulton C, Anderson GM, Zasloff M, Bull R, Quinn AG (1997) Expression of natural peptide antibiotics in human skin. Lancet 350: 1750-1751
7. Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S, Carbone D (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92: 4150-4166
8. Gallo RL, Murakami M, Ohtake T, Zaiou M (2002) Biology and clinical relevance of naturally occurring antimicrobial peptides. J Allergy Clin Immunol 110: 823-831
9. Harder J, Bartels J, Christophers E, Schroeder JM (1997) A peptide antibiotic from human skin. Nature 387: 861-863
10. Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T (2002) Human β defensin-2 production in keratinocytes is regulated by interleukin 1, bacteria, and the state of differentiation. J Invest Dermatol 118: 275-281
11. Miller G, Pillarisetty VG, Shah AB, Lahrs S, Xing Z, DeMatteo RP (2002) Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function. J Immunol 169: 2875-2885
12. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA, Pestonjamasp V, Piralno J, Huttner K, Gallo RL (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414: 454-457
13. Sorensen OE, Cowland JB, Theilgaard-Monch K, Liu L, Ganz T, Borregaard N (2003) Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol 170: 5583-5589
14. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroeder JM, Wang JM, Howard OMZ, Oppenheim JJ (1999) β defensins: linking innate and adoptive immunity through dendritic and T cell CCR6. Science 286: 525-528
15. Yang D, Chertov O, Oppenheim JJ (2001) Participation of mammalian defensins and cathelicidins in antimicrobial immunity: receptors and activities of human defensins and cathelicidin (LL-37). J Leukoc Biol 69: 691-697