Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function

Journal of Immunology

Volumn 169, Issue 6, 2002, Pages 2875-2885

  Miller, George ^a   Pillarisetty, Venu G ^a   Shah, Alaap B ^a   Lahrs, Svenja ^a   Xing, Zhou ^a   DeMatteo, Ronald P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CD11 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVITY; CELL COUNT; CELL POPULATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLYSIS; DENDRITIC CELL; DNA VECTOR; GENE FUNCTION; GENE OVEREXPRESSION; GENE TRANSFER; IMMUNOPHARMACOLOGY; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VIVO STUDY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; VIRAL GENE DELIVERY SYSTEM;

EID: 0037105385     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.6.2875     Document Type: Article

References (53)

1. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch
2. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse
3. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified
4. Developmental pathways of dendritic cells in vivo: Distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice
5. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs
6. Heterogeneity of mouse spleen dendritic cells: In vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover
7. + lymphoid dendritic cells
8. + and CD8a
9. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology
10. + subclasses of dendritic cells undergo phenotypic and functional maturation in vitro and in vivo
11. IL-12 induction by a Th1-inducing adjuvant in vivo: Dendritic cell subsets and regulation by IL-10
12. high murine dendritic cells in vivo: A comparative analysis with Flt3 ligand
13. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
14. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production
15. Dendritic cells in the T-cell areas of lymphoid organs
16. Development of CD8α-positive dendritic cells from a common myeloid progenitor
17. - dendritic cell subset by a maturation process involving CD8a, DEC-205, and CD24 up-regulation
18. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
19. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a
20. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
21. Effects of excess GM-CSF levels on hematopoiesis and leukemia development in GMCSF/max 41 double transgenic mice
22. Dramatic numerical increase of functionally mature dendritic cells in FLT3 ligand-treated mice
23. + T cell responses by dysregulating antigen-presenting cell maturation
24. GM-CSF-induced in vivo expansion of splenic dendritic cells and their strong costimulation activity
25. Granulocyte/macrophage-colony-stimulating factor released by adenovirally transduced CT26 cells leads to the local expression of macrophage inflammatory protein 1α and accumulation of dendritic cells at vaccination sites in vivo
26. Long-lasting adenovirus transgene expression in mice through neonatal intrathymic tolerance induction without the use of immunosuppression
27. Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung
28. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
29. Thymic lymphomas mediate non-MHC-restricted, TNF-dependent lysis of the murine sarcoma WEHI-164
30. 257-264 determinant
31. Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion
32. Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
33. The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes
34. Local and systemic effects after adenoviral transfer of the murine granulocyte-macrophage colony-stimulating factor gene into mice
35. The development, maturation, and turnover rate of mouse spleen dendritic cell populations
36. Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice
37. Enhanced dendritic cell maturation by TNF-α or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic antitumor immune responses in vivo
38. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage
39. - dendritic cells regulate T cell responses
40. Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-α in psoriasis
41. Early molecular events in the induction phase of contact sensitivity
42. Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures
43. Interleukin-6 and tumour necrosis factor α are expressed by keratinocytes but not by Langerhans cells
44. Activated Langerhans cells release tumor necrosis factor
45. Detection of IL-1β, TNF-α, and IL-6 gene transcription by the polymerase chain reaction in keratinocytes, Langerhans cells and peritoneal exudate cells during infection with herpes simplex virus-1
46. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: Evidence for a soluble CD14-dependent pathway
47. The plasticity of dendritic cell responses to pathogens and their components
48. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
49. + dendritic cells expressing indoleamine 2,3-dioxygenase
50. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
51. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
52. + dendritic cells prolong the survival of vascularized heart allografts
53. In vivo manipulation of dendritic cells to induce therapeutic immunity