TT-232. Somatostatin sst1/sst4 receptor agonist, treatment of neuropathic pain, treatment of inflammation

Drugs of the Future

Volumn 30, Issue 6, 2005, Pages 558-566

  Helyes, Z ^a   Pinter E ^a   Szolcsanyi J ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BACLOFEN; CAPSAICIN; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLLYSYLCYSTEINYLTHREONINAMIDE 2,6 DISULFIDE; DICLOFENAC; GENISTEIN; MELOXICAM; MORPHINE; OCTREOTIDE; PARACETAMOL; PERTUSSIS TOXIN; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 4; VAPREOTIDE;

ALLODYNIA; ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; APOPTOSIS; ARTICLE; BINDING AFFINITY; CHRONIC ARTHRITIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENDOCRINE FUNCTION; HALF LIFE TIME; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MONONEUROPATHY; NERVE ENDING; NEUROPATHIC PAIN; NONHUMAN; PAW EDEMA; POLYNEUROPATHY; SENSORY NERVE; SOMATOSTATIN RELEASE; TUMOR CELL;

EID: 23744446101     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2005.030.06.911225     Document Type: Article

References (64)

1. Kéri, G., Mezö, I., Horváth, A., Vadász, Z., Teplán, I., Balogh, A., Csuka, O., Bökönyi, G., Szöke, B., Horváth, J., Idei, M., Seprödi, J. (Biosignal Kutato-Fejleszto Kft.). Octapeptide orheptapeptide derivatives, a process for preparing them as well as medicaments containing these compounds and the use of them. EP 0505680, JP 1993163299, US 5480870.
2. Braum, G., Lifferth, A., Birr, C. (Orpegen Pharma). Method for producing biostatin (TT-232 triacetate) and the analogs thereof. WO 2000011031, WO 2000011032, EP 1104439, JP 2002523425.
3. Szolcsányi, J., Helyes, Z., Oroszi, G., Németh, J., Pintér, E. Release of somatostatin and its role in the mediation of the anti-inflammatory effect induced by antidromic stimulation of sensory fibres of rat sciatic nerve. Br J Pharmacol 1998, 123: 936-42.
4. Szolcsányi, J., Pintér, E., Helyes, Z., Oroszi, G., Németh, J. Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors. Br J Pharmacol 1998, 125: 916-22.
5. Helyes, Z., Thán, M., Oroszi, G., Pintér, E., Németh, J., Kéri, Gy., Szolcsányi, J. Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat. Neurosci Lett 2000, 278: 185-8.
6. Helyes, Z., Szabó, Á., Németh, J., Jakab, B., Pintér, E., Bánvölgyi, Á., Kereskai, L., Kéri, Gy., Szolcsányi, J. Anti-inflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in Freund's adjuvant-induced chronic arthritis model of the rat. Arthritis Rheum 2004, 50: 1677-85.
7. Patel, Y.C., Greenwood, M.T., Panetta, L., Demchyshyn, L., Niznik, H., Srikant, C.B. Minireview: The somatostatin receptor family. Life Sci 1995, 57: 1249-65.
8. ten Bokum, A.M.C., Hofland, L.J., van Hagen, P.M. Somatostatin and somatostatin receptors in the immune system: A review. Eur Cytokine Netw 2000, 11: 161-76.
9. Gamse, R., Leeman, S.E., Holzer, P., Lembeck, F. Differential effects of capsaicin on the content of somatostain, substance P and neurotensin in the nervous system of the rat. Naunyn-Schmied Arch Pharmacol 1981, 7: 140-8.
10. Holzer, P. Peptidergic sensory neurones in the control of vascular function: Mechanisms and significance in the cutaneous and splanchnic vascular beds. Rev Physiol Biochem Pharmacol 1992, 121: 49-146.
11. Szolcsányi, J. Neurogenic inflammation: Reevaluation of axon reflex theory. In: Neurogenic Inflammation. P. Geppetti and P. Holzer (Eds.), CRC Press, Boca Raton, 1996, 35-44.
12. Lawson, S.N. Peptides and cutaneous polymodal nociceptor neurones. Progr Brain Res 1996, 113: 369-85.
13. Pintér, E., Helyes, Z., Németh, J., Szolcsányi, J. Somatostatin as anti-inflammatory neuromediator: In vivo and in vitro evidences. In: Neurogenic Inflammation, Neuroimmune Biology, Vol. V., A. Fischer and G. Jancsó (Eds.), Elsevier Science, The Netherlands 2005, in press.
14. Hoyer, D., Bell, G.I., Berelowitz, M. et al. Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 1995, 16: 86-8.
15. Wang, H., Bogen, C., Reisine, T., Dichter, M. SRIF-14 and SRIF-28 induce opposite effects on potassium currents in rat neocortical neurons. Proc Natl Acad Sci USA 1989, 86: 9616-20.
16. Buscail, L., Delesque, N., Esteve, J.P. et al. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by SRIF analogues: Mediation by human SRIF receptor subtypes SSTR1 and SSTR2. Proc Natl Acad Sci USA 1994, 91: 2315-9.
17. Reisine, T., Bell, G.I. Molecular properties of somatostatin receptors. Neuroscience 1995, 67: 777-90.
18. Hofland, L.J., Visser-Wisselaar, H.A., Lamberts, S.W.J. Somatostatin analogs: Clinical application in relation to human somatostatin receptor subtypes. Biochem Pharmacol 1995, 50: 287-97.
19. D-Met2,Pro5)enkephalinamide. Eur J Pharmacol 1982, 85: 171-6.
20. Karalis, K., Mastokaros, G., Chrousos, G.P., Tolis, G. Somatostatin analogues suppress the inflammatory reaction in vivo. J Clin Invest 1994, 93: 2000-6.
21. Fioravanti, A., Govoni, M., La Montagna, G., Perpignano, G., Tirri, G., Trotta, F., Bogliolo, A., Ciocci, A., Tauceri, M.T., Marcolongo, R. Somatostatin-14 and joint inflammation: Evidence for intra-articular efficacy of prolonged administration in rheumatoid arthritis. Drugs Exp Clin Res 1995, 21: 97-103.
22. Heppelmann, B., Pawlak, M. Inhibitory effect of somatostatin on the mechanosensitivity of articular afferents in normal and inflamed knee joints of the rat. Pain 1997, 73: 377-82.
23. Carlton, S.M., Du, J., Davidson, E., Zhou, S., Coggeshall, R.E. Somatostatin receptors on peripheral primary afferent terminals: Inhibition on sensitised nociceptors. Pain 2001, 90: 233-44.
24. Carlton, S.M., Du, J., Zhou, S., Coggeshall, R.E. Tonic control of peripheral cutaneous nociceptors by somatostatin receptors. J Neurosci 2001, 21: 4042-9.
25. Szolcsányi, J., Pintér, E., Helyes, Z. Sensocrine function of capsaicin-sensitive nociceptors mediated by somatostatin regulates against inflammation and hyperalgesia. In: Progress in Research Management. Hyperalgesia: Molecular Mechanisms and Clinical Implications, H.O. Handwerker and K. Brune (Eds.), IASP Press, 2004, 113-28.
26. Thán, M., Németh, J., Pintér, E., Szilvássy, Z., Helyes, Z., Szolcsányi, J. Anti-inflammatory effect and somatostatin release from capsaicin-sensitive vagal and sciatic fibres in rats and guinea pigs. Eur J Pharmacol 2000, 399: 251-8.
27. Szállási, Á., Blumberg, P.M. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999, 51: 159-211.
28. Szolcsányi, J. Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents. In: Molecular Pathomechanisms and New Trends in Drug Research, G. Kéri and J. Tóth (Eds.), Taylor and Francis, New York/Philadelphia, 2002, 319-33.
29. Misery, L. Skin, immunity and the nervous system. Br J Dermatol 1997, 137: 843-50.
30. Sicuteri, F., Raino, L., Geppetti, P. Substance P and endogenous opioids: How and where they could play a role in cluster headache. Cephalalgia 1983, 3: 143-5.
31. Pintér, E., Helyes, Z., Németh, J., Pórszász, R., Petho, G., Thán, M., Kéri, G., Horváth, A., Jakab, B., Szolcsányi, J. Pharmacological characterisation of the somatostatin analogue TT-232: Effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia. Naunyn-Schmied Arch Pharmacol 2002, 366: 142-50.
32. Eglezos, A., Andrews, P.V., Helme, R.D. In vivo inhibition of the rat primary antibody response to antigenic stimulation by somatostatin. Immunol Cell Biol 1993, 71: 125-9.
33. Berman, A.S., Chancellor-Freeland, C., Zhu, G., Black, P.H. Substance P primes murine peritoneal macrophages for an augmented pro-inflammatory cytokine response to lipopolysaccharide. Neuroimmunomodulation 1996, 3: 141-9.
34. van Hagen, P.M., Markusse, H.M., Lamberts, S.W., Kwekkeboom, D.J., Reubi, J.C., Krenning, E.P. Somatostatin receptor imaging. The presence of somatostatin receptors in rheumatoid arthritis. Arthritis Rheum 1994, 37: 1521-7.
35. Elliott, D.E., Li, J., Blum, A.M., Metwali, A., Patel, Y.C., Weinstock, J.V. SSTR2A is the dominant somatostatin receptor subtype by inflammatory cells, is widely expressed and directly regulates T cell IFN-γ release. Eur J Immunol 1999, 29: 2454-63.
36. Chowers, Y., Cahalon, L., Lahav, M., Schor, H., Tal, R., Bal-Meir, S., Levite, M. Somatostatin through its specific receptor inhibits spontaneous and TNF-α and bacteria-induced IL-8 and IL-1beta secretion from intestinal epithelial cells. J Immunol 2000, 165: 2955-61.
37. Szolcsányi, J. Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: Facts and scopes of an unorthodox neuroregulatory mechanism. Prog Brain Res 1996, 113: 343-59.
38. Helyes, Z., Pintér, E., Németh, J., Kéri, Gy., Thán, M., Oroszi, G., Horváth, A., Szolcsányi, J. Anti-inflammatory effect of synthetic somatostatin analogues in the rat. Br J Pharmacol 2001, 134: 1571-9.
39. Janecka, A., Zubrzycka, M., Janecki, T. Somatostatin analogs. J Pept Res 2001, 58: 91-107.
40. Kéri, G., Mezo, I., Vadász, Z. et al. Structure-activity relationship studies of novel somatostatin analogs with antitumor activity. Peptide Res 1993, 6: 281-8.
41. Kéri, G., Érchegyi, J., Horváth, A. et al. A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc Natl Acad Sci USA 1996, 93: 12513-8.
42. Steták, A., Csermely, P., Ullrich, A., Kéri, G. Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase and PKCδ. Biochem Biophys Res Comm 2001, 288: 564-72.
43. Lee, J.U., Hosotani, R., Wada, M. et al. Antiproliferative activity induced by the somatostatin analogue, TT-232, in human pancreatic cancer cells. Eur J Cancer 2002, 38: 1526-34.
44. Tejeda, M., Gaal, D., Barna, K., Csuka, O., Kéri, G. The antitumor activity of the somatostatin structural derivative (TT-232) on different human tumor xenografts. Anticancer Res 2003, 23: 4061-6.
45. Szende, B., Kéri, G. TT-232: A somatostatin structural derivative as a potent antitumor drug candidate. Anticancer Drugs 2003, 14: 585-8.
46. Vantus, T., Csermely, P., Teplán, I., Kéri, G. The tumor-selective somatostatin analog, TT-232 induces a biphasic activation of phosphotyrosine phosphatase activity in human colon cell line, SW620. Tumor Biol 1995, 16: 261-7.
47. Schloos, J., Raulf, F., Hoyer, D., Bruns, C. Identification and pharmacological characterization of somatostatin receptors in rat lung. Br J Pharmacol 1997, 121: 963-71.
48. Scheiman, J.M., Tillner, A., Pohl, T., Oldenburg, A., Angermuller, S., Gorlach, E., Engel, G., Usadel, K.H., Kusterer, K. Reduction of non-steroidal anti-inflammatory drug induced gastric injury and leucocyte endothelial adhesion by octreotide. Gut 1997, 6: 720-5.
49. Almási, R., Petho, G., Bölcskei, K., Szolcsányi, J. Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: A novel heat allodynia model sensitive to analgesics. Br J Pharmacol 2003, 139: 49-58.
50. Szolcsányi, J., Bölcskei, K., Szabó, Á. et al. Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic hyperalgesia. Eur J Pharmacol 2004, 498: 103-9.
51. Tjolsen, A., Berge, O.G., Hunskaar, S., Rosland, J.H., Hole, K. The formalin test: An evaluation of the method. Pain 1992, 51: 5-17.
52. Basbaum, A.L. Distinct neurochemical features of acute and persistent pain. Proc Natl Acad Sci USA 1999, 96: 7739-43.
53. Dellemijn, P. Are opioids effective in relieving neuropathic pain? Pain 1999, 80: 453-62.
54. Suzuki, R., Dickenson, A.H. Nerve injury-induced changes in opioid modulation of wide dynamic range dorsal column nuclei neurones. Neurosci 2002, 111: 215-28.
55. Weckbecker, G., Lewis, J., Albert, R., Schmidt, H.A., Hoyer, D., Bruns, C. Opportunities in somatostatin research: Biological, chemical and therapeutic aspects. Nat Rev Drug Discov 2003, 2: 999-1017.
56. Vantus, T., Kéri, G., Kriviczkiene, Z. et al. The somatostatin analogue TT-232 induces apoptosis in A431 cells: Sustained activation of stress-induced kinases and inhibition of signalling to extracellular signal-regulated kinases. Cell Signal 2001, 13: 717-25.
57. Lewin, G.R., Ritter, A.M., Mendell, L.M. Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci 1993, 13: 2136-48.
58. Caterina, M.J., Julius, D. The vanilloid receptor: A molecular gateway to the pain pathway. Annu Rev Neurosci 2001, 24: 487-517.
59. Spina, D., Shah, S., Harrison, S. Modulation of sensory function in the airways. Trends Pharmacol Sci 1998, 19: 460-6.
60. Traxler, P., Furet, P. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. Pharmacol Ther 1999, 82: 195-206.
61. Marabini, S., Matucci-Cerinic, M., Geppetti, P., Del Bianco, E., Marchesoni, A., Tosi, S., Cagnoni, M., Partsch, G. Substance P and somatostatin levels in rheumatoid arthritis, osteoarthritis and psoriatic arthritis synovial fluid. Ann NY Acad Sci 1991, 632: 435-42.
62. Fioravanti, A., Govoni, M., La Montagna, G., Perpignano, G., Tirri, G., Trotta, F., Bogliolo, A., Ciocci, A., Tauceri, M.T., Marcolongo, R. Somatostatin-14 and joint inflammation: Evidence for intra-articular efficacy of prolonged administration in rheumatoid arthritis. Drugs Exp Clin Res 1995, 21: 97-103.
63. Sanake, T., Suzuki, N. The role of somatostatin in the pathophysiology of rheumatoid arthritis. Clin Exp Rheumatol 1998, 16: 745-9.
64. Duby, J.J., Campbell, R.K., Seffer, S.M., White, J.R., Rasmursen, K.A. Diabetic neuropathy: An intensive review. Am J Health Syst Pharm 2004, 61: 160-73.