Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice

Blood

Volumn 106, Issue 4, 2005, Pages 1323-1329

  Kikuchi, Shuichi ^b   Amano, Hirofumi ^b   Amano, Eri ^b   Fossati Jimack, Liliane ^b   Santiago Raber, Marie Laure ^b   Moll, Thomas ^b   Ida, Akinori ^b   Kotzin, Brian L ^b   Izui, Shozo ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; AUTOIMMUNITY; CHROMOSOME 1; CHROMOSOME 17; CHROMOSOME 7; COHORT ANALYSIS; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC SUSCEPTIBILITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

EID: 23744445779     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2005-02-0558     Document Type: Article

References (47)

1. Helyer BJ, Howie JB. Spontaneous auto-immune disease in NZB/BI mice. Br J Haematol. 1963;9:119-131.
2. Linder E, Edgington TS. Antigen specificity of anti-erythrocyte autoantibody responses of NZB mice: identification and partial characterization of two erythrocyte surface autoantigens. J Immunol. 1972;108:1615-1623.
3. Shibata T, Berney T, Reininger L, et al. Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. Int Immunol. 1990;2:1133-1141.
4. Clynes R, Ravetch JV. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity. 1995;3:21-26.
5. Azeredo da Silveira S, Kikuchi S, Fossati-Jimack L, et al. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med. 2002;195:665-672.
6. Hayakawa K, Hardy RR, Parks DR, Herzenberg LA. The "Ly-1 B" cell subpopulation in normal, immunodefective, and autoimmune mice. J Exp Med. 1983;157:202-218.
7. Murakami M, Tsubata T, Okamoto M, et al. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature. 1992;357:77-80.
8. Murakami M, Tsubata T, Shinkura R, et al. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J Exp Med. 1994;180:111-121.
9. Hayakawa K, Hardy RR, Honda M, Herzenberg LA, Steinberg AD. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci U S A. 1984;81:2494-2498.
10. Hayakawa K, Asano M, Shinton SA, et al. Positive selection of natural autoreactive B cells. Science. 1999;285:113-116.
11. Ghaffar A, Playfair JHL. The genetic basis of autoimmunity in NZB mice studied by progeny-testing. Clin Exp Immunol. 1971;8:479-490.
12. Warner NL. Genetic control of spontaneous and induced anti-erythrocyte autoantibody production in mice. Clin Immunol Immunopathol. 1973;1:353-363.
13. Bocchieri MH, Cooke A, Smith JB, Weigert M, Riblet RJ. Independent segregation of NZB immune abnormalities in NZB × C58 recombinant inbred mice. Eur J Immunol. 1982;12:349-354.
14. Knight JG, Adams DD. Genes determining autoimmune disease in New Zealand mice. J Clin Lab Immunol. 1981;5:165-170.
15. Ozaki S, Honda H, Maruyama N, et al. Genetic regulation of erythrocyte autoantibody production in New Zealand black mice. Immunogenetics. 1983;18:241-254.
16. Ochiai K, Ozaki S, Tanino A, et al. Genetic regulation of anti-erythrocyte autoantibodies and splenomegaly in autoimmune hemolytic anemia-prone New Zealand black mice. Int Immunol. 2000;12:1-8.
17. Izui S, Iwamoto M, Fossati L, Merino R, Takahashi S, Ibnou-Zekri N. The Yaa gene model of systemic lupus erythematosus. Immunol Rev. 1995;144:137-156.
18. Hudgins CC, Steinberg RT, Klinman DM, Reeves MJP, Steinberg AD. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol. 1985;134:3849-3854.
19. Izui S, Higaki M, Morrow D, Merino R. The Y chromosome from autoimmune BXSB/MpJ mice induces a lupus-like syndrome in (NZW × C57BL/6)F1 male mice, but not in C57BL/6 male mice. Eur J Immunol. 1988;18:911-915.
20. Rozzo SJ, Allard JD, Choubey D, et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity. 2001;15:435-443.
21. Kikuchi S, Fossati-Jimack L, Moll T, et al. Differential role of three major NZB-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol. 2005;174:1111-1117.
22. Laporte C, Ballester B, Mary C, Izui S, Reininger L. The Sgp3 locus on mouse chromosome 13 regulates nephritogenic gp70 autoantigen and predisposes to autoimmunity. J Immunol. 2003;171:3872-3877.
23. Fossati-Jimack L, Reininger L, Chicheportiche Y, et al. High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. J Exp Med. 1999;190:1689-1696.
24. Mouse Genome Database. Available at: http://www.informatics.jax.org. Accessed February 1, 2005.
25. Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989;121:185-199.
26. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241-247.
27. Lajaunias F, Nitschke L, Moll T, et al. Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes. J Immunol. 2002;168:6078-6083.
28. Mathis DJ, Benoist C, Williams VE II, Kanter M, McDevitt HO. Several mechanisms can account for defective Ea gene expression in different mouse haplptypes. Proc Natl Acad Sci U S A. 1983;80:273-277.
29. Tedder TF, Tuscano J, Sato S, Kehrl JH. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Ann Rev Immunol. 1997;15:481-504.
30. a lupus-prone mice. J Immunol. 2000;165:2987-2996.
31. Lanoue A, Batista FD, Stewart M, Neuberger MS. Interaction of CD22 with α2,6-linked sialoglyco-conjugates: innate recognition of self to dampen B cell autoreactivity? Eur J Immunol. 2002;32:348-355.
32. Stamenkovic I, Seed B. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature. 1990;345:74-77.
33. Jiang Y, Hirose S, Sanokawa-Akakura R, et al. Genetically determined aberrant down-regulation of FcγRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int Immunol. 1999;11:1685-1691.
34. Xiu Y, Nakamura K, Abe M, et al. Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol. 2002;169:4340-4346.
35. Santiago-Raber ML, Baccala R, Haraldsson KM, et al. Type-1 interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med. 2003;197:777-788.
36. Wandstrat AE, Nguyen C, Limaye N, et al. Association of extensive polymorphisms in the SLAM/CD2gene cluster with murine lupus. Immunity. 2004;21:769-780.
37. Murakami M, Yoshioka H, Shirai T, Tsubata T, Honjo T. Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. Int Immunol. 1995;7:877-882.
38. Nisitani S, Tsubata T, Murakami M, Okamoto M, Honjo T. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J Exp Med. 1993;178:1247-1255.
39. Watanabe N, Ikuta K, Nisitani S, Chiba T, Honjo T. Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in fas-deficient antierythrocyte immunoglobulin transgenic mice. J Exp Med. 2002;196:141-146.
40. Atencio S, Amano H, Izui S, Kotzin BL. Separation of the NZB genetic contribution to lupus from NZB determined expansions of marginal zone B and B1a cells. J Immunol. 2004;172:4159-4166.
41. Merino R, Fossati L, Lacour M, Lemoine R, Higaki M, Izui S. H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol. 1992;22:295-299.
42. Cohen PL, Creech E, Nakul-Aquaronne D, et al. Antigen nonspecific effect of major histocompatibility complex haplotype on autoantibody levels in systemic lupus erythematosus-prone lpr mice. J Clin Invest. 1993;91:2761-2768.
43. Merino R, Iwamoto M, Gershwin ME, Izui S. The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB × BXSB)F1 hybrid mice. J Clin Invest. 1994;94:521-525.
44. Merino R, Iwamoto M, Fossati L, et al. Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E a chain. J Exp Med. 1993;178:1189-1197.
45. Creech EA, Nakul-Aquaronne D, Reap EA, et al. MHC genes modify systemic autoimmune disease. The role of the I-E locus. J Immunol. 1996;156:812-817.
46. Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ, Izui S. Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice. Proc Natl Acad Sci U S A. 1997;94:14654-14659.
47. Martinez-Soria E, Ibnou-Zekri N, Iwamoto M, Santiago-Raber ML, Kosco-Vilbois M, Izui S. Epitope-dependent inhibition of T-cell activation by the Ea transgene: an explanation for the transgene-mediated protection from murine lupus. J Immunol. 2004;173:2842-2848.