MHC genes modify systemic autoimmune disease: The role of the I-E locus

Journal of Immunology

Volumn 156, Issue 2, 1996, Pages 812-817

  Creech, Elizabeth A ^a   Nakul Aquaronne, Danièle ^a   Reap, Elizabeth A ^a   Cheek, Robert L ^a   Wolthusen, P Anne ^a   Cohen, Philip L ^a   Eisenberg, Robert A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; GENE EXPRESSION; GENE LOCUS; HAPLOTYPE; IRRADIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD95; AUTOANTIBODIES; AUTOIMMUNE DISEASES; FEMALE; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPHOID TISSUE; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; RADIATION CHIMERA; RECOMBINANT PROTEINS;

EID: 0030069844     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Goldstein, R., and F. C. Arnett. 1987. The genetics of rheumatic disease in man Rheu Dis. Clin. North Am. 13:487.
2. Olsen, M. L., R Goldstein, F. C. Arnett, M. Duvic, M. Pollack, and J D. Reveille. 1989. C4A gene deletion and HLA associations in black Americans with systemic lupus erythematosus Immunogenetics 30.27.
3. Fujisaku, A., M B. Trank, B. Neas, M. Reichlin, and J B. Harley. 1990 HLA-DQ gene complementation and other histocompatibility relationships in man with the anti-Ro/SSA autoantibody response of systemic lupus erythematosus J Clin Invest. 86 606.
4. Reveille, J D , K L Anderson, R E. Schrohenloher, R. T. Acton, and B O Barger. 1991. Restriction fragment length polymorphism analysis of HLA-DR. DQ, DP and C4 alleles in Caucasians with systemic lupus erythematosus. J. Rheumatol. 18:14.
5. Knight, J G., and D D Adams. 1978. Three genes for lupus nephritis in. NZB X NZW mice. J Exp. Med. 147:1653.
6. bm12 mice J. Immunol. 145.94
7. Merino, R., L. Fossati, M. Lacour, R. Lemoine, M. Higaki, and S. Izui. 1992 H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J. Immunol. 22:295.
8. Watanabe-Fukunaga, R , C I Brannan, N. G Copeland, N. A. Jenkins, and S. Nagata 1992. Lymphoproliferation disorder in mice explained by defect in Fas antigen that mediates apoptosis. Nature 356:314.
9. Cohen, P L , and R. A. Eisenberg. 1991 lpr and gld single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol 9:243.
10. Cohen, P. L., E Creech, D. Nakul-Aquaronne, R McDaniel, S. Ackler, R. G Rapoport, E S Sobel, and R. A. Eisenberg 1993 Antigen nonspecific effect of major histocompatibility complex haplotype on autoantibody levels in systemic lupus erythematosus-prone lpr mice J. Clin Invest. 91:2761.
11. Nishimoto, H , H Kikutani, K. Yamamura, and T. Kishimoto. 1987. Prevention of autoimmune insulitis by expression of I-E molecules m NOD mice. Nature 328:432
12. Reich, E P., R. S. Sherwin, O. Kanagawa, and C. A. Janeway, Jr 1989. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature 341:326.
13. d gene in C57BL/6 transgenic mice. Nature 36:67.
14. Fisher, C. L., R. A. Eisenberg, and P. L Cohen. 1988. Quantitation and IgG subclass distribution of antichromatin autoantibodies in SLE mice. Clin. Immunol. Immunopathol. 46.205.
15. Morris, S C., R L. Cheek, P. L. Cohen, and R. A. Eisenberg 1990. Autoantibodies in chronic graft versus hosts result from cognate T-B interaction. J. Exp. Med 171:503
16. Sobel, E. S , T. Katagiri, K. Katagiri, S C. Morris, P. L Cohen, and R A Eisenberg. 1991. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J. Exp. Med 173:1441
17. Kafatos, F. C., C. W. Jones, and A Efstratiadis. 1979 Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucleic Acids Res. 7:1541
18. Blin, N., and D. W. Stafford. 1976. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:2303.
19. Sobel, E. S., V. N. Kakkanaiah, M Kakkanaiah, R L. Cheek, P L. Cohen, and R. A. Eisenberg. 1994. T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted. J. Immunol. 152:6011.
20. Ceredig, R., J W Lowenthal, M. Nabholz, and H R MacDonald. 1985 Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells Nature 314:98.
21. Sarmiento, M , A. L Glasebrook, and F W Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement J. Immunol. 125.2665.
22. Kremmer, E , S Theirfelder, U Kummer, R. Lederer, and J. Mysliwietz. 1989 Neutralization of immunosuppression by antibodies against variable as well as constant regions of monoclonal anti-Thy-1 xenoantibodies and their ability to be suppressed by initial T cell depletion. Transplantation 47:641.
23. Izui, S., M. Iwamoto, L. Fossatt, R Merino, S Takahashi, and N. Ibnou-Zekri. 1995. The Yaa gene model of systemic lupus erythematosus. Immunol. Rev. 144.137.
24. Rudensky, A. Y., P. Preston-Hurlburt, S. Hong, A. Barlow, and C. A. Janeway, Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622.
25. Elliott, J I , and A. Cooke. 1992. The influence of I-E on the generation of autoantibody and specific suppression in rat erythrocyte-immunized mice. Scand. J. Immunol 35(5):511.
26. Ferro, M. E., M. Romero-Piffiguer, and C. M. Riera. 1990. Antigen-induced inhibition of autoimmune response to rat male accessory glands: distinct role of I-A and I-E-positive peritoneal cells. Eur. J. Immunol. 20:1007.
27. Pistoresi-Palencia, M. C., M. Romero-Piffiguer, and M. E Ferro. 1991. Effect of aging on the autoimmune response to rat male accessory glands: deficit of I-E-positive peritoneal cells capable of inducing suppression. Eur. J. Immunol. 21:1685
28. Shroff, K. E., K B. Sainis, S. R. Sengupta, and R. S. Kamat 1991. Major histocompatibility complex restriction of T-cell suppression of immune response to mycobacteria. Intnl. J. Lepr. 59:49.
29. Bradley, D. S., J. C. Jennette, P. L. Cohen, and R A. Eisenberg. 1994. Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci J Immunol. 152:1960
30. Merino, R., M Iwamoto, L. Fossati, P. Muniesa, K. Araki, S. Takahashi, J. Huarte, K-I. Uamamura, J-D. Vassalli, and S. Izui. 1993. Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E α chain J. Exp. Med. 178:1189.
31. Nishimoto, H., H. Kikutani, D. Yamamura, and T. Kishimoto 1987 Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice Nature 328:432.
32. Reich, E. P., R. S. Sherwin, O. Kanagawa, and C. A. Janeway, Jr. 1989. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature 341:326.
33. k transgene in BlO mice suppresses the development of myasthenia gravis Immunogenetics 31:241