High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia

Journal of Experimental Medicine

Volumn 190, Issue 11, 1999, Pages 1689-1696

  Fossati Jimack, Liliane ^a   Reininger, Luc ^b   Chicheportiche, Yves ^a   Clynes, Raphael ^c   Ravetch, Jeffrey V ^c   Honjo, Tasuku ^d   Izui, Shozo ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Aix Marseille university   (France)

^c ROCKEFELLER UNIVERSITY   (United States)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoantibody; Autoimmune hemolytic anemia; Fc receptor; Knockout mouse; Kupffer cell

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; CONTROLLED STUDY; ERYTHROPHAGOCYTOSIS; FLOW CYTOMETRY; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; CELL LINE; ERYTHROCYTES; FLOW CYTOMETRY; HEMOLYSIS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN SWITCH REGION; LIVER; MICE; MICE, INBRED BALB C; RECEPTORS, FC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; VARIATION (GENETICS);

EID: 0033430229     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.11.1689     Document Type: Article

References (34)

1. Cooke, L.A., N.A. Staines, A. Morgan, C. Moorhouse, and G. Harris. 1982. Haemolytic disease in mice induced by transplantation of hybridoma cells secreting monoclonal anti-erythrocyte autoantibodies. Immunology. 47:569-572.
2. Ozaki, S., R. Nagasawa, H. Sato, and T. Shirai. 1984. Hybridoma autoantibodies to erythrocytes from NZB mice and the induction of hemolytic anemia. Immunol. Lett. 8:115-119.
3. Caulfield, M.J., D. Stanko, and C. Calkins. 1989. Characterization of the spontaneous autoimmune (anti-erythrocyte) response in NZB mice using a pathogenic monoclonal autoantibody and its anti-idiotype. Immunology. 66:233-237.
4. Shibata, T., T. Berney, L. Reininger, Y. Chicheportiche, S. Ozaki, T. Shirai, and S. Izui. 1990. Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. Int. Immunol. 2:1133-1141.
5. - B-lymphocyte subpopulation. Immunology. 79:568-573.
6. Shlomchik, M.J., A. Marshak-Rothstein, C.B. Wolfowicz, T.L. Rothstein, and M.G. Weigert. 1987. The role of clonal selection and somatic mutation in autoimmunity. Nature. 328:805-811.
7. Shlomchik, M., M. Mascelli, H. Shan, M.Z. Radic, D.S. Pisetsky, A. Marshak-Rothstein, and M. Weigert. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265-292.
8. Tillman, D.M., N.-T. Jou, R.J. Hill, and T.N. Marion. 1992. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB × NZW)F1 mice. J. Exp. Med. 176:761-779.
9. Hirose, S., M. Wakiya, Y. Kawano-Nishi, J. Yi, R. Sanokawa, S. Taki, T. Shimamura, T. Kishimoto, H. Tsurui, H. Nishimura, and T. Shirai. 1993. Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus. Eur. J. Immunol. 23:2813-2820.
10. Jacobson, B.A., J. Sharon, H. Shan, M. Shlomchik, M.G. Weigert, and A. Marshak-Rothstein. 1994. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation. J. Immunol. 152:4489-4499.
11. Berney, T., T. Fulpius, T. Shibata, L. Reininger, J. Van Snick, H. Shan, M. Weigert, A. Marshak-Rothstein, and S. Izui. 1992. Selective pathogenicity of murine rheumatoid factors of the cryoprecipitable IgG3 subclass. Int. Immunol. 4:93-99.
12. Fulpius, T., F. Spertini, L. Reininger, and S. Izui. 1993. Immunoglobulin heavy chain constant region determines the pathogenicity and the antigen-binding activity of rheumatoid factor. Proc. Natl. Acad. Sci. USA. 90:2345-2349.
13. Clynes, R., and J.V. Ravetch. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity. 3:21-26.
14. Meyer, D., C. Schiller, J. Westermann, S. Izui, W.L.W. Hazenbos, J.S. Verbeek, R.E. Schmidt, and J.E. Gessner. 1998. FcγRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia. Blood. 92:3997-4002.
15. Takai, T., M. Li, D. Sylvestre, R. Clynes, and J.V. Ravetch. 1994. FcR γ chain deletion results in pleiotrophic effector cell defects. Cell. 76:519-529.
16. Okamoto, M., and T. Honjo. 1990. Nucleotide sequences of the gene/cDNA coding for anti-murine erythrocyte autoantibody produced by a hybridoma from NZB mouse. Nucleic Acids Res. 18:1895.
17. Neuberger, M.S. 1983. Expression and regulation of immunoglobulin heavy gene transfected into lymphoid cells. EMBO (Eur. Mol. Biol. Organ.) J. 2:1373-1378.
18. Simon, T., and K. Rajewsky. 1988. 'Enhancer-constitutive' vectors for the expression of recombinant antibodies. Nucleic Acids Res. 16:354.
19. Shimizu, A., N. Takahashi, Y. Yamawaki-Kataoka, Y. Nishida, T. Kataoka, and T. Honjo. 1981. Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature. 289:149-153.
20. Labit, C., and M. Pierres. 1984. Rat monoclonal antibodies to mouse IgG1, IgG2a, IgG2b, and IgG3 subclasses, and kappa chain isotypic determinants. Hybridoma. 3:163-169.
21. Garcia-Gonzalez, M., S. Bettinger, S. Ott, P. Olivier, J. Kadouche, and P. Pouletty. 1988. Purification of murine IgG3 and IgM monoclonal antibodies by euglobulin precipitation. J. Immunol. Methods. 111:17-23.
22. Sanger, F.S., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
23. Dale, G.L., and R.B. Daniels. 1991. Quantitation of immunoglobulin associated with senescent erythrocytes from the rabbit. Blood. 77:1096-1099.
24. Oliveira, G.G.S., S. Izui, C.T. Ravirajan, R.A.K. Mageed, P.M. Lydyard, C.J. Elson, and R.N. Barker. 1996. Diverse antigen specificity of erythrocyte-reactive monoclonal autoantibodies from NZB mice. Clin. Exp. Immunol. 105:313-320.
25. Weinshank, R.L., A.D. Luster, and J.V. Ravetch. 1988. Function and regulation of a murine macrophage-specific IgG Fc receptor, FcγR-α. J. Exp. Med. 167:1909-1925.
26. Sears, D.W., N. Osman, B. Tate, I.F.C. McKenzie, and P.M. Hogarth. 1990. Molecular cloning and expression of the mouse high affinity Fc receptor for IgG. J. Immunol. 144: 371-378.
27. Okamoto, M., M. Murakami, A. Shimizu, S. Ozaki, T. Tsubata, S.-I. Kumagai, and T. Honjo. 1992. A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175: 71-79.
28. Murakami, M., T. Tsubata, R. Shinkura, S. Nisitani, M. Okamoto, H. Yoshioka, T. Usui, S. Miyawaki, and T. Honjo. 1994. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med. 180:111-121.
29. Snapper, C.M., and J.J. Mond. 1993. Towards a comprehensive view of immunoglobulin class switching. Immunol. Today. 14:15-17.
30. Reininger, L., T. Radaszkiewicz, M. Kosco, F. Melchers, and A.G. Rolink. 1992. Development of autoimmune disease in SCID mice populated with long-term in vitro proliferating (NZB × NZW)F1 pre-B cells. J. Exp. Med. 176:1343-1353.
31. Reininger, L., T.H. Winkler, C.P. Kalberer, M. Jourdan, F. Melchers, and A.G. Rolink. 1996. Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB × NZW)F1 mice J. Exp. Med. 184:853-862.
32. Cohen, P.L., and R.A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243-269.
33. Tsubata, T., M. Murakami, and T. Honjo. 1994. Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice. Curr. Biol. 4:8-17.
34. Wofsy, D., and W.E. Seaman. 1985. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J. Exp. Med. 161:378-391.