Interaction of CD22 with α2,6-linked sialoglycoconjugates: Innate recognition of self to dampen B cell autoreactivity?

European Journal of Immunology

Volumn 32, Issue 2, 2002, Pages 348-355

  Lanoue, Astrid ^a   Batista, Facundo D ^a   Stewart, Mairi ^a   Neuberger, Michael S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Autoimmunity; B cell activation; CD22; Innate immunity; Sialoglycoconjugates

Indexed keywords

B LYMPHOCYTE ANTIGEN; CD22 ANTIGEN; GLYCOCONJUGATE; GLYCOPROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; SIALYLTRANSFERASE; AUTOANTIGEN; BETA D GALACTOSIDE ALPHA 2 6 SIALYLTRANSFERASE; BETA-D-GALACTOSIDE ALPHA 2-6-SIALYLTRANSFERASE; CD22 PROTEIN, MOUSE; CELL ADHESION MOLECULE; H 2KB PROTEIN, MOUSE; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; LECTIN; LEUKOCYTE ANTIGEN; LYSOZYME; MESSENGER RNA;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CELL SURFACE; CONTROLLED STUDY; EUKARYOTE; IMMUNOREACTIVITY; IMMUNOREGULATION; INFLAMMATION; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIALYLATION; SIGNAL TRANSDUCTION; TARGET CELL; ANIMAL; B LYMPHOCYTE; CELL LINE; CHEMISTRY; CHICKEN; CONFORMATION; GENE EXPRESSION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; RAT; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD22; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; CARBOHYDRATE CONFORMATION; CELL ADHESION MOLECULES; CELL LINE; CHICKENS; GENE EXPRESSION; GLYCOCONJUGATES; H-2 ANTIGENS; LECTINS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MURAMIDASE; RATS; RNA, MESSENGER; SIALYLTRANSFERASES;

EID: 0036008486     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200202)32:2<348::AID-IMMU348>3.0.CO;2-5     Document Type: Article

References (50)

1. Initiation and processing of signals from the B cell antigen receptor
2. Affinity dependence of the B cell response to antigen: A threshold: A ceiling, and the importance of off-rate
3. Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses
4. Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
5. Role of complement in induction of the allergic response
6. The role of complement in B cell activation and tolerance
7. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
8. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
9. Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM
10. Peripheral deletion of self-reactive B cells
11. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
12. B cells extract and present immobilized antigen: Implications for affinity discrimination
13. HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes
14. Association of CD22 with the B cell antigen receptor
15. CD22 associates with the human surface IgM-B-cell antigen receptor complex
16. Hyperresponsive B cells in CD22-deficient mice
17. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
18. CD22 regulates thymus-independent responses and the lifespan of B cells
19. CD22 is a negative regulator of B-cell receptor signalling
20. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
21. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in cd22a lupus-prone mice
22. Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recignition
23. Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells
24. The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes
25. Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands
26. Studies on the effect of inflammation on rat liver and serum sialyltransferase. Evidence that inflammation causes release of Gal beta 1 →4GlcNAc alpha 2 → 6 sialyltransferase from liver
27. Evolutionary considerations in relating oligosaccharide diversity to biological function
28. The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin
29. B cell are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen
30. Chromosome mapping and organization of the human beta-galactoside alpha 2,6-sialyltransferase gene. Differential and cell-type specific usage of upstream exon sequences in B-lymphoblastoid cells
31. The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant
32. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
33. Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin
34. B cells acquire antigen from target cells following synapse formation
35. A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: Implications for B-cell homing to the bone marrow
36. Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes
37. Constitutive endocytosis and degradation of CD22 by human B cells
38. Intracellular CD22 rapidly moves to the cell surface in a tyrosine kinase-dependent manner following antigen receptor stimulation
39. Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative pathway
40. Human alternative complement pathway: Membrane-associated sialic acid regulates the competition between B and beta1H for cell-bound C3b
41. Role of sialic acid in the resistance of Trypanosoma cruzi trypomastigotes to complement
42. A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae
43. Immune inhibitory receptors
44. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
45. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins
46. Multiple defects in the immune system of Lyn-deficient mice culminating in autoimmune disease
47. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
48. Establishment and characterization of BALB/c lymphoma lines with B cell properties
49. Immunoglobulin gene expression in transformed lymphoid cells
50. Regulated expression of an introduced MHC H-2K bm1 gene in murine embryonal carcinoma cells