Only low levels of exogenous N-acetyltransferase can be achieved in transgenic mice

Pharmacogenomics Journal

Volumn 5, Issue 4, 2005, Pages 255-261

  Cao, W ^a,c   Chau, B ^a   Hunter, R ^a   Strnatka, D ^a   McQueen, C A ^a   Erickson, R P ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c JINLING HOSPITAL   (China)

Author keywords

Aromatic amines; Folates; Gene regulation; N acetyltransferase; Transgenics

Indexed keywords

ACYLTRANSFERASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HOMOZYGOSITY; HUMAN; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CLONING, MOLECULAR; CYTOMEGALOVIRUS; HUMANS; ISOENZYMES; LIVER; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSGENES;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; MUS MUSCULUS;

EID: 23644432643     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500319     Document Type: Article

References (48)

1. Hein DW. Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutat Res 2002; 506/507: 65-77.
2. Glowinski IB, Weber WW, Fysh JM, Vaught JB, King CM. Evidence that arylhydroxamic acid N, O-acetyltransferase and the genetic polymorphic N-acetyltransferase are properties of the same enzyme in rabbit liver. J Biol Chem 1980; 255: 7883-7890.
3. Flammang TJ, Kadlubar FF. Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissues and species differences, other acyl donors and arylhydroxamic acid-dependent acetyltransferases. Carcinogenesis 1986; 7: 926-929.
4. Fretland AJ, Doll MA, Gray K, Feng Y, Hein DW. Cloning, sequencing and recombinant expression of NAT1, NAT2 and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and detoxification of aromatic amine carcinogens. Toxicol Appl Pharmacol 1997; 1432: 360-366.
5. Mattano SS, Land S, King CM, Weber WW. Purification and biochemical characterization of hepatic N-acetyltransferase from rapid and slow acetylator mice: identity with arylhydroxamic acid N,O-acetyltransferase and N-hydroxylamine O-acetyltransferase. Mol Pharmacol 1989; 35: 599-609.
6. Ward A, Summers M, Sim E. Purification of recombinant human NAT1 in E. coli. Biochem. Pharmacol 1995; 49: 1759-1767.
7. Smelt VA, Upton A, Adjaye J, Payton MA, Boulouvala S, Johnson N et al. Expression of arylamine N-acetyltransferases in pre-term placenta and in human pre-implantation embryos. Hum Mol Genet 2000; 9: 1101-1107.
8. Glowinski IB, Weber WW. Genetic regulation of aromatic amine N-acetylation in inbred mice. J Biol Chem 1982; 257: 1424-1430.
9. Mattano SS, Erickson RP, Nesbitt MN, Weber WW. Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase. J Heredity 1988; 79: 430-433.
10. Ohsako S, Ohtomi M, Sakamoto Y, Uyemara K, Deguchi T. Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells. J Biol Chem 1988; 263: 7534-7538.
11. Martell KJ, Vatsis KP, Weber WW. Molecular genetic basis of rapid and slow acetylation in mice. Mol Pharmacol 1991; 40: 218-227.
12. Martell KJ, Levy GN, Weber WW. Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products. Mol Pharmacol 1992; 42: 265-272.
13. Hein DW, Trinidad A, Yerokun T, Ferguson RJ, Kirlin WG, Weber WW. Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BI /6, A/J. AC571 and the rapid and slow acetylator A.B6 and B6. A congenic inbred mouse. Drug Metab Dispos 1988; 16: 341-347.
14. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xio GH et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 2000; 9: 29-42.
15. Estrada-Rodgers L, Levy GN, Weber WW. Substrate selectivity of mouse N-acetyltransferases 1, 2 and 3 expressed in COS-1 cell. Drug Metab Dispos 1998; 26: 502-505.
16. Payton M, Smelt V, Upton A, Sim E. A method for genotyping murine arylamine N-acetyltransferase type2 (NAT2): a gene expressed in preimplantation embryonic stem cells encoding an enzyme acetylating the folate catabolite p-aminobenzoylglutamate. Biochem Pharmacol 1999; 58: 779-785.
17. Fakis G, Boukouvala S, Buckle V, Payton M, Denning C, Sim E. Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2. Cytogenet Cell Genet 2000; 90: 134-138.
18. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xio GH et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 2000; 9: 29-42.
19. Cornish VA, Pinter K, Boukouvala S, Johnson N, Labrousse C, Payton M et al. Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene. Pharmacogenomics 2003; 3: 169-177.
20. Sugamori KS, Wong S, Gaedigk A, Yu V, Abramovici H, Rozmahel R et al. Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice. Mol Pharmacol 2003; 64: 170-179.
21. Leff MA, Epstein PN, Doll MA, Fretland A-J, Udaya-Sankar D, Rustan TD et al. Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse. J Pharmacol Exp Ther 1999; 290: 182-187.
22. Sim E, Pinter K, Mushtaq A, Upton A, Sandy J, Bhakta S et al. Arylamine N-acetyltransferases: a pharmacogenomics approach to drug metabolism and endogenous function. Biochem Soc Trans 2003; 31: 615-619.
23. Tannen RH, Weber WW. Rodent models of the human isoniazid acetylator polymorphism. Drug Metab Dispos 1979; 7: 274-279.
24. Palmiter RD, Brinster RL. Germ-line transformation of mice. Annu Rev Genet 1986; 20: 465-499.
25. Minchin RF. Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochemistry 1995; 307: 1-3.
26. Sim E, Payton M, Noble M, Minchin R. An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes. Hum Mol Genet 2000; 9: 2435-2441.
27. 2 folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools. J Nutr 1998; 128: 1896-1906.
28. McPardin J, Courtney G, McNulty H, Weir D, Scott J. The quantitative analysis of endogenous folate catabolites in human urine. Anal Biochem 1992; 206: 256-261.
29. Schirch V, Strong W. Interaction of folypolyglutamates with enzymes in one-carbon metabolism. Arch Biochem Biophys 1989; 269: 371-380.
30. Strong WB, Schirch V. In vitro conversion of formate to serine. Effect of tetrahydropteroylpolyglutamates and serine hydroxymethyltransferase on the rate of 10-fomyltetrahydrofolate synthetase. Biochemistry 1989; 28: 9430-9439.
31. Chu E, Allegra CJ. The role of thymidylate synthase as an RNA binding protein. BioEssays 1996; 18: 191-198.
32. Kitchens ME, Forsthoefel AM, Rafique Z, Spencer HT, Berger FG. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. J Biol Chem 1999; 274: 12544-12547.
33. McGuire JJ, Coward JK. Pteroyl-polyglutamates: biosynthesis, degradation and function. In: Blakley RL, Benkovic SJ (eds). Folates and Pterins. Wiley: New York, 1984, pp 135-190.
34. Blakley RL, Benkovic SJ. Folates and Pterins. Wiley: New York, 1984.
35. Ebisawa T, Deguchi T. Structure and restriction fragment length polymorphism of genes for human liver N-acetyltransferases. Biochem Biophys Res Commun 1991; 279: 1252-1257.
36. Butcher N, Arulpragasam A, Pope C, Minchin RF. Identification of a minimal promoter sequence for the human n-acetyltransferase type 1 gene that binds to AP-1 (activator protein 1) and YY-1 (Yin and Yang). Biochem J 2003; 376: 441-448.
37. Husain A, Barker DF, States JC, Doll MA, Hein DJ. Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1). Pharmacogenetics 2004; 14: 397-406.
38. Kent KR, Warshawsky D. Xenobiotic inducible regions of the human arylamine N-acetyltransferase 1 and 2 genes. Toxicol Lett 2003; 139: 11-23.
39. Boukoulava S, Price N, Plant KE, Sim E. Structure and transcriptional regulation of the Nat2 gene encoding for the drug metabolizing enzyme arylamine N-acetyltransferase type 2 in mice. Biochem J 2003; 375: 593-602.
40. Liu Y, Levy GN. Activation of heterocyclic amines by combinations of prostaglandin H synthase-1 and -2 with N-acetyltransferase 1 and 2. Cancer Lett 1998; 133: 115-123.
41. Schmidt EV, Christoph G, Zeller R, Leder P. The cytomegalovirus enhancer: a pan-active control element in transgenic mice. Mol Cell Biol 1990; 10: 4406-4411.
42. Furth PA, Hennighausen L, Baker C, Beatty B, Woychick R. The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice. Nucleic Acids Res 1991; 19: 6205-6208.
43. Yull FE, Wallace RM, Clark AJ. Restricted tissue-specific but correct developmental expression mediated by a short human α1AT promoter fragment in transgenic mice. Transgenic Res 1995; 4: 70-74.
44. Mattano SS, Weber WW. Kinetics of arylamine N-acetyltransferase in tissues from rapid and slow acetylator mice. Carcinogenesis 1987; 8: 133-137.
45. McQueen CA. Arylamine N-acetyltransferases. In: Costa LG, Maines MD, Reed DJ, Sasa S, Sipes IG (eds). Current Protocols in Toxicology. John Wiley and Sons: New York, 2001, pp 4.6.1-4.6.1.13.
46. McQueen CA, Chau B, Erickson RP, Tialkens RB, Philbert MA. The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver. Chem Biol Interact 2003; 146: 51-60.
47. Hein DW, Hirata M, Glowinski IB, Weber WW. Biochemical evidence for the coexistence of monomorphic and polymorphic N-acetyltransferase activities on a common protein in rabbit liver. J Pharmacol Exp Ther 1982; 220: 1-7.
48. Karsai A, Miller S, Platz S, Hauser MT. Evaluation of a home-made SYBR Green I reaction mixture for real-time PCR quantification of gene expression. Biotechniques 2002; 32: 790-796.