The Leptospira interrogans lexA gene is not autoregulated

Journal of Bacteriology

Volumn 187, Issue 16, 2005, Pages 5841-5845

  Cuñée, Jordi ^a   Cullen, Paul ^b   Mazon, Gerard ^c   Campoy, Susana ^c   Adler, Ben ^b   Barbe, Jordi ^a,c  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b MONASH UNIVERSITY   (Australia)

^c CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOREGULATION; BACTERIAL GENE; COMPUTER ANALYSIS; DNA FOOTPRINTING; GENE CONTROL; LEPTOSPIRA INTERROGANS; LEX A GENE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECA GENE;

BACTERIAL PROTEINS; BASE SEQUENCE; DNA FOOTPRINTING; DNA REPAIR; HOMEOSTASIS; LEPTOSPIRA INTERROGANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; SERINE ENDOPEPTIDASES; TRANSCRIPTION, GENETIC;

LEPTOSPIRA INTERROGANS;

EID: 23644432557     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.187.16.5841-5845.2005     Document Type: Article

References (21)

1. Beaber, J. W., B. Hochhut, and M. K. Waldor. 2004. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 427:72-74.
2. Campoy, S., M. Fontes, S. Padmanabhan, P. Cortes, M. Llagostera, and J. Barbe. 2003. LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus. Mol. Microbiol. 49:769-781.
3. Cullen, P. A., S. J. Cordwell, D. M. Bulach, D. A. Haake, and B. Adler. 2002. Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai. Infect. Immun. 70:2311-2318.
4. Erill, I., M. Escribano, S. Campoy, and J. Barbé. 2003. In silico analysis reveals substantial variability in the gene contents of the gamma Proteobacteria LexA-regulon. Bioinformatics 19:2225-2236.
5. Erill, I., M. Jara, N. Salvador, M. Escribano, S. Campoy, and J. Barbé. 2004. Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics. Nucleic Acids Res. 32:6617-6626.
6. Fraser, C. M., S. Casjens, W. M. Huang, G. G. Sutton, R. Clayton, et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390:580-586.
7. Fraser, C. M., S. J. Norris, G. M. Weinstock, O. White, G. G. Sutton, et al. 1998. Complete sequence of Treponema pallidum, the syphilis spirochete. Science 281:375-388.
8. Jara, M., C. Nuñez, S. Campoy, A. R. Fernández de Henestrosa, D. R. Lovley, and J. Barbé. 2003. Geobacter sulfurreducens has two autoregulated lexA genes whose products do not bind the recA promoter: differing responses of lexA and recA to DNA damage. J. Bacteriol. 185:2493-2502.
9. Kline, K. A., E. V. Sechman, E. P. Skaar, and H. S. Seifert. 2003. Recombination, repair and replication in the pathogenic Neisseria: the 3 R's of molecular genetics of two human-specific bacterial pathogens. Mol. Microbiol. 50:3-13.
10. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
11. Little, J. W. 1991. Mechanism of specific LexA cleavage: autodigestion and the role of RecA coprotease. Biochimie 73:411-421.
12. Luo, Y., R. A. Pfuetzner, S. Mosimann, M. Paetzel, E. A. Frey, M. Cherney, B. Kim, J. W. Little, and N. C. Strynadka. 2001. Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell 106:585-594.
13. Margulis, L. 1996. Archaeal-eubacterial mergers in the origin of Eukarya: phylogenetic classification of life. Proc. Natl. Acad. Sci. USA 93:1071-1076.
14. Mazon, G., J. M. Lucena, S. Campoy, A. R. Fernández de Henestrosa, P. Candau, and J. Barbé. 2003. LexA-binding sequences in gram-positive and cyanobacteria are closely related. Mol. Gen. Genomics 271:40-49.
15. Nascimiento, A. L., A. I. Ko, E. A. Martins, C. B. Monteriro-Vitorello, et al. 2004. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J. Bacteriol. 186:2164-2172.
16. Pabo, C. O., R. T. Sauer, J. M. Sturtevant, and M. Ptashne. 1979. The λ repressor contains two domains. Proc. Natl. Acad. Sci. USA 76:1608-1612.
17. Ren, S. X., G. Fu, X. G. Jiang, R. Zeng, Y. G. Miao, H. Xu, Y. X. Zhang, et al. 2003. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422:888-893.
18. Sassanfar, M., and J. W. Roberts. 1990. Nature of SOS-inducing signal in Escherichia coli. The involvement of DNA replication. J. Mol. Biol. 212:79-96.
19. Seshadri, R., G. S. Myers, H. Tettelin, J. A. Eisen, J. F. Heidelberg, et al. 2004. Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc. Natl. Acad. Sci. USA 101:5646-5651.
20. Walker, G. C. 1984. Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. Microbiol. Rev. 48:60-93.
21. Winterling, K. W., D. Chafin, J. J. Hayes, J. Sun, A. S. Levine, R. E. Yasbin, and R. Woodgate. 1998. The Bacillus subtilis DinR binding site: redefinition of the consensus sequence. J. Bacteriol. 180:2201-2211.