A polyketide synthase in glycopeptide biosynthesis. The biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 38370-38377

  Pfeifer, Volker ^a   Nicholson, Graeme J ^a   Ries, Johannes ^a   Recktenwald, Jürgen ^a   Schefer, Alexandre B ^a   Shawky, Riham M ^a   Schröder, Joachim ^b   Wohlleben, Wolfgang ^a   Pelzer, Stefan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BIOSYNTHESIS; GENES;

ACCUMULATION;

ENZYMES;

3,5 DIHYDROXYPHENYLACETIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; 3,5 DIHYDROXYPHENYLGLYOXYLIC ACID; ACETIC ACID DERIVATIVE; BALHIMYCIN; CARBON; CHALCONE SYNTHASE; ENOYL COENZYME A HYDRATASE; GLYCOPEPTIDE; GLYOXYLIC ACID DERIVATIVE; MALONYL COENZYME A; OXFENICINE; OXIDOREDUCTASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; VANCOMYCIN DERIVATIVE; 3,5-DIHYDROXYPHENYLGLYCINE; AMINO ACID; AMINO ACID RECEPTOR BLOCKING AGENT; BACTERIAL PROTEIN; DPGA PROTEIN, AMYCOLATOPSIS MEDITERRANEI; DRUG DERIVATIVE; GLYCINE; LONG CHAIN FATTY ACID COENZYME A LIGASE; MULTIENZYME COMPLEX; RESORCINOL DERIVATIVE; VANCOMYCIN;

ACTINOBACTERIA; ARTICLE; GENE CLUSTER; GENE INACTIVATION; GENE STRUCTURE; NOCARDIA MEDITERRANEA; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STREPTOMYCES LIVIDANS; TRANSAMINATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CHEMICAL MODEL; CHEMISTRY; DNA SEQUENCE; ENZYMOLOGY; GENE DELETION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; PLASMID; SITE DIRECTED MUTAGENESIS; STREPTOMYCES;

AMYCOLATOPSIS; AMYCOLATOPSIS MEDITERRANEI; NOCARDIA; STREPTOMYCES; STREPTOMYCES LIVIDANS;

AMINO ACIDS; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COENZYME A LIGASES; EXCITATORY AMINO ACID ANTAGONISTS; GENE DELETION; GLYCINE; GLYCOPEPTIDES; MODELS, CHEMICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; RESORCINOLS; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; VANCOMYCIN;

EID: 0035914455     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106580200     Document Type: Article

References (37)

1. Foldes, M., Monro, R., Sorrell, T. C., Shankar, S., and Toohey, M. (1983) J. Antimicrob. Chemother. 11, 21-26
2. Tenover, F. C. (1999) J. Hosp. Infect. 43, 3-7
3. Cooper, R. D. G., Snyder, N. J., Zweifel, M. J., Staszak, M. A., Wilkie, S. C., Nicas, T. I., Mullen, D. L., Butler, T. F., Rodriguez, M. J., Huff, R. C., and Thompson, R. C. (1996) J. Antibiot. (Tokyo) 49, 575-581
4. Nadkarni, S. R, Patel, M. V., Chatterjee, S., Vijayakumar, E. K. S., Desikan, K. R., Blumbach, J., and Ganguli, B. N. (1994) J. Antibiot. (Tokyo) 47, 334-341
5. Pelzer, S., Süssmuth, R. D., Heckmann, D., Recktenwald, J., Huber, P., Jung, G., and Wohlleben, W. (1999) Antimicrob. Agents Chemother. 43, 1565-1573
6. S. Pelzer, M. Huppert, W. Reichert, D. Heckmann und W. Wohlleben. (1997) J. Biotechnol. 56, 115-128
7. Süssmuth, R. D., Pelzer, S., Nicholson, G. J., Walk, T., Wohlleben, W., and Jung, G. (1999) Angew. Chem. Int. Ed. Engl. 111, 2096-2099
8. Bischoff, D., Pelzer, S., Höltzel, A., Nicholson, G. J., Stockert, S., Wohlleben, W., Jung, G., and Süssmuth, R. D. (2001) Angew. Chem. Int. Ed. Engl. 40, 1693-1696
9. Pelzer, S., Huber, P., Süssmuth, R. D., Recktenwald, J., Heckmann, D., and Wohlleben, W. (December 14, 2000) International Patent WO0077182 A1
10. Hammond, S. J., Williamson, M. P., Williams, D. H., Boeck, L. D., and Marconi, G. G. (1982) J. Chem. Soc. Chem. Commun. 344-346
11. Choroba, O., Williams, D. H., and Spencer, J. B. (2000) J. Am. Chem. Soc. 122, 5389-5390
12. Hubbard, B. K., Thomas, M. G., and Walsh, C. T. (2000) Chem. Biol. (Lond.) 42, 1-12
13. Schröder, J. (1997) Trends Plant Sci. 2, 373-378
14. Moore, B. S. and Hopke, J. N. (2001) Chem. Biochem. 2, 35-38
15. Funa, N., Ohnishi, Y., Fujii, I., Shibuya, M., Ebizuka, Y., and Horinouchi, S. (1999) Nature 400, 897-899
16. Bullock, W. O., Fernandez, J. M., and Short, J. M. (1987) Focus (Idaho) 5, 376-378
17. Olins, P. O., Devine, C. S., Rangwala, S. H., and Kavka, K. S. (1988) Gene 73, 227-235
18. Rosenberg, A. H., and Studier, F. W. (1987) Gene 56, 125-135
19. Muth, G., Wohlleben, W., and Pühler, A. (1988) Mol. Gen. Genet. 211, 424-429
20. Muth, G., Nußbaumer, B., Wohlleben, W., and Pühler, A. (1989) Mol. Gen. Genet. 219, 341-348
21. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
22. Hopwood, D. A., Bibb, M. J., Chater, K. F., Kieser, T., Bruton, C. J., Kieser, H. M., Lydiate, D. J., Smith, C. P., Ward, J. M., and Schrempf, H. (1985) Genetic Manipulations of Streptomyces: A Laboratory Manual, The John Innes Foundation, Norwich, UK
23. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
24. Laemmli, U. K. (1970) Nature 227, 680-685
25. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467
26. Staden, R. (1996) Mol. Biotechnol. 5, 233-241
27. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
28. Eckermann, S., Schröder, G., Schmidt, J., Strack, D., Edrada, R. A., Helariuatta, Y., Elomaa, P., Kotilainen, M., Kilpeläinen, I., Proksch, P., Teeri, T. H., and Schröder, J. (1998) Nature 396, 387-390
29. Ferrer, J. L., Jez, J. M., Bowman, M. E., Dixon, R. A., and Noel, J. P. (1999) Nat. Struct. Biol. 6, 775-784
30. Van Wageningen, A. M. A., Kirkpatrick, P. N., Williams, D. H., Harris, B. R., Kershaw, J. K., Lennard, N. J., Jones, M., Jones, S. J. M., and Solenberg, P. J. (1998) Chem. Biol. (Lond.) 5, 155-162
31. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., III, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, S., Osborne, J., Quail, M. A., Rajandream, M. A., Rogers, J., Rutter, S., Seeger, K., Skelton, S., Squares, S., Sqares, R., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Nature 393, 537-544
32. Redenbach, M., Kieser, H. M., Denapaite, D., Eichner, A., Cullum, J., Kinashi, H., and Hopwood, D. A. (1996) Mol. Microbiol. 21, 77-96
33. Boynton, Z. L., Bennet, G. N., and Rudolph, F. B. (1996) J. Bacteriol. 178, 3015-3024
34. Henne, A., Daniel, R., Schmitz, R. A., and Gottschalk, G. (1999) Appl. Environ. Microbiol. 65, 3901-3907
35. Eichler, K., Bourgis, F., Buchet, A., Kleber, H. P., and Mandrand-Berthelot, M. A. (1994) Mol. Microbiol. 13, 775-786
36. Chen, H., Thomas, M. G., Hubbard, B. K., Losey, H. C., Walsh, C. T., and Burkart, M. D. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 11942-11947
37. Hopwood, D. A., and Sherman, D. H. (1990) Annu. Rev. Genet. 24, 37-66