Impact of in ovo-administered lead and testosterone on developing female thymocytes

Journal of Toxicology and Environmental Health - Part A

Volumn 68, Issue 15, 2005, Pages 1309-1319

  Hussain, Irshad ^a   Piepenbrink, Michael S ^a   Dietert, Rodney R ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALCOHOL; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; LEAD ACETATE; T LYMPHOCYTE RECEPTOR; TESTOSTERONE; LEAD;

ANIMAL CELL; ARTICLE; BIOLOGICAL MODEL; CELL DISRUPTION; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; EMBRYO; FEMALE; FLOW CYTOMETRY; FOWL; HELPER CELL; IMMUNOTOXICITY; NONHUMAN; OOCYTE; PHENOTYPE; PRIORITY JOURNAL; THYMOCYTE; ANIMAL; CD4 LYMPHOCYTE COUNT; CHICK EMBRYO; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; MALE; THYMUS;

ANIMALIA; AVES;

ANIMALS; ANTIGENS, CD8; CD4 LYMPHOCYTE COUNT; CHICK EMBRYO; FEMALE; FLOW CYTOMETRY; LEAD; MALE; TESTOSTERONE; THYMUS GLAND;

EID: 23444439491     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390590953554     Document Type: Article

References (45)

1. Bloom, S. E., and Hsu, T. C. 1975. Differential fluorescence of sister chromatids in chicken embryos exposed to 5-bromodeoxyuridine. Chromosoma 51:261-267.
2. Blyler, G., Landreth, K. S., and Barnett, J. B. 1994. Gender-specific effects of prenatal chlordane exposure on myeloid cell development. Fundam. Appl. Toxicol. 23:188-193.
3. Bucy, R. P., Chen, C. H., and Cooper, M. D. 1990. Ontogeny of T cell receptors in the chicken thymus. J. Immunol. 144:1161-1168.
4. Bunn, T. L., Marsh, J. A., and Dietert, R. R. 2000. Gender differences in developmental immunotoxicity to lead in the chicken: analysis following a single early low-level exposure in ovo. J. Toxicol. Environ. Health A 61:677-693.
5. Bunn, T. L., Parsons, P. J., Kao, E., and Dietert, R. R. 2001. Exposure to lead during critical windows of embryonic development: Differential immunotoxic outcome based on stage of exposure and gender. Toxicol. Sci. 64:57-66.
6. Burgess, S. C., and Davison, T. F. 1999. Counting absolute numbers of specific leukocyte subpopulations in avian whole blood using a single-step flow cytometric technique: comparison of two inbred lines of chickens. J. Immunol. Methods 227:169-176.
7. Burke, W. H. 1996. Effects of in ovo injection of a anti-androgen on embryonic and posthatching growth of broiler chicks. Poult. Sci. 75:648-655.
8. Chan, M. M., Chen, C. -L., Ager, L. A., and Cooper, M. D. 1988. Identification of the avian homologues of mammalian CD4 and CD8 antigens. J. Immunol. 140:2133-2138.
9. Chapin, R. E., Harris, M. W., Davis, B. J., Ward, S. M., Wilson, R. E., Mauney, M. A., Lockhart, A. C., Smialowicz, R. J., Moser, V. C., Burka, L. T., and Collins, B. J. 1997. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam. Appl. Toxicol. 40:138-157.
10. Char, D., Sanchez, P., Chen, C. L., Bucy, R. P., and Cooper, M. D. 1990. A third sublineage of avian T cells can be identified with a T cell receptor-3-specific antibody. J. Immunol. 145:3547-3555.
11. Chen, S., Golemboski, K. A., Sanders, F. S., and Dietert, R. R. 1999. Persistent effect of in utero meso-2,3- dimercaptosuccinic acid (DMSA) on immune function and lead-induced immunotoxicity. Toxicology 132:67-79.
12. Coltey, M., Jotereau, F. V., and Douarin, N. M. 1987. Evidence of cyclic renewal of lymphocyte precursor cells in the embryonic chick thymus. Cell Differ. 22:71-82.
13. Dietert, R. R., Qureshi, M. A., Nanna, U. C., and Bloom, S. E. 1985. Embryonic exposure to alflatoxin-B1 : Mutagenicity and influence on development and immunity. Environ. Mutagen. 7:715-725.
14. Dietert, R. R., Lee, J. E., Hussain, I., and Piepenbrink, M. 2004. Developmental immunotoxicology of lead. Toxicol. Appl. Pharmacol. 198:86-94.
15. Dunon, D., Allioli, N., Vanio, O., Ody, C., and Imhof, B. A. 1999. Quantification of T-cell progenitors during ontogeny: Thymus colonization depends on blood delivery of progenitors. Blood 93:2234-2243.
16. Fox, L. L., and Grasman, K. A. 1999. Effects of PCB 126 on primary immune organ development in chicken embryos. J. Toxicol. Environ. Health A 58:233-244.
17. Gandi, M., Aweeka, F., Greenblat, R. M., and Blaschke, T. F. 2004. Sex differences in pharmacokinetics and pharmacodynamics. Annu Rev Pharmacol Toxicol 44:499-523.
18. Grasman, K. A., and Whitacre, L. L. 2001. Effects of PCB 126 on thymocyte surface marker expression and immune organ development in chicken embryos. J. Toxicol. Environ. Health A 62:191-206.
19. Hamilton, J. W., and Bloom, S. E. 1984. Correlation between mixed-function oxidase enzyme induction and aflatoxin B1-induced unscheduled DNA synthesis in the chick embryo, in vivo. Environ. Mutagen. 6:41-48.
20. Heller, A., Bubula, N., Lew, R., and Won, L. 2001. Gender-dependent enhanced adult neurotoxic response to methamphetamine following fetal exposure to the drug. J. Pharmacol. Exp. Ther. 298:769-779.
21. Henry, M. H., and Burke, W. H. 1999. The effects of in ovo administration of testosterone or an antiandrogen on growth of chick embryos and embryonic muscle characteristics. Poult. Sci. 78:1006-1013.
22. Heo, Y., Parson, P. J., and Lawrence, D. A. 1996. Lead differentially modifies cytokine production in vitro and in vivo. Toxicol. Appl. Pharmacol. 138:149-157.
23. Heo, Y., Lee, W. T., and Lawrence, D. A. 1997. In vivo the environmental pollutants lead and mercury induce oligoclonal T cell responses skewed toward Type-2 reactivities. Cell. Immunol. 179:185-195.
24. Heo, Y., Lee, W. T., and Lawrence, D. A. 1998. Differential effect of lead and cAMP on the development of Th1-and Th2-lymphocytes. Toxicol. Sci. 43:172-185.
25. Huber, S. A., Kupperman, J., and Newell, M. K. 1999. Estrdiol prevents and testosterone promotes Fas-depedent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression. Lupus 8:384-387.
26. Lampisuo, M., Liippo, J., Vanio, O., McNagny, K. M., Kulmala, J., and Lassila, O. 1999. Characterization of prethymic progenitors within the chicken embryo. Int. Immunol. 11:63-69.
27. Lee, J. E., and Dietert, R. R. 2003. Developmental immunotoxicity of lead: Impact on thymic function. Birth Defects Res. A 67:861-867.
28. Lee, J. E., Chen, S., Golemboski, K. A., Parsons, P. J., and Dietert, R. R. 2001. Developmental windows of differential lead-induced immunotoxicity in chickens. Toxicology 156:161-170.
29. Lee, J. E., Naqi, S. A., Kao, E., and Dietert, R. R. 2002. Embryonic exposure to lead: Comparison of immune and cellular responses in unchallenged and virally stressed chickens. Arch. Toxicol. 75:717-724.
30. Levin, E. D., Addy, N., Baruah, A., Elias, A., Christopher, N. C., Seidler, F. J., and Slotkin, T. A. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol. Teratol. 24:733-741.
31. Luebke, B., Chen, D., Dietert, R., King, M., Yang, Y., and Luster, M. 2004. Increased sensitivity of the developing immune system to xenobiotics: Experimental evidence supporting the concept of developmental immunotoxicity testing guidelines. J. Toxicol. Environ. Health B (in press).
32. Markowski, V. P., Cox, C., and Weiss, B. 1998. Prenatal cocaine exposure produces gender-specific motor effects in aged rats. Neurotoxicol. Teratol. 20:43-53.
33. Miller, T. E., Golemboski, K. A., Ha, R. S., Bunn, T., Sanders, F. S., and Dietert, R. R. 1998. Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats. Toxicol. Sci. 42:129-135.
34. Motobu, M., El-Abasy, M., Na, K. J., Vanio, O., Toivanen, P., and Hirota, Y. 2003. Effects of 6-hydroxydopamine on the development of the immune system in chickens. J. Vet. Med. Sci. 65:35-42.
35. Rodenberg, J., Sharma, J. M., Belzer, S. W., Nordgren, R. M., and Naqi, S. 1994. Flow cytometric analysis of B cell and T cell subpopulations in specific-pathogen-free chickens infected with infectious bursal disease virus. Avian Dis. 38:16-21.
36. Rossi, A. D., Ahlbom, E., Ogren, S. O., Nicotera, P., and Ceccatelli, S. 1997. Prenatal exposure to methylmercury alters locomotor activity of male but not female rats. Exp.Brain Res. 117:428-436.
37. SAS Institute Inc. 2001. SAS Users guide: Statistics, Version 8. 2001. Cary, NC: SAS Institute, Inc.
38. Seo, B. W., Sparks, A. J., Medora, K., Amin, S., and Schantz, S. L. 1999. Learning and memory in rats gestationally and lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Neurotoxicol. Teratol. 21:231-239.
39. Smialowicz, R. J., Williams, W. C., Copeland, C. B., Harris, M. W., Overstreet, D., Davis, B. J., and Chapin, R. E. 2001. The effects of perinatal/juvenile hetachlor exposure on adult immune and reproductive system function in rats. Toxicol. Sci. 61:164-175.
40. Snyder, J. E., Filipov, N. M., Parsons, P. J., and Lawrence, D. A. 2000. The efficiency of maternal transfer of lead and its influence on plasma lgE and splenic cellularity of mice. Toxicol. Sci. 57:87-94.
41. Sowder, J. T., Chen, C. L., Ager, L. L., Chan, M. M., and Cooper, M. D. 1988. A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor. J. Exp. Med. 167:315-322.
42. Vega, L., Montes, P., Saavedra, R., and Ostrotsky-Wegman, P. 2004. Helper T cell subpopulations from women are more susceptible to the toxic effects of sodium arsenite in vitro. Toxicology 199:121-128.
43. Wilmer, J. L., and Bloom, S. E. 1991. A cytogenetic approach for detecting the selective toxicity of drugs in avian embryonic B and T lymphocytes. Mutat. Res. 253:161-172.
44. Woods, J. E., and Brazzill, D. M. 1981. Plasma 17 beta-estradiol levels in the chick embryo. Gen. Comp. Endocrinol. 44:37-43.
45. Woods, J. E., Simpson, R. M., and Moore, P. L. 1975. Plama testosterone levels in the chick embryo. Gen. Comp. Endocrinol. 27:543-547.