High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis

Arthritis Research and Therapy

Volumn 5, Issue 5, 2003, Pages

  Ruschpler, Peter ^a   Lorenz, Peter ^b   Eichler, Wolfram ^c   Koczan, Dirk ^b   Hänel, Claudia ^a   Scholz, Roger ^a   Melzer, Christian ^d   Thiesen, Hans Jürgen ^b   Stiehl, Peter ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d 'Waldkrankenhaus'   (Germany)

Author keywords

chemokines; CXCR3; inflammation; mast cells; rheumatoid arthritis; synovial tissue

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CXC CHEMOKINE IP 10; CXC CHEMOKINE IP-10; CXC CHEMOKINE RECEPTOR 3; CXCL9 PROTEIN, HUMAN; MESSENGER RNA; SIGNAL PEPTIDE;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; MAST CELL; METABOLISM; METHODOLOGY; OSTEOARTHRITIS; PATHOLOGY; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; TISSUE DISTRIBUTION;

ARTHRITIS, RHEUMATOID; CHEMOKINES, CXC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; OSTEOARTHRITIS; RECEPTORS, CHEMOKINE; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; RNA, MESSENGER; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; TISSUE DISTRIBUTION;

EID: 2342613015     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar783     Document Type: Article

References (58)

1. Gay S, Gay RE, Koopman WJ: Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?. Ann Rheum Dis. 1993, 52: 39-47. DOI: 10.1136/ard.52.Suppl_1.S39
2. Muller-Ladner U: Molecular and cellular interactions in rheumatoid synovium. Curr Opin Rheumatol. 1996, 8: 210-220. DOI: 10.1097/00002281-199605000-00008
3. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994, 76: 301-314. 10.1016/0092-8674(94)90337-9. DOI: 10.1016/0092-8674(94)90337-9
4. Kunkel SL: Through the looking glass: the diverse in vivo activities of chemokines. J Clin Invest. 1999, 104: 1333-1334. DOI: 10.1172/JCI8511
5. Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest. 1998, 101: 746-754. DOI: 10.1172/JCI1422
6. Murdoch C, Finn A: Chemokine receptors and their role in inflammation and infectious diseases. Blood. 2000, 95: 3032-3043.
7. Murray K, Thompson SD, Glass DN: Pathogenesis of juvenile chronic arthritis: genetic and environmental factors. Arch Dis Child. 1997, 77: 530-534. DOI: 10.1136/adc.77.6.530
8. Pitzalis C, Kingsley G, Haskard D, Panayi G: The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. Eur J Immunol. 1988, 18: 1397-1404. DOI: 10.1002/eji.1830180915
9. Godfrey HP, Ilardi C, Engber W, Graziano FM: Quantitation of human synovial mast cells in rheumatoid arthritis and other rheumatic diseases. Arthritis Rheum. 1984, 27: 852-856. DOI: 10.1002/art.1780270803
10. Okada Y: The mast cells in synovial membrane of patients with joint disease. Japanese J Ortho Surg. 1973, 47: 657-674.
11. Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A, Hamann A: P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Nature. 1997, 385: 81-83. 10.1038/385081a0. DOI: 10.1038/385081a0
12. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998, 187: 129-134. 10.1084/jem.187.1.129. DOI: 10.1084/jem.187.1.129
13. Sallusto F, Mackay CR, Lanzavecchia A: Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science. 1997, 277: 2005-2007. 10.1126/science.277.5334.2005. DOI: 10.1126/science.277.5334.2005
14. Siveke JT, Hamann A: T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol. 1998, 160: 550-554.
15. Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ: Lymphotactin: a cytokine that represents a new class of chemokine. Science. 1994, 266: 1395-1399. DOI: 10.1126/science.7973732
16. Luster AD, Ravetch JV: Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). J Exp Med. 1987, 166: 1084-1097. 10.1084/jem.166.4.1084. DOI: 10.1084/jem.166.4.1084
17. + T lymphocytes into inflamed joints of rheumatoid arthritis. Int Immunol. 1999, 11: 553-559. 10.1093/intimm/11.4.553. DOI: 10.1093/intimm/11.4.553
18. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med. 1998, 187: 875-883. 10.1084/jem.187.6.875. DOI: 10.1084/jem.187.6.875
19. Wedderburn LR, Robinson N, Patel A, Varsani H, Woo P: Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis. Arthritis Rheum. 2000, 43: 765-774. 10.1002/1529-0131(200004)43:4<765::AID-ANR7>3.0.CO;2-B. DOI: 10.1002/1529-0131(200004)43:4<765::AID-ANR7>3.0.CO;2-B
20. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996, 184: 963-969. 10.1084/jem.184.3.963. DOI: 10.1084/jem.184.3.963
21. Loetscher M, Loetscher P, Brass N, Meese E, Moser B: Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization. Eur J Immunol. 1998, 28: 3696-3705. 10.1002/(SICI)1521-4141(199811)28:11<3696::AID-IMMU3696>3.3.CO;2-N. DOI: 10.1002/(SICI)1521-4141(199811)28:11<3696::AID-IMMU3696>3.0.CO;2-W
22. Farber JM: HuMig: a new human member of the chemokine family of cytokines. Biochem Biophys Res Commun. 1993, 192: 223-230. 10.1006/bbrc.1993.1403. DOI: 10.1006/bbrc.1993.1403
23. Piali L, Weber C, LaRosa G, Mackay CR, Springer TA, Clark-Lewis I, Moser B: The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur J Immunol. 1998, 28: 961-972. 10.1002/(SICI)1521-4141(199803)28:03<961::AID-IMMU961>3.0.CO;2-4. DOI: 10.1002/(SICI)1521-4141(199803)28:03<961::AID-IMMU961>3.0.CO;2-4
24. Ruth JH, Rottman JB, Katschke KJ, Qin S, Wu L, LaRosa G, Ponath P, Pope RM, Koch AE: Selective lymphocyte chemokine receptor expression in the rheumatoid joint. Arthritis Rheum. 2001, 44: 2750-2760. 10.1002/1529-0131(200112)44:12<2750::AID-ART462>3.0.CO;2-C. DOI: 10.1002/1529-0131(200112)44:12<2750::AID-ART462>3.0.CO;2-C
25. Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K, Yoshie O: Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol. 1999, 11: 81-88. 10.1093/intimm/11.1.81. DOI: 10.1093/intimm/11.1.81
26. Garcia-Lopez MA, Sanchez-Madrid F, Rodriguez-Frade JM, Mellado M, Acevedo A, Garcia MI, Albar JP, Martinez C, Marazuela M: CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells. Lab Invest. 2001, 81: 409-418. DOI: 10.1038/labinvest.3780248
27. Jinquan T, Jing C, Jacobi HH, Reimert CM, Millner A, Quan S, Hansen JB, Dissing S, Malling HJ, Skov PS, Poulsen LK: CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma. J Immunol. 2000, 165: 1548-1556. DOI: 10.4049/jimmunol.165.3.1548
28. Kunkel SL, Lukacs N, Kasama T, Strieter RM: The role of chemokines in inflammatory joint disease. J Leukoc Biol. 1996, 59: 6-12.
29. Lukacs NW, Kunkel SL: Chemokines and their role in disease. Int J Clin Lab Res. 1998, 28: 91-95. 10.1007/s005990050025. DOI: 10.1007/s005990050025
30. Tuschil A, Lam C, Haslberger A, Lindley I: Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation. J Invest Dermatol. 1992, 99: 294-298. 10.1111/1523-1747.ep12616634. DOI: 10.1111/1523-1747.ep12616634
31. Schonbeck U, Brandt E, Petersen F, Flad HD, Loppnow H: IL-8 specifically binds to endothelial but not to smooth muscle cells. J Immunol. 1995, 154: 2375-2383.
32. Schulz BS, Michel G, Wagner S, Suss R, Beetz A, Peter RU, Kemeny L, Ruzicka T: Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro. J Immunol. 1993, 151: 4399-4406.
33. Kraan MC, Patel DD, Haringman JJ, Smith MD, Weedon H, Ahern MJ, Breedveld FC, Tak PP: The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8). Arthritis Res. 2001, 3: 65-71. 10.1186/ar141. DOI: 10.1186/ar141
34. Baggiolini M, Dewald B, Moser B: Human chemokines: an update. Annu Rev Immunol. 1997, 15: 675-705. 10.1146/annurev.immunol.15.1.675. DOI: 10.1146/annurev.immunol.15.1.675
35. Dolhain RJ, ter Haar NT, Hoefakker S, Tak PP, de Ley M, Claassen E, Breedveld FC, Miltenburg AM: Increased expression of interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis. Br J Rheumatol. 1996, 35: 24-32. DOI: 10.1093/rheumatology/35.1.24
36. Stiehl P: Histologie der Rheumatoid-Arthritis. Beitrag zur diagnostischen und pathogenetischen Heterogenität, zur Aktivitätsdiagnose und Prognose. In: Arthritiden. Edited by: Sack U. 1997, Lengerich: Pabst Science Publishers, 5: 188-200.
37. Ruschpler P, Stiehl P: Shift in Th1 (IL-2 and IFN-gamma) and Th2 (IL-10 and IL-4) cytokine mRNA balance within two new histological main-types of rheumatoid-arthritis (RA). Cell Mol Biol. 2002, 48: 285-293.
38. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. DOI: 10.1002/art.1780310302
39. Geiler G, Stiehl P: Significance of the concepts basic activity and actual activity in the morphological evaluation of synovial membranes in rheumatoid arthritis. Z Rheumatol. 1974, 33: 73-86.
40. Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA. 1997, 94: 2150-2155. 10.1073/pnas.94.6.2150. DOI: 10.1073/pnas.94.6.2150
41. Grotzer MA, Patti R, Geoerger B, Eggert A, Chou TT, Phillips PC: Biological stability of RNA isolated from RNAlater-treated brain tumor and neuroblastoma xenografts. Med Pediatr Oncol. 2000, 34: 438-442. 10.1002/(SICI)1096-911X(200006)34:6<438::AID-MPO12>3.0.CO;2-Q. DOI: 10.1002/(SICI)1096-911X(200006)34:6<438::AID-MPO12>3.0.CO;2-Q
42. Konttinen YT, Reitamo S, Ranki A, Hayry P, Kankaanapaa U, Wegelius O: Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections and eluates. Arthritis Rheum. 1981, 24: 71-79. DOI: 10.1002/art.1780240112
43. Taub DD, Lloyd AR, Conlon K, Wang JM, Ortaldo JR, Harada A, Matsushima K, Kelvin DJ, Oppenheim JJ: Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med. 1993, 177: 1809-1814. 10.1084/jem.177.6.1809. DOI: 10.1084/jem.177.6.1809
44. Tetlow LC, Woolley DE: Distribution, activation and tryptase/ chymase phenotype of mast cells in the rheumatoid lesion. Ann Rheum Dis. 1995, 54: 549-555. DOI: 10.1136/ard.54.7.549
45. Gruber BL, Kaplan AP: Mast cells and rheumatic diseases. In: Arthritis and Allied Conditions. Edited by: McCarty DJ, Koopmann WJ. 1993, Philadelphia: Lea & Febiger, 417-429.
46. Galli SJ: New concepts about the mast cell. N Engl J Med. 1993, 328: 257-265. 10.1056/NEJM199301283280408. DOI: 10.1056/NEJM199301283280408
47. Tetlow LC, Woolley DE: Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies. Ann Rheum Dis. 1995, 54: 896-903. DOI: 10.1136/ard.54.11.896
48. Lees M, Taylor DJ, Woolley DE: Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B. Eur J Biochem. 1994, 223: 171-177. 10.1111/j.1432-1033.1994.tb18980.x. DOI: 10.1111/j.1432-1033.1994.tb18980.x
49. Saarinen J, Kalkkinen N, Welgus HG, Kovanen PT: Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. J Biol Chem. 1994, 269: 18134-18140.
50. TC subset with matrix turnover and clinical progression. Arthritis Rheum. 1997, 40: 479-489. DOI: 10.1002/art.1780400314
51. Woolley DE: Mast cells in rheumatoid lesion: ringleaders or innocent bystanders?. Ann Rheum Dis. 1995, 54: 533-534. DOI: 10.1136/ard.54.7.533
52. Wang HW, Tedla N, Lloyd AR, Wakefield D, McNeil PH: Mast cell activation and migration to lymph nodes during induction of an immune response in mice. J Clin Invest. 1998, 102: 1617-1626. DOI: 10.1172/JCI3704
53. Kitamura Y, Go S, Hatanaka K: Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood. 1978, 52: 447-452.
54. Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, Metcalfe DD: Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood. 1999, 94: 2333-2342.
55. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB: Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science. 2002, 297: 1689-1692. 10.1126/science.1073176. DOI: 10.1126/science.1073176
56. Belperio JA, Keane MP, Burdick MD, Lynch JP, Xue YY, Li K, Ross DJ, Strieter RM: Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. J Immunol. 2002, 169: 1037-1049. DOI: 10.4049/jimmunol.169.2.1037
57. Salomon I, Netzer N, Wildbaum G, Schif-Zuck S, Maor G, Karin N: Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis. J Immunol. 2002, 169: 2685-2693. DOI: 10.4049/jimmunol.169.5.2685
58. Kobayashi Y, Okunishi H: Mast cells as a target of rheumatoid arthritis treatment. Jpn J Pharmacol. 2002, 90: 7-11. 10.1254/jjp.90.7. DOI: 10.1254/jjp.90.7