Lymphocyte-specific chemokine receptor CXCR3: Regulation, chemokine binding and gene localization

European Journal of Immunology

Volumn 28, Issue 11, 1998, Pages 3696-3705

  Loetscher, Marcel ^a   Loetscher, Pius ^a   Brass, Nicole ^b   Meese, Eckart ^b   Moser, Bernhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Chromosomal localization; CXCR3; IP10; Mig; T lymphocyte

Indexed keywords

ANTIBODY; CD28 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHONDROITIN 6 SULFATE; INTERLEUKIN 2; LYMPHOCYTE RECEPTOR; MONOCLONAL ANTIBODY CD3; PHYTOHEMAGGLUTININ;

ARTICLE; CHROMOSOME XQ; CONTROLLED STUDY; GENE LOCATION; HUMAN; HUMAN CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR GENE; T LYMPHOCYTE;

CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; CHROMOSOME MAPPING; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES;

EID: 0031795273     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3696::AID-IMMU3696>3.0.CO;2-W     Document Type: Article

References (45)

1. Baggiolini, M., Dewald, B. and Moser, B., Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv. Immunol. 1994. 55: 97-179.
2. Baggiolini, M., Dewald, B. and Moser, B., Human chemokines: An update. Annu. Rev. Immunol. 1997. 15: 675-705.
3. Baggiolini, M., Chemokines and leukocyte traffic. Nature 1998. 392: 565-568.
4. Luster, A. D., Chemokines - Chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 1998. 338: 436-445.
5. Keiner, G. S., Kennedy, J., Bacon, K. B., Kleyensteuber, S., Largaespada, D. A., Jenkins, N. A., Copeland, N. G., Bazan, J. F., Moore, K. W., Schall, T. J. and Zlotnik, A., Lymphotactin: A cytokine that represents a new class of chemokine. Science 1994. 266: 1395-1399.
6. Kennedy, J., Kelner, G. S., Kleyensteuber, S., Schall, T. J., Weiss, M. C., Yssel, H., Schneider, P. V., Cocks, B. G., Bacon, K. B. and Zlotnik, A., Molecular cloning and functional characterization of human lymphotactin. J. Immunol. 1995. 155: 203-209.
7. Pan, Y., Lloyd, C., Zhou, H., Dolich, S., Deeds, J., Gonzalo, J. A., Vath, J., Gosselin, M., Ma, J. Y., Dussault, B., Woolf, E., Alperin, G., Culpepper, J., Gutierrez-Ramos, J. C. and Gearing, D., Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 1997. 387: 611-617.
8. 3C motif. Nature 1997. 385: 640-644.
9. Murphy, P. M., The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 1994. 12: 593-633.
10. Farber, J. M., A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. USA 1990. 87: 5238-5242.
11. Farber, J. M., HuMIG: A new human member of the chemokine family of cytokines. Biochem. Biophys. Res. Commun. 1993. 192: 223-230.
12. Luster, A. D., Unkeless, J. C. and Ravetch, J. V., γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 1985. 315: 672-676.
13. Vanguri, P. and Farber, J. M., Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. J. Biol. Chem. 1990. 265: 15049-15057.
14. Piali, L., Weber, C., LaRosa, G., Mackay, C. R., Springer, T. A., dark-Lewis, I. and Moser, B., The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur. J. Immunol. 1998. 28: 961-972.
15. Issekutz, T. B., Stoltz, J. M. and Meide, P. V. D., Lymphocyte recruitment in delayed-type hypersensitivity. The role of IFN-γ. J. Immunol. 1988. 140: 2989-2993.
16. Watanabe, Y., Kuribayashi, K., Miyatake, S., Nishihara, K., Nakayama, E., Taniyama, T. and Sakata, T., Exogenous expression of mouse Interferon γ cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity. Proc. Natl. Acad. Sci. USA 1989. 86: 9456-9460.
17. Luster, A. D. and Leder, P., IP-10, a -C-X-C-chemokine, elicits a potent thymus-dependent antitumor response in vivo. J. Exp. Med. 1993. 178: 1057-1065.
18. Liao, F., Rabin, R. L., Yannelli, J. R., Koniaris, L. G., Vanguri, P. and Farber, J. M., Human mig chemokine: Biochemical and functional characterization. J. Exp. Med. 1995. 182: 1301-1314.
19. Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., dark-Lewis, I., Baggiolini, M. and Moser, B., Chemokine receptor specific for IP10 and Mig: Structure, function, and expression in activated T-lymphocytes. J. Exp. Med. 1996. 184: 963-969.
20. Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B. and Mackay, C. R., The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 1997. 101: 746-754.
21. Loetscher, P., Uguccioni, M., Bordoli, L., Baggiolini, M., Moser, B., Chizzolini, C. and Dayer, J.-M., CCR5 is characteristic of Th 1 lymphocytes. Nature 1998. 391: 344-345.
22. Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., Sahagan, B. G. and Neote, K., Interferon-inducible T cell chemoattractant (I-TAC): a novel non-Glu-Leu-Arg (ELR) CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 1998. 187: 2009-2021.
23. Moser, B., Schumacher, C., von Tscharner, V., Clark-Lewis, I. and Baggiolini, M., Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils. J. Biol. Chem. 1991. 266: 10666-10671.
24. Kaziro, Y., Itoh, H., Kozasa, T., Nakafuku, M. and Satoh, T., Structure and function of signal-transducing GTP-binding proteins. Annu. Rev. Biochem. 1991. 60: 349-400.
25. Roth, S. J., Carr, M. W. and Springer, T. A., C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. Eur. J. Immunol. 1995. 25: 3482-3488.
26. Loetscher, P., Seitz, M., Baggiolini, M. and Moser, B., Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J. Exp. Med. 1996. 184: 569-577.
27. Luster, A. D., Greenberg, S. M. and Leder, P., The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med. 1995. 182: 219-231.
28. Arenberg, D. A., Polverini, P. J., Kunkel, S. L., Shanafelt, A., Hesselgesser, J., Horuk, R. and Strieter, R. M., The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer. J. Leukoc. Biol. 1997. 62: 554-562.
29. Witt, D. P. and Lander, A. D., Differential binding of chemokines to glycosaminoglycan subpopulations. Curr. Biol. 1994. 4: 394-400.
30. Colditz, I. G., Zwahlen, R. D. and Baggiolini, M., Neutrophil accumulation and plasma leakage induced in vivo by neutrophil-activating peptide-1. J. Leukoc. Biol. 1990. 48: 129-137.
31. Webb, L. M. C., Ehrengruber, M. U., dark-Lewis, I., Baggiolini, M. and Rot, A., Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc. Natl. Acad. Sci. USA 1993. 90: 7158-7162.
32. Wagner, L., Yang, O. O., Garcia-Zepeda, E. A., Ge, Y. M., Kalams, S. A., Walker, B. D., Pasternack, M. S. and Luster, A. D., β-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans. Nature 1998. 391: 908-911.
33. Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A. and Butcher, E. C., Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 1998. 279: 381-384.
34. + progenitors to peripheral blood. J. Exp. Med. 1997. 185: 111-120.
35. D'Apuzzo, M., Rolink, A., Loetscher, M., Hoxie, J. A., Clark-Lewis, I., Melchers, F., Baggiolini, M. and Moser, B., The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. Eur. J. Immunol. 1997. 27: 1788-1793.
36. Legier, D. F., Loetscher, M., Roos, R. S., Clark-Lewis, I., Baggiolini, M. and Moser, B., B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 1998. 187: 655-660.
37. Gunn, M. D., Ngo, V. N., Ansel, K. M., Ekland, E. H., Cyster, J. G. and Williams, L. T., A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998. 391: 799-803.
38. Bleul, C. C., Wu, L. J., Hoxie, J. A., Springer, T. A. and Mackay, C. R., The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 1997. 94: 1925-1930.
39. Wu, L. J., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., Choe, H., Sodroski, J., Newman, W., Koup, R. A. and Mackay, C. R., CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J. Exp. Med. 1997. 185: 1681-1691.
40. Sallusto, F., Mackay, C. R. and Lanzavecchia, A., Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997. 277: 2005-2007.
41. Marchese, A., Heiber, M., Nguyen, T., Heng, H. H. Q., Saldivia, V. R., Cheng, R., Murphy, P. M., Tsui, L. C., Shi, X. M., Gregor, P., George, S. R., O'Dowd, B. F. and Docherty, J. M., Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14 encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 1995. 29: 335-344.
42. Clark-Lewis, I., Moser, B., Walz, A., Baggiolini, M., Scott, G. J. and Aebersold, R., Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2. Biochemistry 1991. 30: 3128-3135.
43. von Tscharner, V., Prod'hom, B., Baggiolini, M. and Reuter, H., Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. Nature 1986. 324: 369-372.
44. Sambrook, J., Fritsch, E. F. and Maniatis, T. (Eds.), Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989.
45. Samson, M., Labbe, O., Mollereau, C., Vassart, G. and Parmentier, M., Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 1996. 35: 3362-3367.