The emergence of selective 5-HT2B antagonists structures, activities and potential therapeutic applications

Mini-Reviews in Medicinal Chemistry

Volumn 4, Issue 3, 2004, Pages 325-330

  Poissonnet, G ^a   Parmentier, J G ^a   Boutin, J A ^a   Goldstein, Solo ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

5 HT2B; Antagonist; Receptor; Review; Serotonin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (1 METHYL 5 INDOLYL) 3 (3 METHYL 5 ISOTHIAZOLYL)UREA; 1 (1 METHYL 5 INDOLYL) 3 (3 PYRIDYL)UREA; 1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; EGIS 7625; LY 23728; LY 266097; LY 272015; MT 500; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE; RS 127445; RS 27354; SB 215505; SDZSER 082; SEROTONIN 2 ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; TRAZODONE; TRYPTOLINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; YOHIMBINE; ZD 6021; LIGAND; SEROTONIN ANTAGONIST;

BINDING AFFINITY; CLINICAL TRIAL; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG EXTRAVASATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DURA MATER; HUMAN; IC 50; IRRITABLE COLON; MEDICAL LITERATURE; MIGRAINE; NONHUMAN; PATENT; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SIDE EFFECT; ANIMAL; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM;

ANIMALS; BINDING, COMPETITIVE; DRUG DESIGN; HUMANS; IRRITABLE BOWEL SYNDROME; LIGANDS; MIGRAINE DISORDERS; MOLECULAR STRUCTURE; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN ANTAGONISTS;

EID: 2342567833     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389557043487312     Document Type: Review

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