Cross-regulation of CD86 by CD80 differentially regulates T helper responses from Mycobacterium tuberculosis secretory antigen-activated dendritic cell subsets

Journal of Leukocyte Biology

Volumn 75, Issue 5, 2004, Pages 874-883

  Balkhi, Mumtaz Yaseen ^a   Latchumanan, Vinoth K ^a   Singh, Balwan ^a   Sharma, Pawan ^a   Natarajan, Krishnamurthy ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

Co stimulation; Cross talk; MTSA; Polarization; Th1 response

Indexed keywords

B7 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 12; MONOCLONAL ANTIBODY; MYCOBACTERIUM ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CELL INTERACTION; CELL POLARITY; COCULTURE; DENDRITIC CELL; FEMALE; HELPER CELL; MOLECULAR INTERACTION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TH1 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; BONE MARROW CELLS; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; FEMALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, HELPER-INDUCER; UP-REGULATION;

ACTINOBACTERIA (CLASS); ANIMALIA; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 2342531103     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1003476     Document Type: Article

References (42)

1. Steinman, R. M. (1999) Dendritic cells. In Fundamental Immunology (W. E. Paul, ed.), Philadelphia, PA, Lippincott-Raven, 547-573.
2. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
3. Reid, S. D., Penna, G., Adorini, L. (2000) The control of T cell responses by dendritic cells subsets. Curr. Opin. Immunol. 12, 114-121.
4. Kalinski, P., Catharien, M. U. H., Weimenga, E. A., Kapsenberg, M. L. (1999) T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of the third signal. Immunol. Today 20, 561-567.
5. Kourilsky, P., Truffa-Bachi, P. (2001) Cytokine fields and the polarization of immune response. Trends Immunol. 22, 502-509.
6. Swallow, M., Wallin, J. J., Shaw, W. (1999) B7h a novel costimulatory homolog of B7.1 and B7.2 is induced by TNF-α. Immunity 11, 423-432.
7. Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U., Guo, J., Horan, T., Shih, G., Zhang, M., Coccia, M. A., Kohno, T., Tafuri-Bladt, A., Brankow, D., Campbell, P., Chang, D., Chiu, L., Dai, T., Duncan, G., Elliott, G. S., Hui, A., McCabe, S. M., Scully, S., Shahinian, A., Shaklee, C. L., Van, G., Mak, T. W., et al. (1999) T-cell costimulation through B7RP-1 and ICOS. Nature 402, 827-832.
8. Ling, V., Wu, P., Finnerty, H. F. (2000) Identification of GL50, a novel B7 like protein that functionally binds to ICOS receptor. J. Immunol. 164, 1653-1657.
9. Freeman, G. J., Gray, G. S., Gimmi, C. D., Lombard, D. B., Zhou, L. J., White, M., Fingeroth, J. D., Gribben, J. G., Nadler, L. M. (1991) Structure, expression and T cell costimulatory activity of the murine homolog of the human B lymphocyte activation antigen B7. J. Exp. Med. 174, 625-631.
10. Azuma, M., Ito, D. H., Yagita, K., Okumara, J. H., Phillips, L. L., Lanier, C., Somoza, C. (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366, 76-79.
11. Freeman, G. J., Gribben, G. J., Bouisiotis, V. A., Ng, J. W., Restivo, V. A., Lombard, L. A., Gray, G. S., Nadler, L. M. (1993) Cloning of B7-2 a CTLA-4 counter receptor that costimulates human T cell proliferation. Science 262, 909-911.
12. Chen, C., Faherty, D. A., Gault, A., Conaughton, S. E., Powers, G. D., Godfrey, D. I., Nabavi, N. (1994) Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes. J. Immunol. 152, 2105-2114.
13. Stack, R. M., Lenchow, D. J., Gray, G. S., Bluestone, J. A., Fitch, J. A. (1994) IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J. Immunol. 152, 5723-5733.
14. Natarajan, K., Sahoo, N. C., Rao, K. V. S. (2001) Signal thresholds and modular synergy during expression of costimulatory molecules in B lymphocytes. J. Immunol. 167, 114-122.
15. Lenchow, D. L., Sperling, A. I., Cooke, M. P., Freeman, G., Rhee, I., Decker, D. C., Gray, G., Nadler, L. M., Goodnow, C. C., Bluestone, J. A. (1994) Differential expression of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J. Immunol. 153, 1990-1997.
16. Freeman, G., Freedman, J. A. S., Segil, J. M., Lee, G., Whitman, J. F., Nadler, L. M. (1989) B7 a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143, 2714-2722.
17. Lenchow, D. J., Su, G. H-T., Zuckerman, L. A., Nabavi, N., Jellis, C. L., Gray, G. S., Miller, J., Bluestone, J. A. (1993) Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 90, 11054-11058.
18. Vijayakrishnan, L., Natarajan, K., Manivel, V., Raisuddin, S., Rao, K. V. S. (2000) B cell responses to a peptide epitope. IX. The kinetics of antigen binding differentially regulates the co-stimulatory capacity of activated B cells. J. Immunol. 164, 5605-5614.
19. Sahoo, N. C., Rao, K. V. S., Natarajan, K. (2002) CD80 expression is induced on activated B cells following stimulation by CD86. Scand. J. Immunol. 55, 577-584.
20. Latchumanan, V. K., Singh, B., Sharma, P., Natarajan, K. (2002) Mycobacterium tuberculosis antigens induce the differentiation of dendritic cells from bone marrow. J. Immunol. 169, 6856-6864.
21. Natarajan, K., Latchumanan, V. K., Singh, B., Singh, S., Sharma, P. (2003) Downregulation of T helper 1 responses to mycobacterial antigens due to maturation of dendritic cells by 10 kDa Mycobacterium tuberculosis secretory antigen. J. Infect. Dis. 187, 914-928.
22. Balkhi, M. Y., Sinha, A., Natarajan, K. (2004) A dominance of CD86, TGF-β and interleukin-10 from Mycobacterium tuberculosis secretory antigen activated dendritic cells regulate T helper 1 responses to mycobacterial antigens. J. Infect. Dis., in press.
23. Maldonado-Lopez, R., Smedt, T. D., Chel, P. M., Godfroid, J., Pajak, B., Heirman, C., Theilemans, K., Leo, O., Urbain, J., Moser, M. (1999) CD8a+ and CD8a- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J. Exp. Med., 189, 587-592.
24. Lenchow, D. J., Walunas, T. L., Bluestone, J. A. (1996) CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258.
25. Krummel, M. F., Allison, J. (1995) CD28 and CTLA-4 deliver opposing signals, which regulate the response of T cells to stimulation. J. Exp. Med. 182, 459-465.
26. Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., Glimcher, L. H. (1995) B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: application to autoimmune disease therapy. Cell 80, 707-718.
27. Freeman, G. J., Boussiotis, V. A., Anumanthan, A., Bernstein, G. M., Ke, X-Y., Rennert, P. D., Gray, G. S., Gribben, G., Nadler, L. M. (1995) B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2, 523-532.
28. Greenwald, R. J., Urban, J. F., Ekkens, M. J., Chen, S., Nguyen, D., Fang, H., Finkelman, F. D., Sharpe, A. H., Gause, W. C. (1999) B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite. J. Immunol. 162, 4133-4139.
29. Wu, Z. Q., Khan, A. Q., Shen, Y., Schartman, J., Peach, R., Lees, A., Mond, J. J., Gause, W. C., Snapper, C. M. (2000) B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae. J. Immunol. 165, 6840-6848.
30. + T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function. J. Immunol. 168, 3786-3792.
31. Sousa, C. R. (2001) Dendritic cells as sensors of infection. Immunity 14, 495-498.
32. De Becker, G., Moulin, V., Tielemans, F., De Mattia, F., Urbain, J., Leo, O., Moser, M. (1998) Regulation of T helper cell differentiation in vivo by soluble and membrane proteins provided by antigen-presenting cells. Eur. J. Immunol. 28, 3161-3171.
33. Willems, F., Marchant, A., Delville, J. P., Gerard, C., Delvaux, A., Velu, T., de Boer, M., Goldman, M. (1994) Interleukin-10 inhibits B7 and intercellular adhesion molecule-I expression on human monocytes. Eur. J. Immunol. 24, 1007-1009.
34. Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., Shevach, E. M. (1993) IL-10 inhibits macrophage costimulatory activity by selectively inhibiting upregulation of B7 expression. J. Immunol. 151, 1224-1234.
35. Najafian, N., Khoury, S. J. (2003) T cell costimulatory pathways: blockade for autoimmunity. Expert Opin. Biol. Ther. 3, 227-236.
36. Brown, J. A., Dorfman, D. M., Ma, F. R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A., Freeman, G. F. (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 170, 1257-1266.
37. Bennett, F., Luxenberg, D., Ling, V., Wang, I. M., Marquette, K., Lowe, D., Khan, N., Veldman, G., Jacobs, K. A., Valge-Archer, V. E., Collins, M., Carreno, B. M. (2003) Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J. Immunol. 170, 711-718.
38. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D. M., Okumura, K., Azuma, M., Yagita, H. (2002) Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169, 5538-5545.
39. Okazaki, T., Iwai, Y., Honjo, T. (2002) New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14, 779-782.
40. Greenwald, R. J., Latchman, Y. E., Sharpe, A. H. (2002) Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 14, 391-396.
41. Lutz, M., Knaus, P. (2002) Integration of the TGF-β pathway into the cellular signalling network. Cell. Signal. 14, 977-988.
42. Borriello, F., Freeman, G. J., Edelhoff, S., Disteche, C. M., Nadler, L. M., Sharpe, A. H. (1994) Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5. J. Immunol. 153, 5038-5048.