Regulation of T helper cell differentiation in vivo by soluble and membrane proteins provided by antigen-presenting cells

European Journal of Immunology

Volumn 28, Issue 10, 1998, Pages 3161-3171

  De Becker, Geneviève ^a   Moulin, Véronique ^a   Tielemans, Françoise ^a   De Mattia, Fabrizio ^a   Urbain, Jacques ^a   Leo, Oberdan ^a   Moser, Muriel ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Dendritic cell; IL 12; IL 6; Macrophage; Th1; Th2

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; HELPER CELL; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD86; CELL DIFFERENTIATION; DENDRITIC CELLS; HEMOCYANIN; INTERLEUKIN-12; INTERLEUKIN-6; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; SOLUBILITY; TH1 CELLS; TH2 CELLS;

EID: 0031708614     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199810)28:10<3161::AID-IMMU3161>3.0.CO;2-Q     Document Type: Article

References (44)

1. Gajewski, T. F., Pinnas, M., Wong, T. and Fitch, F. W., Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 1991. 146: 1750-1758.
2. + T cells. J. Immunol. 1995. 154: 5071-5079.
3. Trinchieri, G., Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 1995. 13: 251-276.
4. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L., Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986. 136: 2348-2357.
5. Madden, K. B., Jr., Urban, J. F., Ziltener, H. J., Schrader, J. W., Finkelman, F. D. and Katona, I. M., Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J. Immunol. 1991. 147: 1387-1391.
6. Mosmann, T. R. and Coffman, R. L., TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989. 7: 145-173.
7. Holaday, B. J., Sadick, M. D., Wang, Z.-E., Reiner, S. L., Heinzel, F. P., Parslow, T. G. and Locksley, R. M., Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cells lines. J. Immunol. 1991. 147: 1653-1658.
8. De Becker, G., Sornasse, T., Nabavi, N., Bazin, H., Tielmans, F., Urbain, J., Leo, O. and Moser, M., Immunoglobulin isotype regulation by antigen-presenting cells in vivo. Eur. J. Immunol. 1994. 24: 1523-1528.
9. Sornasse, T., Flamand, V., De Becker, G., Bazin, H., Tielemans, F., Thielemans, K., Urbain, J., Leo, O. and Moser, M., Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. 1992. 175: 15-21.
10. Lespagnard, L., Mettens, P., De Smedt, T., Bazin, H., Urbain, J., Leo, O. and Moser, M., The immune response induced in vivo by dendritic cells is dependent on B7-1 or B7-2, but the inhibition of both signals does not lead to tolerance. Int. Immunol. 1998. 10: 295-304.
11. Thompson, C. B., Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell 1995. 81: 979-982.
12. Kuchroo, V. K., Prabhu Das, M., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N. and Glimcher, L. H., B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995. 80: 707-718.
13. Lenschow, D. J., Ho, S. C., Sattar, H., Rhee, L., Gray, G., Nabavi, N., Herold, K. C. and Bluestone, J. A., Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 1995. 181: 1145-1155.
14. + T cells. J. Exp. Med. 1997. 185: 461-469.
15. Bliss, J., Van Cleave, V., Murray, K., Wiencis, A., Ketchum, M., Maylor, R., Haire, T., Resmini, C., Abbas, A. K. and Wolf, S. F., IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. J. Immunol. 1996. 156: 887-894.
16. De Becker, G., Moulin, V., Mechelen, M. V., Tielemans, F., Urbain, J., Leo, O. and Moser, M., Dendritic cells and macrophages induce the development of distinct T helper cell populations in vivo. In Ricciardi-Castagnoli, P. (Ed.) Dendritic cells in fundamental and clinical immunology, vol. 3. Plenum Press, New York 1997, pp 369-373.
17. Reis e Sousa, C., Hieny, S., Scharton-Kersten, T., Jankovic, D., Charest, H., Germain, R. N. and Sher, A., In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin-12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 1997. 186: 1819-1829.
18. Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C.-Y., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D. A. and Gately, M. K., IL-12-deficient mice are defective in IFNγ production type 1 cytokines responses. Immunity 1996. 4: 471-481.
19. De Smedt, T., Van Mechelen, M., De Becker, G., Urbain, J., Leo, O. and Moser, M., Effect of interleukin-10 on dendritic cell maturation and function. Eur. J. Immunol. 1997. 27: 1229-1235.
20. + T cell subset with an unrestricted cytokine profile. J. Immunol. 1989. 143: 518-525.
21. Ronchese, F., Hausmann, B. and Gros, G. L., Interferon-γ and interleukin-4-producing T cells can be primed on dendritic cells in vivo and do not require the presence of B cells. Eur. J. Immunol. 1994. 24: 1148-1154.
22. Ranger, A. M., Prabhu Das, M., Kuchroo, V. K. and Glimcher, L. H., B7-2 (CD86) is essential for the development of IL-4-producing T cells. Int. Immunol. 1996. 8: 1549-1560.
23. Freeman, G. J., Boussiotis, V. A., Anumanthan, A., Bernstein, G. M., Ke, X.-Y., Rennert, P. D., Gray, G. S., Gribben, J. G. and Nadler, L. M., B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 1995. 2: 523-532.
24. Tsuyuki, S., Tsuyuki, J., Einsle, K., Kopf, M. and Coyle, A. J., Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J. Exp. Med. 1997. 185: 1671-1679.
25. + T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc. Natl. Acad. Sci. USA 1997. 94: 10838-10843.
26. Szabo, S. J., Dighe, A. S., Gubler, U. and Murphy, K. M., Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997. 185: 817-824.
27. Larsen, C. P., Morris, P. J. and Austyn, J. M., Migration of dendritic leukocytes from cardiac allografts into host spleens. J. Exp. Med. 1990. 171: 307-314.
28. De Smedt, T., Pajak, B., Muraille, E., Lespagnard, L., Heinen, E., De Batselier, P., Urbain, J., Leo, O. and Moser, M., Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 1996. 184: 1413-1424.
29. Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K. S., Sakuta, H., Azuma, M., Yagita, H., Okumura, K., Linsley, P. S., Ikehara, S., Muramatsu, S., Hodes, D. J. and Steinman, R. M., The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 1994. 180: 1849-1860.
30. Moser, M., De Smedt, T., Sornasse, T., Tielemans, F., Chentoufi, a. A., Muraille, E., Mechelen, M. V., Urbain, J. and Leo, O., Glucocorticoids down-regulate dendritic cell function in vitro and in vivo. Eur. J. Immunol. 1995. 25: 2818-2824.
31. Mosmann, T. R. and Sad, S., The expanding universe of T-cell subsets: Th1, Th2 and more, Immunol. Today 1996. 17: 138-146.
32. Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
33. Cumberbatch, M., Dearman, R. J. and Kimber, I., Constitutive and inducible expression of interleukin-6 by Langerhans cells and lymph node dendritic cells. Immunology 1996. 87: 513-518.
34. Riva, S., Nolli, M. L., Lutz, M. B., Citterio, S., Girolomoni, G., Winzler, C. and Ricciardi-Castagnoli, P., Bacteria and bacterial cell wall constituents induce the production of regulatory cytokines in dendritic cell clones. J. Inflamm. 1996. 46: 98-105.
35. Ferrick, D. A., Schrenzel, M. D., Mulvania, T, Hsieh, B., Ferlin, W. G. and Lepper, H., Differential production of IFN-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 1995. 373: 255-257.
36. Razi-Wolf, Z., Galvin, F., Gray, G. and Reiser, H., Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor. Proc. Natl. Acad. Sci. USA 1993. 90: 11182-11186.
37. Hathcock, K. S., Laszlo, G., Dickler, H. B., Bradshaw, J., Linsley, P. and Hodes, R. J., Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 1993. 262: 905-907.
38. Vink, A., Coulie, P., Warnier, G., Renauld, J.-C., Stevens, M., Donckers, D. and Van Snick, J., Mouse plasmacytoma growth in vivo: enhancement by interleukin-6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor. J. Exp. Med. 1990. 172: 997-1000.
39. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M.-P., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 1993. 177: 1199-1204.
40. Crowley, M., Inaba, K. and Steinman, R. M., Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 1990. 172: 383-386.
41. Inaba, K., Metlay, J. P., Crowley, M. T. and Steinman, R. M., Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 1990. 172: 631-640.
42. Flamand, V., Abramowicz, D., Goldman, M., Biernaux, C., Huez, G., Urbain, J., Moser, M. and Leo, O., Anti-CD3 antibodies induce T cells from unprimed animals to secrete IL-4 both in vitro and in vivo. J. Immunol. 1990. 144: 2875-2882.
43. Landegren, U., Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. J. Immunol. Methods 1984. 67: 379-388.
44. Hultner, L., Szots, H., Welle, M., Van Snick, J., Moeller, J. and Dormer, P., Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6. Immunology 1989. 67: 408-413.