Effects of pregnanolone alone and in combination with other positive GABAA modulators on complex behavior in rats

Psychopharmacology

Volumn 173, Issue 1, 2004, Pages 195-202

  Gerak, Lisa R ^a   Stevenson, Michael W ^a   Winsauer, Peter J ^a   Moerschbaecher, Joseph M ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Flunitrazepam; Ketamine; Pentobarbital; Pregnanolone; Rats; Repeated acquisition

Indexed keywords

BENZODIAZEPINE RECEPTOR AFFECTING AGENT; ELTANOLONE; FLUNITRAZEPAM; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTOBARBITAL; STEROID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; ERROR; FOOD; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TASK PERFORMANCE;

ANESTHETICS; ANIMALS; BEHAVIOR, ANIMAL; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; EXCITATORY AMINO ACID ANTAGONISTS; GABA MODULATORS; KETAMINE; MALE; PREGNANOLONE; RATS; RATS, LONG-EVANS; REACTION TIME; RECEPTORS, GABA-A; REINFORCEMENT SCHEDULE;

EID: 2342455687     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1717-2     Document Type: Article

References (33)

1. Arolfo MP, Brioni JD (1991) Diazepam impairs place learning in the Morris water maze. Behav Neural Biol 55:131-136
2. Baron SP, Moerschbaecher JM (1996) Disruption of learning by excitatory amino acid receptor antagonists. Behav Pharmacol 7:573-584
3. Baron SP, Wright D, Wenger GR (1998) Effects of drugs of abuse and scopolamine on memory in rats: delayed spatial alternation and matching to position. Psychopharmacology 137:7-14
4. Beekman M, Ungard JT, Gasior M, Carter RB, Dijkstra D, Goldberg SR, Witkin JM (1998) Reversal of behavioral effects of pentylenetetrazol by the neuroactive steroid ganaxolone. J Pharmacol Exp Ther 284:868-877
5. Bickel WK, Hughes JR, Higgins ST (1990) Human behavioral pharmacology of benzodiazepines: effects of repeated acquisition and performance of response chains. Drug Dev Res 20:53-65
6. Bickel WK, Higgins ST, Hughes JR (1991) The effects of diazepam and triazolam on repeated acquisition and performance of response sequences with an observing response. J Exp Anal Behav 56:217-237
7. Cottrell GA, Lambert JJ, Peters JA (1987) Modulation of GABAA receptor activity by alphaxalone. Br J Pharmacol 90:491-500
8. Desjardins PJ, Moerschbaecher JM, Thompson DM, Thomas JR (1982) Intravenous diazepam in humans: effects on acquisition and performance of response chains. Pharmacol Biochem Behav 17:1055-1059
9. Edgar DM, Seidel WF, Gee KW, Lan NC, Field G, Xia H, Hawkinson JE, Wieland S, Carter RB, Wood PL (1997) CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. J Pharmacol Exp Ther 282:420-429
10. Frye CA, Sturgis JD (1995) Neurosteroids affect spatial/reference, working, and long-term memory of female rats. Neurobiol Learn Mem 64:83-96
11. Gasior M, Carter RB, Witkin JM (1999) Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. Trends Pharmacol Sci 20:107-112
12. Hardman JG, Limbird LE, Gilman AG (eds) (2001) Goodman & Gilman's the pharmacological basis of therapeutics, 10th edn. McGraw-Hill, New York, Chicago, San Francisco, Lisbon, London, Madrid, Mexico City, Milan, New Delhi, San Juan, Seoul, Singapore, Sydney, Toronto
13. Hattori K, Oomura Y, Akaike N (1986) Diazepam action on gamma-aminobutyric acid-activated chloride currents in internally perfused frog sensory neurons. Cell Mol Neurobiol 6:307-323
14. Johansson IM, Birzniece V, Lindblad C, Olsson T, Backstrom T (2002) Allopregnanolone inhibits learning in the Morris water maze. Brain Res 934:125-131
15. Kokate TG, Svensson BE, Rogawski MA (1994) Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation. J Pharmacol Exp Ther 270:1223-1229
16. Kokate TG, Yamaguchi S, Pannell LK, Rajamani U, Carroll DM, Grossman AB, Rogawski MA (1998) Lack of anticonvulsant tolerance to the neuroactive steroid pregnanolone in mice. J Pharmacol Exp Ther 287:553-558
17. Ladurelle N, Eychenne B, Denton D, Blair-West J, Schumacher M, Robel P, Baulieu E (2000) Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse. Brain Res 858:371-379
18. A receptor function. Trends Pharmacol Sci 16:295-303
19. Lambert JJ, Belelli D, Harney SC, Peters JA, Frenguelli BG (2001) Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids. Brain Res Rev 37:68-80
20. Mayo W, Dellu F, Robel P, Cherkaoui J, Le Moal M, Baulieu EE, Simon H (1993) Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat. Brain Res 607:324-328
21. McMahon LR, France CP (2002) Acute and chronic effects of the neuroactive steroid pregnanolone on schedule-controlled responding in rhesus monkeys. Behav Pharmacol 13:545-555
22. McNamara RK, Skelton RW (1993) Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. II. Neuropharmacological specificity. Behav Brain Res 59:193-204
23. McNamara RK, Skelton RW (1997) Tolerance develops to the spatial learning deficit produced by diazepam in rats. Pharmacol Biochem Behav 56:383-389
24. A receptors. Brain Res Rev 29:196-217
25. Mennerick S, Zeng CM, Benz A, Shen W, Izumi Y, Evers AS, Covey DF, Zorumski CF (2001) Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission. Mol Pharmacol 60:732-741
26. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322
27. Reddy DS, Rogawski MA (2000) Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther 295:1241-1248
28. Simmonds MA (1981) Distinction between the effects of barbiturates, benzodiazepines and phenytoin on responses to gamma-aminobutyric acid receptor activation and antagonism by bicuculline and picrotoxin. Br J Pharmacol 73:739-747
29. Thompson DM (1973) Repeated acquisition as a behavioral base line for studying drug effects. J Pharmacol Exp Ther 184:506-514
30. Thompson DM, Winsauer PJ, Mastropaolo J (1987) Effects of phencyclidine, ketamine and MDMA on complex operant behavior in monkeys. Pharmacol Biochem Behav 26:401-405
31. Winsauer PJ, Bixler MA, Mele PC (1995) Differential effects of ionizing radiation on the acquisition and performance of response sequences in rats. Neurotoxicology 16:257-269
32. Winsauer PJ, Bixler MA, Mele PC (1996) Comparison of the effects of typical and atypical anxiolytics on learning in monkeys and rats. J Pharmacol Exp Ther 276:1111-1127
33. 1A receptor agonists disrupt learning and performance in rats. J Pharmacol Exp Ther 288:335-347