Acute and chronic effects of the neuroactive steroid pregnanolone on schedule-controlled responding in rhesus monkeys

Behavioural Pharmacology

Volumn 13, Issue 7, 2002, Pages 545-555

  McMahon, L R ^a   France, Charles P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Dependence; Monkey; Neuroactive steroid; Positive GABAA modulator; Pregnanolone; Schedule controlled behavior; Tolerance; Withdrawal

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; ELTANOLONE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTETRAZOLE; STERALOIDS; STEROID; TRIAZOLAM; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESPONSE; DRUG SENSITIVITY; DRUG TOLERANCE; ELECTROSTIMULATION; FEMALE; FOOD; MALE; NONHUMAN; RHESUS MONKEY; STIMULUS;

EID: 0036855718     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200211000-00004     Document Type: Article

References (39)

1. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993). Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241:237-243.
2. Britton KT, Page M, Baldwin H, Koob GF (1991). Anxiolytic activity of steroid anesthetic alphaxalone. J Pharmacol Exp Ther 258:124-129.
3. Czlonkowska AI, Krzascik P, Sienkiewicz-Jarosz H, Siemiatkowski M, Szyndler J, Maciejak P, et al. (2001). Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures. Eur J Pharmacol 425:121-127.
4. Dews PB (1958). Studies on behavior. IV. Stimulant actions of methamphetamine. J Pharmacol Exp Ther 122:137-147.
5. A receptor-mediated chloride uptake. Brain Res 790:334-338.
6. Engel SR, Purdy RH, Grant KA (2001). Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. J Pharmacol Exp Ther 297:489-495.
7. Gasior M, Carter RB, Goldberg SR, Witkin JM (1997). Anti-convulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam. J Pharmacol Exp Ther 282:543-553.
8. Gasior M, Carter RB, Witkin JM (1999). Neuroactive steroids: Potential therapeutic use in neurological and psychiatric disorders. Trends Pharmacol Sci 20:107-112.
9. Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS (1988). Steroid modulation of the chloride ionophore in rat brain: Structure-activity requirements, regional dependence and mechanism of action. J Pharmacol Exp Ther 246:803-812.
10. Gonzalez JP, McCulloch AJ, Nicholls PJ, Sewell RD, Tekle A (1984). Subacute benzodiazepine treatment: Observations on behavioural tolerance and withdrawal. Alcohol Alcohol 19: 325-332.
11. Griffiths RR, Sannerud CA, Ator NA, Brady JV (1992). Zolpidem behavioral pharmacology in baboons: Self-injection, discrimination, tolerance and withdrawal. J Pharmacol Exp Ther 260:1199-1208.
12. Ho IK, Yamamoto I, Loh HH (1975). A model for the rapid development of dispositional and functional tolerance to barbiturates. Eur J Pharmacol 30:164-171.
13. Jaffe JH, Sharpless SK (1965). The rapid development of physical dependence on barbiturates. J Pharmacol Exp Ther 150:140-145.
14. Kokate TG, Yamaguchi S, Pannell LK, Rajamani U, Carroll DM, Grossman AB, Rogawski MA (1998). Lack of anticonvulsant tolerance to the neuroactive steroid pregnanolone in mice. J Pharmacol Exp Ther 287:553-558.
15. Lamb RJ, Griffiths RR (1993). Behavioral effects of pentobarbital, lorazepam, ethanol and chlorpromazine substitution in pento-barbital-dependent baboons. J Pharmacol Exp Ther 265:47-52.
16. Marshall FH, Stratton SC, Mullings J, Ford E, Worton SP, Oakley NR, Hagan RM (1997). Development of tolerance in mice to the sedative effects of the neuroactive steroid minaxolone following chronic exposure. Pharmacol Biochem Behav 58:1-8.
17. A modulators triazolam and pregnanolone in rhesus monkeys. Psychopharmacology 158:289-296.
18. A modulators on schedule-controlled responding in rhesus monkeys. J Pharmacol Exp Ther 300:1017-1025.
19. A modulators to substitute for a midazolam discriminative stimulus in untreated monkeys does not predict potency to attenuate a flumazenil discriminative stimulus in diazepam treated monkeys. J Pharmacol Exp Ther 298:1227-1235.
20. Moran MH, Goldberg M, Smith SS (1998). Progesterone withdrawal II: Insensitivity to the sedative effects of a benzodiazepine. Brain Res 807:91-100.
21. Moran MH, Smith SS (1998). Progesterone withdrawal I: Pro-convulsant effects. Brain Res 807:84-90.
22. Morgan WW (1990). Abuse liability of barbiturates and other sedative-hypnotics. Adv Alcohol Subst Abuse 9:67-82.
23. National Research Council (1996) Guidelines of the Committee on Care and Use of Laboratory Animal Resources. Publication no. (NIH) 85-23. Department of Health, Education and Welfare National Academy Press, Washington DC.
24. Park-Chung M, Wu FS, Farb DH (1994). 3-alpha-Hydroxy-5-beta-pregnan-20-one sulfate: A negative modulator of the NMDA-induced current in cultured neurons. Mol Pharmacol 46:146-150.
25. Ramanjaneyulu R, Ticku MK (1984). Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. Eur J Pharmacol 98:337-345.
26. Reddy DS, Rogawski MA (2000a). Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. J Pharmacol Exp Ther 294:909-915.
27. Reddy DS, Rogawski MA (2000b). Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther 295:1241-1248.
28. Reddy DS, Rogawski MA (2001). Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Epilepsia 42:337-344.
29. Reddy DS, Kim HY, Rogawski MA (2001). Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. Epilepsia 42:328-336.
30. Rowlett JK, Winger G, Carter RB, Wood PL, Woods JH, Woolverton WL (1999). Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys. Psychopharmacology 145:205-212.
31. Rupprecht R, Holsboer F (1999). Neuroactive steroids: Mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22:410-416.
32. Slifer BL, Balster RL, Woolverton WL (1984). Behavioral dependence produced by continuous phencyclidine infusion in rhesus monkeys. J Pharmacol Exp Ther 230:399-406.
33. Squires RF, Saederup E, Crawley JN, Skolnick P, Paul SM (1984). Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain. Life Sci 35:1439-1444.
34. Tallarida RJ, Murray RB (1987). Manual of Pharmacologic Calculations with Computer Programs. New York: Springer-Verlag.
35. Thompson T, Schuster CR (1964). Morphine self-administration, food-reinforced and avoidance behaviors in rhesus monkeys. Psychopharmacologia 5:87-94.
36. Turner DM, Ransom RW, Yang JSJ, Olsen RW (1989). Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J Pharmacol Exp Ther 248:960-966.
37. Ungard JT, Beekman M, Gasior M, Carter RB, Dijkstra D, Witkin JM (2000). Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148:336-343.
38. Vanover KE, Rosenzweig-Lipson S, Hawkinson JE, Lan NC, Belluzzi JD, Stein L, et al. (2000). Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha-21-dihydroxy-3beta-trifluoro-methyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther 295:337-345.
39. Woods JH, Katz JL, Winger G (1992). Benzodiazepines: Use, abuse, and consequences. Pharmacol Rev 44:151-347.