Full and partial 5-HT(1A) receptor agonists disrupt learning and performance in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 1, 1999, Pages 335-347

  Winsauer, Peter J ^a   Rodriguez, F H ^a   Cha, A E ^a   Moerschbaecher, J M ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 DIPROPYLAMINO 1,3,4,5 TETRAHYDROBENZ[CD]INDOLE 6 CARBOXAMIDE; BUSPIRONE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MIXTURE; LEARNING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

EID: 0032940656     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. 1A receptors. Pharmacol Biochem Behav 57:301-307.
2. Bass EW, Means LW and McMillan BA (1992) Buspirone impairs performance of a three-choice working memory water escape task in rats. Brain Res Bull 28:455-461.
3. Benvenga MJ and Leander JD (1993) Antidepressant-like effect of LY228729 as measured in the rodent forced swim paradigm. Eur J Pharmacol 239:249-252.
4. 1A receptor agonist, impairs performance in a passive avoidance task. Eur J Pharmacol 211:227-234.
5. 1A receptor antagonists. Psychopharmacology 119:47-54.
6. 1A agonist. J Pharmacol Exp Ther 267:58-71.
7. 1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur J Pharmacol 154:339-341.
8. 1A serotonin antagonist. Drug Dev Res 16:335-343.
9. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur J Pharmacol. 211:211-219.
10. Kenakin, T (1993) Competitive antagonism, in Pharmacologic Analysis of Drug-Receptor Interaction (Kenakin T ed) pp 278-322, Raven Press, New York.
11. 125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain: In vitro binding and autoradiographic studies. J Pharmacol Exp Ther 272:429-437
12. 1A receptor antagonist: p-MPPI. Life Sci 55:1459-1462.
13. McNaughton N and Morris RGM (1992) Buspirone produces a dose-related impairment of spatial navigation. Pharmacol Biochem Behav 43:167-171.
14. 1A agonists. Mol Pharmacol 37:231-237.
15. 1 recognition site. Eur J Pharmacol 90:151-153.
16. 1A antagonists. J Pharmacol Exp Ther 268:337-352.
17. Przegaliński E, Ismaiel AM, Chojnacka-Wójcik E, Budziszewska B, Tatarczyńska E and Blaszczynska E (1990) The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(di-n-propylamino)-tetralin, is antagonized by NAN-190 in the rat. Neuropharmacology 29:521-526.
18. Rowan MJ, Cullen WK and Moulton B (1990) Buspirone impairment of performance of passive avoidance and spatial learning tasks in the rat. Psychopharmacology 100:393-398.
19. 1A receptors. Brain Res 532:191-196.
20. Stanhope KJ, McLenachan AP and Dourish CT (1995) Dissociation between cognitive and motor/motivational deficits in the delayed matching to position test: Effects of scopolamine, 8-OH-DPAT and EAA antagonists. Psychopharmacology 122:268-280.
21. Taylor DC (1988) Buspirone, a new approach to the treatment of anxiety. FASEB J 2:2445-2452.
22. 1A receptor activation in vivo. Life Sci 56:163-168.
23. Thompson DM (1973) Repeated-acquisition as a behavioral base line for studying drug effects. J Pharmacol Exp Ther 184:506-514.
24. 1A receptor-related anxiolytics. Trends Pharmacol Sci 8:432-437.
25. Winsauer PJ, Bixler MA and Mele PC (1996) Comparison of the effects of typical and atypical anxiolytics on learning in monkeys and rats. J Pharmacol Exp Ther 276:1111-1127.
26. 1A receptors in memory. Pharmacol Biochem Behav 27: 625-628.
27. Witkin JM and Barrett JE (1986) Interaction of buspirone and dopaminergic agents on punished behavior in pigeons. Pharmacol Biochem Behav 24:751-756.