Mesenchymal stem cells in autoimmune disease

Stem Cells and Development

Volumn 13, Issue 5, 2004, Pages 463-472

  El Badri, Nagwa S ^a   Maheshwari, Akhil ^b   Sanberg, Paul R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA;

ADIPOSE TISSUE; AUTOIMMUNE DISEASE; BONE MARROW TRANSPLANTATION; BRAIN ISCHEMIA; CARTILAGE; CYTOKINE PRODUCTION; CYTOLOGY; CYTOTOXICITY; GENETIC MANIPULATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; JUVENILE RHEUMATOID ARTHRITIS; MESENCHYME CELL; MORBIDITY; MORTALITY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; OSTEOBLAST; PALLIATIVE THERAPY; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; STEM CELL; STEM CELL TRANSPLANTATION; STROMA CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; TENDON; TISSUE REPAIR;

ADIPOSE TISSUE; ANIMALS; AUTOIMMUNE DISEASES; CARTILAGE; CELL LINEAGE; CHEMOKINES, CXC; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-8; LUPUS; MESENCHYMAL STEM CELLS; MODELS, BIOLOGICAL; NERVOUS SYSTEM DISEASES; STEM CELL TRANSPLANTATION; STEM CELLS; STROMAL CELLS;

EID: 8144230419     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2004.13.463     Document Type: Review

References (109)

1. Copelan EA and EA McGuire. (1995). The biology and treatment of acute lymphoblastic leukemia in adults. Blood 85:1151-1168.
2. Fefer A, MA Cheever, ED Thomas, C Boyd, R Ramberg, H Glucksberg, CD Buckner and R Storb. (1997). Disappearence of Ph(1)-positive cells in four patients with chronic granulocytic leukemia after chemotherapy, irradiation, and marrow transplantation from an identical twin. N Engl J Med 300:333-337.
3. MacLennan IC, C Chapman, J Dunn and K Kelly. (1992). Combined chemotherapy with ABCM versus melphalan for treatment of myelomatosis. The Medical Research Council Working Party for Leukemia in Adults. Lancet 25:200-205.
4. Bierman PJ, RG Bagin, S Jagganath, JM Vose, G Spitzer, A Kessinger, KA Dicke and JO Armitage. (1993). High dose chemotherapy followed by autologous hematopoietic rescue in Hodgkin's disease: long term follow up in 128 patients. Ann Oncol 4:767.
5. Good RA and T Verjee. (2001). Historical and current perspectives on bone marrow transplantation for prevention and treatment of immunodeficiencies and autoimmunities. Biol Blood Marrow Transplant 7:123-135.
6. Krivit W, C Peters and EG Shapiro. (1999). Bone marrow transplantation as effective treatment of central nervous system disease in globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy, mannosidosis, fucosidosis, aspartylglucosaminuria, Hurler, Maroteaux-Lamy, and Sly syndromes, and Gaucher disease type III. Curr Opin Neurol 12:167-176.
7. Ikehara S. (2001). Treatment of autoimmune diseases by hematopoietic stem cell transplantation. Exp Hematol 29:661-669.
8. Baden L and RH Rubin. (2004). Infection in hematopoietic stem cell transplant recipients. In: Stem Cell Transplantation for Hematologic Malignancies. RA Soiffer, ed. Humana Press Inc., Totowa, NJ, pp. 237-258.
9. Boeckh M and KA Marr. Infection in hematopoietic stem cell transplantation. (2002). In: Clinical Approach to Infection in the Compromised Host, 4th ed. RH Rubin and LS Young, eds. Kluwer Academic/Plenum, New York, pp. 527-571.
10. Dupont B, RJ Oreilly, MS Pollack and RA Good. (1980). Histocompatibility testing for clinical bone marrow transplantation and prospects for identification of donors other than HLA genotypically identical siblings. Haematol Blood Transfus 25:121-134.
11. Ferrara, JL, R Levy and NJ Chao. (1999). Pathophysiologic mechanisms of acute graft versus host disease. Biol Blood Marrow Transplant 5:347-356.
12. Parkman, R. (1998). Chronic graft-versus-host disease. Curr Opin Hematol 5:22-25.
13. Mahmoud H, O Fahmy, A Kamel, M Kamel, A El-Haddad and D El-Kadi. (1999). Peripheral blood versus bone marrow as a source for allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 5:28-35.
14. Broxmeyer HE, GW Douglas, G Hangoc, S Cooper, J Bard, D English, M Arny, L Thomas and EA Boyse. (1989). Human umbulical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad USA. 86:3828-3832.
15. NS El-Badri, BY Wang, Cherry and RA Good. (1998). Osteoblasts promote engraftment of allogeneic hematopoietic stem cells. Exp Hematol 26:110-116.
16. Jacquet EG, CL Schanie, I Fugier-Vivier, SS Willer and ST Ildstad. (2003). Facilitating cells as a venue to establish mixed chimerism and tolerance. Pediatr Transplant 7:348-357.
17. Kaufman CL, YL Colson, SM Wren, SL Watkins, RL Simmons and ST Ildstad. (1994). Phenotypic characterization of a novel bone-marrow derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood. 84:2436-2446.
18. Martin PJ. (1993). Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans. J Exp Med 178:703-712.
19. - cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 11:579-590.
20. Ikehara S. (2001). Successful allogeneic bone marrow transplantation. Crucial roles of stromal cells in prevention of graft rejection. Acta Haematol 105:172-178.
21. Charbord P. (2004). Stromal support of hematopoiesis. In: Stem Cells Handbook. S Sell, ed. Humana Press Inc., Totowa NJ, pp. 143-154.
22. Fan TX, H Hisha, TN Jin, CZ Yu, ZX Lian, SB Guo, YZ Cui, B Feng, GX Yang, Q Li and S Ikehara. (2001). Successful allogeneic bone marrow transplantation (BMT) by injection of bone marrow cells via portal vein: stromal cells as BMT-facilitating cells. Stem Cells 19:144-150.
23. Simmons PJ, S Gronthos, A Zannettino, S Ohta and S Graves. (1994). Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis. Progr Clin Biol Res 389:271-280.
24. Madlambayan GJ, I Rogers, RF Casper and PW Zandstra. (2001). Controlling culture dynamics for the expansion of hematopoietic stem cells. J Hematother Stem Cell Res 10:481-492.
25. Miller CL and CJ Eaves. (1997). Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci USA 94:13648-13653.
26. Bhatia M, D Bonnet, U Kapp, JC Wang, B Murdoch and JE Dick. (1997). Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 186:619-624.
27. Hogge DE, PM Lansdorp, D Reid, B Gerhard and CJ Eaves. (1996). Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-2, and granulocyte colony-stimulating factor. Blood 88:3765-3773.
28. Sutherland HJ, CJ Eaves, AC Eaves, W Dragowska and PM Lansdorp. (1989). Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74:1563-1570.
29. Sutherland HJ, PM Lansdorp, DH Henkelman, AC Eaves and CJ Eaves. (1990). Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci USA 87:3584-3588.
30. Craddock C. (2000). Hematopoietic stem cell transplantation: recent progress and future promise. Lancet Oncol 1:227-234.
31. Erices AA, CI Allers, PA Gonget, CV Rojas and JJ Minguell. (2003). Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion. Cell Transplant 12:555-561.
32. Pittenger MF, JD Mosca JD and KR McIntosh. (2000). Human mesenchymal stem cells: progenitor cells for cartilage, bone, fat and stroma. Curr Top Microbiol Immunol 251:3-11.
33. Owen M. (1988). Marrow stromal cells. J Cell Sci 10:63-76.
34. Caplan AI. Mesenchymal stem cells. (1991). J. Orthop. Res. 9:641-650.
35. Prockop DJ. (1997). Marrow stromal cells as stem cells for hematopoietic tissue. Science 276:71-74.
36. Ryes M, T Lund, T Lenvic, D Aduiar, L Koodie and CM Verfaillie. (2001). Purification and ex vivo expansion of human postnatal human marrow mesodermal progenitor cells. Blood 98:2615-2625.
37. Azizi, S A, D Stokes. BJ Augelli, C DiGirolamo and DJ Prockop. (1998). Engraftment and migration of bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocytes grafts. Proc Natl Acad Sci USA 95:3908-3913.
38. Oh SH, M Miyazaki, H Kouchi, Y Inoue, M Sakaguchi, T Tsuji, N Shima, K Higashio and M Namba. (2000). Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocytes lineage in vitro. Biochem Biophys Res Commun 279:500-504.
39. Cusella-De Angelis G, M Coletta, E Paolucci, A Stornaiuolo, G Cossu and F Mavilio. (1998). Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279:1528-1530.
40. Jiang Y, B Vaessen, T Lenvik, M Blackstad, M Reyes and CM Verfaillie. (2002). Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 30:896-904.
41. + marrow cell population is multipotential. Cell Tiss Org 170:73-82.
42. Craddock C. (2000). Hematopoietic stem cell transplantation: recent progress and future promise. Lancet Oncol 1:227-234.
43. Ho VY and RJ Soiffer. (2001). The history and future of T cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplanttaion. Blood 98:3192-3204.
44. Kolb HJ, J Mittermuller, C Clemm, E Holler, G Ledderose, G Brehm, M Heim, and W Wilmanns. (1990). Donor leukocyte transfusion for treatment of recurrent chronic myelogenous leukemia in marro wtransplant patients. Blood 76:2462-2465.
45. Mosca JD, JK Hendricks, D Buyaner, J Davis-Sproul, LC Chuang, MK Majumdar, R Chopra, F Barry, M Murphy, MA Thiede, U Junker, RJ Rigg, SP Forestell, E Bohnlein, R Storb and BM Sandmaier. (2000). Mesenchymal stem cells as vehicles for gene delivery. Clin Orthop 379 (Suppl):S71-S90.
46. Li Y, H Hisha, M Inaba, Z Lian, C Yu, M Kawamura, Y Yamamoto, N Nishio, J Toki, H Fan and S Ikehara. (2000). Evidence for migration of donor bone marrow stromal cells into recipient thymus after bone marrow transplantation plus bone grafts: A role of stromal cells in positive selection. Exp Hematol 28:950-960.
47. Suniara RK, EJ Jenkinson and JJ Owen. (2000). An essential role for thymic mesenchyme in early T cell development. J Exp Med 191:1051-1056.
48. El-Badri NS and RA Good. (1994). Induction of immunological tolerance in full major and multiminor histocompatibility-disparate mice using a mixed bone marrow transplantation model. Proc Soc Exp Biol Med 205:67-74.
49. Onoe K, G Fernandes and RA Good. (1980). Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice. J Exp Med 151:115-132.
50. Ikehara S. (2002). Bone marrow transplantation: a new strategy for intractable diseases. Drugs Today 38:103-111.
51. Di Nicola M, C Carlo-Stella, M Magni, M Milanesi, PD Longoni, P Matteucci, S Grisanti and AM Gianni. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838-3843.
52. Bartholomew A, C Sturgeon, M Siatskas, K Ferrer, K McIntosh, S Patil, W Hardy, S Devine, D Ucker, R Deans, A Moseley and R Hoffman. (2002). Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42-48.
53. Krampera M, S Glennie, J Dyson, D Scott. R Laylor, E Simpson and F. Dazzi. (2003). Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 101:3722-3729.
54. Meloni G, S Capria, M Vignetti, F Mandelli and V Modena. (1997). Blast crisis of chronic myelogenous leukemia in long-lasting systemic lupus erythematosus: regression of both diseases after autologous bone marrow transplantation. Blood 89:4659.
55. Ikehara S. (2001). Treatment of autoimmune diseases by hematopoietic stem cell transplantation. Exp Hematol 29:661-669.
56. Snowden JA, P Kearney, A Kearney, HM Cooley, A Grigg, P Jacobs, J Bergman, PM Brooks and JC Biggs. (1998). Long-term outcome of autoimmune disease following allogeneic bone marrow transplantation. Arthritis Rheum 41:453-459.
57. Wulffraat N, A van Royen, M Bierings, J Vossen and W Kuis. (1999). Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis. Lancet 353:550-553.
58. Burt RK, AE Traynor, B Cohen, KH Karlin, FA Davis, D Stefoski, C Terry, L Lobeck, EJ Russell, C Goolsby, S Rosen, LI Gordon, C Keever-Taylor, M Brush, M Fishman and WH Burns. (1998). T cell-depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report on the first three patients. Bone Marrow Transplant 21:537-541.
59. Euler HH, AM Marmont, A Bacigalupo, S Fastenrath, P Dreger, M Hoffknecht, AR Zander, B Schalke, U Hahn, R Haas and N Schmitz. (1996). Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood 88:3621-3625.
60. NakamuraT, S Ikehara, RA Good, S Inoue, A Sekita, F Furukaawa, H Tanaka, O Maung and Y Hamashima. (1985). Abnormal stem cells in autoimmune-prone mice are responsible for premature thymic involution. Thymus 7:15.
61. Cherry, RW Engelman, B-Y Wang, K Kinjoh, NS El-Badri and RA Good. (1985). RA Calorie restriction delays the crescentic glomerulonephritis of SCG/Kj mice. Proc Soc Exp Biol Med 218:223-228.
62. Jones OY, A Steele, JM Jones, Y Marikar, Y Chang, A Feliz, RA Cahill and RA Good. (2004). Nonmyeloablative bone marrow transplantation of BXSB lupus mice using fully matched allogeneic donor cells from green fluorescent protein transgenic mice. J Immunol 172:5415-5419.
63. Wang B-Y, Y Yamamoto, NS El-Badri and RA Good. (1999). Effective treatment of autoimmune disease and progressive renal disease by mixed bone-marrow transplantation that establishes a stable mixed chimerism in BXSB recipient mice. Proc Natl Acad Sci USA 96:3012-3016.
64. Mizutani H, RW Engelman, Y Kurate, S Ikehara and RA Good. (1993). Prevention and induction of occlusive coronary vascular disease in autoimmune (W/B) F1 mice by haploidentical bone marrow transplantation: possible role for anticardiolipin autoantibodies. Blood 82:3091-3098.
65. El-Badri NS, B-Y Wang, A Steele, Cherry, Y Marikar, K Mizobe and RA Good. (2000). Successful prevention of autoimmune disease by transplantation of adequate number of fully allogeneic hematopoietic stem cells. Transplantation 70:870-877.
66. Good RA, B-Y Wang, NS El-Badri NS, A Steele and T Verjee. (2002). Mixed bone marrow or mixed stem cell transplantation for prevention or treatment of lupus-like diseases in mice. Exp Nephrol 10:408-420.
67. Wang B-Y, Y Yamamoto, NS El-Badri and RA Good. (1999). Effective treatment of autoimmune disease and progressive renal disease by mixed bone-marrow transplantation that establishes a stable mixed chimerism in BXSB recipient mice. Proc Natl Acad Sci USA 96:3012-3016.
68. Kushida T, M Inaba, H Hisha, N Ichioka, T Esumi, R Ogawa, H Iida and S Ikehara. (2001). Crucial role of donor-derived stromal cells in successful treatment for intractable autoimmune diseases in MRL/lpr mice by BMT via portal vein. Stem Cells 19:226-235.
69. Kushida T, M Inaba, K Takeuchi, K Sugiura, R Ogawa and S Ikehara. (2000). Treatment of intractable autoimmune diseases in MRL/lpr mice using a new strategy for allogeneic bone marrow transplantation. Blood 9:1862-1868.
70. Hisha H, T Nishino, M Kawamura, S Adachi and S Ikehara. (1995). Successful bone marrow transplantation by bone grafts in chimeric-resistant combination. Exp Hematol 23:347-352.
71. Bargetzi MJ, A Schonenberger, A Tichelli, R Fried, G Cathomas, E Signer, B Speck and A Gratwohl. (1997). Celiac disease transmitted by allogeneic non-T cell-depleted bone marrow transplantation. Bone Marrow Transplant 20:607-609.
72. Lampeter EF, SR McCann and H Kolb. (1998). Transfer of diabetes type 1 by bone-marrow transplantation. Lancet 351:568-569.
73. Nakano T, H Kodama and T Honjo. (1994). Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265:1098-1101.
74. + cells. J Cell Physiol 189:45-53.
75. Charbord P, E Tamayo, S Saeland, V Duvert, J Poulet, AM Gown and P Herve. (1991). GM-CSF in human long term bone marrow culture: endogenous production in the adherent layer and effect of exogenous GM-CSF on granulomonopoiesis. Blood 78:1230-1236.
76. Sutherland H J, CJ Eaves, PM Lansdrop, JD Thacker and DE Hogge. (1991). Differential regulation of primitive human hematopoietic cells in long-term cultures maintained on genetically engineered murine stromal cells. Blood 78:666-672.
77. Chiu CP, C Moulds, RL Coffman, D Rennick and F Lee. (1988). Multiple histological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci USA 85:7099-7103.
78. Paul SR, F Bennett, JA Calvetti, K Kelleher, CR Wood, RM O'Hara Jr, AC Leary, B Sibley, SC Clark, DA Williams et al. (1990). Molecular cloning of a cDnA encoding interleukin 11, a stromal cell derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA. 87:7512-7516.
79. Williams DE, J Eisenman, A Baird, C Rauch, K Van Ness, CJ March, LS Park, U Martin, DY Mochizuki, HS Boswell, GS Burgess, D Cosman and SD Lyman. (1990). Identification of a ligand for c-kit proto-oncogene. Cell 63:167-174.
80. Lisovsky M, SE Braun, Y Ge, H Takahira, L Lu, VG Savchenko, SD Lyman and HE Broxmeyer. (1996). Flt3-ligand production by human bone marrow stromal cells. Leukemia. 10:1012-1018.
81. Nagasawa T, H Kikutani and T Kishimoto. (1994). Molecular cloning and structure of pre B cell growth-stimulating factor. Proc Natl Acad Sci USA 91:2305-2309.
82. Bleul CC, RC Fuhlbrigge, JM Casanovas, A Aiuti and TA Springer. (1996). A highly efficacious lymphocyte chemoattractant, stromal cell derived factor 1 (SDF-1). J Exp Med 184:1101-1109.
83. Mukaida N. (2000). Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. Int J Hematol 72:391-398.
84. Holcombe RF, BA Baethge, RE Wolf, KW Betzing, RM Stewart, VC Hall and M Fukuda. (1994). Correlation of serum interleukin-8 and cell surface lysosome-associated membrane protein expression with clinical disease activity in systemic lupus erythematosus. Lupus 3:97-102.
85. Wada T, H Yokoyama, N Tomosugi, Y Hisada, S Ohta, T Naito, K Kobayashi, N Mukaida and K Matsushima. (1994). Detection of urinary interleukin-8 in glomerular diseases. Kidney Int 46:455-460.
86. Yokoyama H, T Wada, K Furuichi et al. (1998). Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy. J Leukoc Biol 63:493-499.
87. Rovin BH, L Lu and X Zhang. (2002). A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis. Kidney Int 62:261-265.
88. Furuse S, H Fujii, Y Kaburagi, M Fujimoto, M Hasegawa, K Takehara and S Sato. (2003). Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosis. J Rheumatol 30:1524-1528.
89. Mansergh FC, MA Wride and DE Rancourt. (2000). Neurons from stem cells: implications for understanding nervous system development and repair. Biochem Cell Biol 78:613-628.
90. Deng W, M Obrocka, I Fische and DJ Prockop. (2001). In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun 282:148-152.
91. Woodbury D, EJ Schwarz, DJ Prockop and IB Black. (2000). Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364-370.
92. Sanchez-Ramos J, S Song, F Cardozo-Pelaez, C Hazzi, T Stedeford, A Willing, TB Freeman, S Saporta, W Janssen, N Patel, DR Cooper and PR Sanberg. (2000). Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 164:247-256.
93. Wu S, Y Suzuki, Y Ejiri, T Noda, H Bai, M Kitada, K Kataoka, M Ohta, H Chou and C Ide. (2003). Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res 72:343-351.
94. Eglitis MA, D Dawson, KW Park and MM Mouradian. (1999). Targeting of marrow-derived astrocytes to the ischemic brain. Neuroreport 26:1289-1292.
95. Flugel A, M Bradl, GW Kreutzberg and MB Graeber. (2001). Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J Neurosci Res 66:74-82.
96. Chopp M, XH Zhang, Y Li, L Wang, J Chen, D Lu, M Lu and M Rosenblum. (2000). Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport 11:3001-3005.
97. Lu D, Y Li, L Wang, J Chen, A Mahmood and M Chopp. (2001). Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma 18:813-819.
98. Hofstetter CP, EJ Schwarz, D Hess, J. Widenfalk, A El Manira, DJ Prockop and L Olson. (2002). Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 99:2199-2204.
99. Irons H, JG Lind, CG Wakade, G Yu, M Hadman, J Carroll, DC Hess and CV Borlongant. (2004). Intracerebral xenotransplantation of GFP mouse bone marrow stromal cells in intact and stroke rat brain: graft survival and immunologic response. Cell Transplant 13:283-294.
100. Jiang Y, D Henderson, M Blackstad, A Chen, RF Miller and CM Verfaillie. (2003). Neuroectodermal differentiation from mouse multipotent adult progenitor cells. Proc Natl Acad Sci USA 100 (Suppl 1):11854-11860.
101. Frank MH and MH Sayegh. (2004). Immunomodulatory functions of mesenchymal stem cells. Lancet 1:363:1411-1412.
102. Le Blanc K, I Rasmusson, B Sundberg, C Gotherstrom, M Hassan, M Uzunel and PO Ringden. (2004). Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 63:1439-1441.
103. Cahill RA, MR Klemprer, A Steele, NS El-Badri and RA Good. (2004). Replacement of recipient stromal/mesenchymal cells (SC/MSCs) after bone marrow transplantation using bone fragments and cultured osteoblast-like cells. (Submitted).
104. El-Badri NS. (2000). The role of osteoblasts in experimental and clinical transplantation. Graft 3:307-310.
105. Lee ST, JH Jang, JW Cheong, JS Kim, HY Maemg, JS Hahn, YW Ko and YH Min. (2002). Treatment of high-risk acute myelogenous leukemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted hematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leukocyte antigen haplotype. Br J Haematol 118:1128-1131.
106. Chamberlain JR, U Schwarze, PR Wang, RK Hirata, KD Hankenson, JM Pace, RA Underwood, KM Song, M Sussman, PH Byers and DW Russell. (2004). Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science 303:1198-1201.
107. Prockop DJ. (2004). Targeting gene therapy for osteogenesis imperfecta. N Engl J Med 350:2302-2304.
108. Staba SL, ML Escolar, M Poe, Y Kim, PL Martin, P Szabolcs, J Allison-Thacker, S Wood, DA Wenger, P Rubinstein, JJ Hopwood, J Krivit and W Kurtzberg. (2004). Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Engl J Med 6:1960-1969.
109. El-Badri NS, C Pascual and Y Chang. (2004). Bone marrow stem cell engraftment in systemic lupus murine model. ASNTR 11th Annual Conference, May 6-9, 2004. Clearwater Beach, FL.