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Volumn 7, Issue 2, 2005, Pages 92-102

Mechanistic features of recombination in HIV

Author keywords

Genetic variability; HIV; Molecular mechanism; Recombination

Indexed keywords

GENOMIC RNA; VIRUS RNA;

EID: 23144449384     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (43)

References (111)
  • 1
    • 0034723385 scopus 로고    scopus 로고
    • AIDS as a zoonosis: Scientific and public health implications
    • Hahn B, Shaw G, De Cock K, Sharp P. AIDS as a zoonosis: scientific and public health implications. Science 2000;287:607-14.
    • (2000) Science , vol.287 , pp. 607-614
    • Hahn, B.1    Shaw, G.2    De Cock, K.3    Sharp, P.4
  • 2
    • 0033521911 scopus 로고    scopus 로고
    • Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes
    • Gao F, Bailes E, Robertson D, et al. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 1999;397:436-41.
    • (1999) Nature , vol.397 , pp. 436-441
    • Gao, F.1    Bailes, E.2    Robertson, D.3
  • 3
    • 0001325020 scopus 로고    scopus 로고
    • HIV-1 Nomenclature Proposal
    • Kuiken C, Foley B, Hahn B, et al. (eds.). Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM
    • Robertson D, Anderson J, Bradac J, et al. HIV-1 Nomenclature Proposal. In Human Retroviruses and AIDS 1999. Kuiken C, Foley B, Hahn B, et al. (eds.). Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 1999; 492-505.
    • (1999) Human Retroviruses and AIDS 1999 , pp. 492-505
    • Robertson, D.1    Anderson, J.2    Bradac, J.3
  • 5
    • 0036319711 scopus 로고    scopus 로고
    • Molecular epidemiology of HIV-1 genetic forms and its significance for vaccine development and therapy
    • Thomson M, Perez-Alvarez L, Najera R. Molecular epidemiology of HIV-1 genetic forms and its significance for vaccine development and therapy. Lancet Infect Dis 2002;2:461-71.
    • (2002) Lancet Infect. Dis. , vol.2 , pp. 461-471
    • Thomson, M.1    Perez-Alvarez, L.2    Najera, R.3
  • 6
    • 0033755804 scopus 로고    scopus 로고
    • Unprecedented degree of HIV type 1 (HIV-1) group M genetic diversity in the Democratic Republic of Congo suggests that the HIV-1 pandemic originated in Central Africa
    • Vidal N, Peeters M, Mulanga-Kabeya C, et al. Unprecedented degree of HIV type 1 (HIV-1) group M genetic diversity in the Democratic Republic of Congo suggests that the HIV-1 pandemic originated in Central Africa. J Virol 2000;74:10498-507.
    • (2000) J. Virol. , vol.74 , pp. 10498-10507
    • Vidal, N.1    Peeters, M.2    Mulanga-Kabeya, C.3
  • 7
    • 1642465048 scopus 로고    scopus 로고
    • Genetic diversity of HIV in Africa: Impact on diagnosis, treatment, vaccine development and trials
    • Peeters M, Toure-Kane C, Nkengasong J. Genetic diversity of HIV in Africa: impact on diagnosis, treatment, vaccine development and trials. Aids 2003;17:2547-60.
    • (2003) Aids , vol.17 , pp. 2547-2560
    • Peeters, M.1    Toure-Kane, C.2    Nkengasong, J.3
  • 8
    • 8044230048 scopus 로고    scopus 로고
    • Geographical distribution of HIV-1 group O viruses in Africa
    • Peeters M, Gueye A, Mboup S, et al. Geographical distribution of HIV-1 group O viruses in Africa. Aids 1997;11:493-8.
    • (1997) Aids , vol.11 , pp. 493-498
    • Peeters, M.1    Gueye, A.2    Mboup, S.3
  • 9
    • 0033738866 scopus 로고    scopus 로고
    • HIV-1 group N among HIV-1-seropositive individuals in Cameroon
    • Ayouba A, Souquieres S, Njinku B, et al. HIV-1 group N among HIV-1-seropositive individuals in Cameroon. Aids 2000;14:2623-5.
    • (2000) Aids , vol.14 , pp. 2623-2625
    • Ayouba, A.1    Souquieres, S.2    Njinku, B.3
  • 10
    • 3042645081 scopus 로고    scopus 로고
    • Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification
    • Damond F, Worobey M, Campa P, et al. Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification. AIDS Res Hum Retroviruses 2004;20:666-72.
    • (2004) AIDS Res. Hum. Retroviruses , vol.20 , pp. 666-672
    • Damond, F.1    Worobey, M.2    Campa, P.3
  • 12
    • 33544463327 scopus 로고    scopus 로고
    • HIV Sequence Database
    • The Circulating Recombinant Forms (CRFs). Los Alamos National Laboratory. (last accessed, March)
    • The Circulating Recombinant Forms (CRFs). Los Alamos National Laboratory. HIV Sequence Database. (last accessed, March 2005). http://hiv-web.lanl.gov/content/hiv-db/CRFs/CRFs.html
    • (2005)
  • 14
    • 0032787419 scopus 로고    scopus 로고
    • HIV type 1 intergroup (M/O) recombination in Cameroon
    • Takehisa J, Zekeng L, Ido E, et al. HIV type 1 intergroup (M/O) recombination in Cameroon. J Virol 1999;73:6810-20.
    • (1999) J. Virol. , vol.73 , pp. 6810-6820
    • Takehisa, J.1    Zekeng, L.2    Ido, E.3
  • 15
    • 0032865615 scopus 로고    scopus 로고
    • Characterization of a highly replicative intergroup M/O HIV type 1 recombinant isolated from a Cameroonian patient
    • Peeters M, Liegeois F, Torimiro N, et al. Characterization of a highly replicative intergroup M/O HIV type 1 recombinant isolated from a Cameroonian patient. J Virol 1999;73:7368-75.
    • (1999) J. Virol. , vol.73 , pp. 7368-7375
    • Peeters, M.1    Liegeois, F.2    Torimiro, N.3
  • 16
    • 0036199914 scopus 로고    scopus 로고
    • A coalescent-based method for detecting and estimating recombination from gene sequences
    • McVean G, Awadalla P, Fearnhead P. A coalescent-based method for detecting and estimating recombination from gene sequences. Genetics 2002;160:1231-41.
    • (2002) Genetics , vol.160 , pp. 1231-1241
    • McVean, G.1    Awadalla, P.2    Fearnhead, P.3
  • 17
    • 0015165266 scopus 로고
    • Genetically stable reassortment of markers during mixed infection with avian tumor viruses
    • Vogt P. Genetically stable reassortment of markers during mixed infection with avian tumor viruses. Virology 1971;46:947-52.
    • (1971) Virology , vol.46 , pp. 947-952
    • Vogt, P.1
  • 18
    • 0025095253 scopus 로고
    • Genetic consequences of packaging two RNA genomes in one retroviral particle: Pseudodiploidy and high rate of genetic recombination
    • Hu W, Temin H. Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination. Proc Natl Acad Sci USA 1990: 87:1556-60.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1556-1560
    • Hu, W.1    Temin, H.2
  • 20
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho D, Neumann A, Perelson A, Chen W, Leonard J, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.1    Neumann, A.2    Perelson, A.3    Chen, W.4    Leonard, J.5    Markowitz, M.6
  • 21
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • Preston B, Poiesz B, Loeb L. Fidelity of HIV-1 reverse transcriptase. Science 1988;242:1168-71.
    • (1988) Science , vol.242 , pp. 1168-1171
    • Preston, B.1    Poiesz, B.2    Loeb, L.3
  • 22
    • 0025635705 scopus 로고
    • Retroviral recombination and reverse transcription
    • Hu W, Temin H. Retroviral recombination and reverse transcription. Science 1990;250:1227-33.
    • (1990) Science , vol.250 , pp. 1227-1233
    • Hu, W.1    Temin, H.2
  • 23
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of HIV type 1 than that predicted from the fidelity of purified reverse transcriptase
    • Mansky L, Temin H. Lower in vivo mutation rate of HIV type 1 than that predicted from the fidelity of purified reverse transcriptase. J Virol 1995;69:5087-94.
    • (1995) J. Virol. , vol.69 , pp. 5087-5094
    • Mansky, L.1    Temin, H.2
  • 24
    • 0032999976 scopus 로고    scopus 로고
    • The downregulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
    • Piguet V, Schwartz O, Le Gall S, Trono D. The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunol Rev 1999;168:51.
    • (1999) Immunol. Rev. , vol.168 , pp. 51
    • Piguet, V.1    Schwartz, O.2    Le Gall, S.3    Trono, D.4
  • 25
    • 0037062939 scopus 로고    scopus 로고
    • Multiply infected spleen cells in HIV patients
    • Jung A, Maier R, Vartanian J, et al. Multiply infected spleen cells in HIV patients. Nature 2002;418:144.
    • (2002) Nature , vol.418 , pp. 144
    • Jung, A.1    Maier, R.2    Vartanian, J.3
  • 26
  • 27
    • 10744226089 scopus 로고    scopus 로고
    • Recombination following superinfection by HIV-1
    • Fang G, Weiser B, Kuiken C, et al. Recombination following superinfection by HIV-1. Aids 2004;18:153-9.
    • (2004) Aids , vol.18 , pp. 153-159
    • Fang, G.1    Weiser, B.2    Kuiken, C.3
  • 28
    • 0036310370 scopus 로고    scopus 로고
    • Intersubtype HIV type 1 superinfection following seroconversion to primary infection in two injection drug users
    • Ramos A, Hu D, Nguyen L, et al. Intersubtype HIV type 1 superinfection following seroconversion to primary infection in two injection drug users. J Virol 2002;76:7444-52.
    • (2002) J. Virol. , vol.76 , pp. 7444-7452
    • Ramos, A.1    Hu, D.2    Nguyen, L.3
  • 30
    • 0038025223 scopus 로고    scopus 로고
    • Recruitment of HIV and its receptors to dendritic cell-T cell junctions
    • McDonald D, Wu L, Bohks S, KewalRamani V, Unutmaz D, Hope T. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 2003;300:1295-7.
    • (2003) Science , vol.300 , pp. 1295-1297
    • McDonald, D.1    Wu, L.2    Bohks, S.3    KewalRamani, V.4    Unutmaz, D.5    Hope, T.6
  • 31
    • 0042376485 scopus 로고    scopus 로고
    • A new classification for HIV-1
    • Berger E, Doms R, Fenyo E, et al. A new classification for HIV-1. Nature 1998;39:240.
    • (1998) Nature , vol.39 , pp. 240
    • Berger, E.1    Doms, R.2    Fenyo, E.3
  • 33
    • 0031977440 scopus 로고    scopus 로고
    • Infectious molecular clones with the nonhomologous dimer initiation sequences found in different subtypes of HIV type 1 can recombine and initiate a spreading infection in vitro
    • St Louis D, Gotte D, Sanders-Buell E, et al. Infectious molecular clones with the nonhomologous dimer initiation sequences found in different subtypes of HIV type 1 can recombine and initiate a spreading infection in vitro. J Virol 1998;72:3991-8.
    • (1998) J. Virol. , vol.72 , pp. 3991-3998
    • St Louis, D.1    Gotte, D.2    Sanders-Buell, E.3
  • 34
    • 0031594585 scopus 로고    scopus 로고
    • Retroviral recombination rates do not increase linearly with marker distance and are limited by the size of the recombining subpopulation
    • Anderson J, Bowman E, Hu W. Retroviral recombination rates do not increase linearly with marker distance and are limited by the size of the recombining subpopulation. J Virol 1998;72:1195-1202.
    • (1998) J. Virol. , vol.72 , pp. 1195-1202
    • Anderson, J.1    Bowman, E.2    Hu, W.3
  • 36
    • 0033967743 scopus 로고    scopus 로고
    • Most retroviral recombinations occur during minus-strand DNA synthesis
    • Zhang J, Tang L, Li T, Ma Y, Sapp C. Most retroviral recombinations occur during minus-strand DNA synthesis. J Virol 2000; 74:2313-22.
    • (2000) J. Virol. , vol.74 , pp. 2313-2322
    • Zhang, J.1    Tang, L.2    Li, T.3    Ma, Y.4    Sapp, C.5
  • 38
    • 0002134869 scopus 로고
    • Strand Displacement Synthesis by Reverse Transcriptase
    • Skalka A and Goff S. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Boone L, Skalka A. Strand Displacement Synthesis by Reverse Transcriptase. In Reverse Transcriptase. Skalka A and Goff S. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1993;119-33.
    • (1993) Reverse Transcriptase , pp. 119-133
    • Boone, L.1    Skalka, A.2
  • 39
    • 0001145205 scopus 로고
    • Role of Reverse Transcriptase in Retroviral Recombination
    • Skalka A and Goff S. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Hu W, Pathak V, Temin H. Role of Reverse Transcriptase in Retroviral Recombination. In Reverse Transcriptase. Skalka A and Goff S. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1993;251-74.
    • (1993) Reverse Transcriptase , pp. 251-274
    • Hu, W.1    Pathak, V.2    Temin, H.3
  • 40
    • 0141730444 scopus 로고    scopus 로고
    • In vivo characteristics of HIV type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity
    • Magiorkinis G, Paraskevis D, Vandamme A, Magiorkinis E, Sypsa V, Hatzakis A. In vivo characteristics of HIV type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity. J Gen Virol 2003;84:2715-22.
    • (2003) J. Gen. Virol. , vol.84 , pp. 2715-2722
    • Magiorkinis, G.1    Paraskevis, D.2    Vandamme, A.3    Magiorkinis, E.4    Sypsa, V.5    Hatzakis, A.6
  • 41
    • 0019956862 scopus 로고
    • Products of reverse transcription in avian retrovirus analyzed by electron microscopy
    • Junghans R, Boone L, Skalka A. Products of reverse transcription in avian retrovirus analyzed by electron microscopy. J Virol 1982: 43:544-54.
    • (1982) J. Virol. , vol.43 , pp. 544-554
    • Junghans, R.1    Boone, L.2    Skalka, A.3
  • 42
    • 0020174308 scopus 로고
    • Retroviral DNA H structures: Displacement assimilation model of recombination
    • Junghans R, Boone L, Skalka A. Retroviral DNA H structures: displacement assimilation model of recombination. Cell 1982;30:53-62.
    • (1982) Cell , vol.30 , pp. 53-62
    • Junghans, R.1    Boone, L.2    Skalka, A.3
  • 44
    • 0028144429 scopus 로고
    • Strand displacement activity of the HIV type 1 reverse transcriptase heterodimer and its individual subunits
    • Hottiger M, Podust V, Thimmig R, McHenry C, Hubscher U. Strand displacement activity of the HIV type 1 reverse transcriptase heterodimer and its individual subunits. J Biol Chem 1994;269:986-91.
    • (1994) J. Biol. Chem. , vol.269 , pp. 986-991
    • Hottiger, M.1    Podust, V.2    Thimmig, R.3    McHenry, C.4    Hubscher, U.5
  • 45
    • 0031950096 scopus 로고    scopus 로고
    • Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis
    • Bowman R, Hu W, Pathak V. Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis. J Virol 1998;72:5198-206.
    • (1998) J. Virol. , vol.72 , pp. 5198-5206
    • Bowman, R.1    Hu, W.2    Pathak, V.3
  • 46
    • 0002168527 scopus 로고
    • The genome of avian RNA tumor viruses: A discussion of four models
    • Silvestri L. (ed.). North Holland Publishing Co., Amsterdam
    • Vogt P. The genome of avian RNA tumor viruses: a discussion of four models. In Proceedings of the Fourth Lepetit Colloquium: «Possible episomes in eukaryotes». Silvestri L. (ed.). North Holland Publishing Co., Amsterdam 1973;35-41
    • (1973) Proceedings of the Fourth Lepetit Colloquium: «Possible Episomes in Eukaryotes» , pp. 35-41
    • Vogt, P.1
  • 47
    • 0024434124 scopus 로고
    • Intrinsic properties of reverse transcriptase in reverse transcription. Associated RNaseH is essentially regarded as an endonuclease
    • Oyama F, Kikuchi R, Crouch R, Uchida T. Intrinsic properties of reverse transcriptase in reverse transcription. Associated RNaseH is essentially regarded as an endonuclease. J Biol Chem 1989;264:18808-17.
    • (1989) J. Biol. Chem. , vol.264 , pp. 18808-18817
    • Oyama, F.1    Kikuchi, R.2    Crouch, R.3    Uchida, T.4
  • 48
    • 0024349238 scopus 로고
    • Ribonuclease H activities associated with viral reverse transcriptases are endonucleases
    • Krug M, Berger S. Ribonuclease H activities associated with viral reverse transcriptases are endonucleases. Proc Natl Acad Sci USA 1989;86:3539-43.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3539-3543
    • Krug, M.1    Berger, S.2
  • 50
    • 7944237580 scopus 로고    scopus 로고
    • Recognition of internal cleavage sites by retroviral RNaseH
    • Schultz S, Zhang M, Champoux J. Recognition of internal cleavage sites by retroviral RNaseH. J Vol Biol 2004;344:635-52.
    • (2004) J. Vol. Biol. , vol.344 , pp. 635-652
    • Schultz, S.1    Zhang, M.2    Champoux, J.3
  • 51
    • 0027382852 scopus 로고
    • Two defective forms of reverse transcriptase can complement to restore retroviral infectivity
    • Telesnitsky A, Goff S. Two defective forms of reverse transcriptase can complement to restore retroviral infectivity. EMBO J 1993; 12:4433-8.
    • (1993) EMBO J. , vol.12 , pp. 4433-4438
    • Telesnitsky, A.1    Goff, S.2
  • 52
    • 0018304892 scopus 로고
    • Structure, replication, and recombination of retrovirus genomes: Some unifying hypotheses
    • Coffin J. Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses. Journal of General Virology 1979;42:1-26.
    • (1979) Journal of General Virology , vol.42 , pp. 1-26
    • Coffin, J.1
  • 54
    • 0027257467 scopus 로고
    • RNaseH activity of reverse transcriptases on substrates derived from the 5′ end of retroviral genome
    • Ben-Artzi H, Zeelon E, Amit B, Wortzel A, Gorecki M, Panet A. RNaseH activity of reverse transcriptases on substrates derived from the 5′ end of retroviral genome. J Biol Chem 1993;268:16465-71.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16465-16471
    • Ben-Artzi, H.1    Zeelon, E.2    Amit, B.3    Wortzel, A.4    Gorecki, M.5    Panet, A.6
  • 55
    • 0026486193 scopus 로고
    • Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
    • Peliska J, Benkovic S. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. Science 1992;258:1112-8.
    • (1992) Science , vol.258 , pp. 1112-1118
    • Peliska, J.1    Benkovic, S.2
  • 56
    • 0026719994 scopus 로고
    • Effect of gamma radiation on retroviral recombination
    • Hu W, Temin H. Effect of gamma radiation on retroviral recombination. J Virol 1992;66:4457-63.
    • (1992) J. Virol. , vol.66 , pp. 4457-4463
    • Hu, W.1    Temin, H.2
  • 57
    • 0026646806 scopus 로고
    • Requirements for strand transfer between internal regions of heteropolymer templates by HIV reverse transcriptase
    • DeStefano J, Mallaber L, Rodriguez-Rodriguez L, Fay P, Bambara R. Requirements for strand transfer between internal regions of heteropolymer templates by HIV reverse transcriptase. J Virol 1992; 66:6370-8.
    • (1992) J. Virol. , vol.66 , pp. 6370-6378
    • DeStefano, J.1    Mallaber, L.2    Rodriguez-Rodriguez, L.3    Fay, P.4    Bambara, R.5
  • 58
    • 0028158605 scopus 로고
    • The mechanism of HlV reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates
    • DeStefano J, Bambara R, Fay P. The mechanism of HlV reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates. J Biol Chem 1994;269:161-8.
    • (1994) J. Biol. Chem. , vol.269 , pp. 161-168
    • DeStefano, J.1    Bambara, R.2    Fay, P.3
  • 59
    • 0028819607 scopus 로고
    • Strand transfer mediated by HIV reverse transcriptase in vitro is promoted by pausing and results in misincorporation
    • Wu W, Blumberg B, Fay P, Bambara R. Strand transfer mediated by HIV reverse transcriptase in vitro is promoted by pausing and results in misincorporation. J Biol Chem 1995;270:325-32.
    • (1995) J. Biol. Chem. , vol.270 , pp. 325-332
    • Wu, W.1    Blumberg, B.2    Fay, P.3    Bambara, R.4
  • 60
    • 23144448275 scopus 로고    scopus 로고
    • Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: Critical role in reverse transcription and molecular mechanism
    • Levin J, Guo J, Rouzina I, Musier-Forsyth K. Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism. Prog Nucleic Acids Res Mol Biol 2005;80:217-86-.
    • (2005) Prog. Nucleic Acids Res. Mol. Biol. , vol.80 , pp. 217-286
    • Levin, J.1    Guo, J.2    Rouzina, I.3    Musier-Forsyth, K.4
  • 61
    • 0029009007 scopus 로고
    • Influence of HIV nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro
    • Rodriguez-Rodriguez L, Tsuchihashi Z, Fuentes G, Bambara R, Fay P. Influence of HIV nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro. J Biol Chem 1995; 270:15005-11.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15005-15011
    • Rodriguez-Rodriguez, L.1    Tsuchihashi, Z.2    Fuentes, G.3    Bambara, R.4    Fay, P.5
  • 62
    • 0033586736 scopus 로고    scopus 로고
    • Kinetic analysis of the effect of HIV nucleocapsid protein (NCp) on internal strand transfer reactions
    • Raja A, DeStefano J. Kinetic analysis of the effect of HIV nucleocapsid protein (NCp) on internal strand transfer reactions. Biochemistry 1999;38:5178-84.
    • (1999) Biochemistry , vol.38 , pp. 5178-5184
    • Raja, A.1    DeStefano, J.2
  • 63
    • 0028836727 scopus 로고
    • HIV nucleocapsid protein stimulates strand transfer from internal regions of heteropolymeric RNA templates
    • DeStefano J. HIV nucleocapsid protein stimulates strand transfer from internal regions of heteropolymeric RNA templates. Arch Virol 1995;140:1775-89.
    • (1995) Arch. Virol. , vol.140 , pp. 1775-1789
    • DeStefano, J.1
  • 64
    • 0038521273 scopus 로고    scopus 로고
    • Evidence for the differential effects of nucleocapsid protein on strand transfer in various regions of the HIV genome
    • Derebail S, Heath M, DeStefano J. Evidence for the differential effects of nucleocapsid protein on strand transfer in various regions of the HIV genome. J Biol Chem 2003;278:15702-12.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15702-15712
    • Derebail, S.1    Heath, M.2    DeStefano, J.3
  • 65
    • 0000333554 scopus 로고    scopus 로고
    • Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1
    • Kim J, Palaniappan C, Wu W, Fay P, Bambara R. Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1. J Biol Chem 1997;272:16769-77.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16769-16777
    • Kim, J.1    Palaniappan, C.2    Wu, W.3    Fay, P.4    Bambara, R.5
  • 66
    • 0034612340 scopus 로고    scopus 로고
    • Copy-choice recombination by reverse transcriptases: Reshuffling of genetic markers mediated by RNA chaperones
    • Negroni M, Buc H. Copy-choice recombination by reverse transcriptases: reshuffling of genetic markers mediated by RNA chaperones. Proc Natl Acad Sci USA 2000;97:6385-90.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6385-6390
    • Negroni, M.1    Buc, H.2
  • 67
    • 0037033049 scopus 로고    scopus 로고
    • Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism
    • Roda R, Balakrishnan M, Kim J, Roques B, Fay P, Bambara R. Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. J Biol Chem 2002;277:46900-11.
    • (2002) J. Biol. Chem. , vol.277 , pp. 46900-46911
    • Roda, R.1    Balakrishnan, M.2    Kim, J.3    Roques, B.4    Fay, P.5    Bambara, R.6
  • 68
    • 0037844873 scopus 로고    scopus 로고
    • Evidence for a mechanism of recombination during reverse transcription dependent on the structure of the acceptor RNA
    • Moumen A, Polomack L, Unge T, Veron M, Buc H, Negroni M. Evidence for a mechanism of recombination during reverse transcription dependent on the structure of the acceptor RNA. J Biol Chem 2003;278:15973-82.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15973-15982
    • Moumen, A.1    Polomack, L.2    Unge, T.3    Veron, M.4    Buc, H.5    Negroni, M.6
  • 69
    • 0033548241 scopus 로고    scopus 로고
    • Recombination during reverse transcription: An evaluation of the role of the nucleocapsid protein
    • Negroni M, Buc H. Recombination during reverse transcription: an evaluation of the role of the nucleocapsid protein. J Mol Biol 1999;286:15-31.
    • (1999) J. Mol. Biol. , vol.286 , pp. 15-31
    • Negroni, M.1    Buc, H.2
  • 70
    • 0027377963 scopus 로고
    • Low levels of deoxynucleotides in peripheral blood lymphocytes: A strategy to inhibit HIV type 1 replication
    • Gao W, Cara A, Gallo R, Lori F. Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit HIV type 1 replication. Proc Natl Acad Sci USA 1993;90:8925-8.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8925-8928
    • Gao, W.1    Cara, A.2    Gallo, R.3    Lori, F.4
  • 71
    • 0032860801 scopus 로고    scopus 로고
    • Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription
    • Pfeiffer J, Topping R, Shin N, Telesnitsky A. Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription. J Virol 1999;73:8441-7.
    • (1999) J. Virol. , vol.73 , pp. 8441-8447
    • Pfeiffer, J.1    Topping, R.2    Shin, N.3    Telesnitsky, A.4
  • 72
    • 0033927974 scopus 로고    scopus 로고
    • Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching
    • Svarovskaia E, Delvilks K, Hwang C, Pathak V. Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching. J Virol 2000;74:7171-8.
    • (2000) J. Virol. , vol.74 , pp. 7171-7178
    • Svarovskaia, E.1    Delvilks, K.2    Hwang, C.3    Pathak, V.4
  • 73
    • 0023785829 scopus 로고
    • Inhibition of HIV (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′-dideoxynucleosides
    • Perno C, Yarchoan R, Cooney D, et al. Inhibition of HIV (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′-dideoxynucleosides. J Exp Med 1988;168:1111-25.
    • (1988) J. Exp. Med. , vol.168 , pp. 1111-1125
    • Perno, C.1    Yarchoan, R.2    Cooney, D.3
  • 74
    • 0028054837 scopus 로고
    • Kinetics of HIV type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors
    • O'Brien W, Namazi A, Kalhor H, Mao S, Zack J, Chen I. Kinetics of HIV type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors. J Virol 1994; 68:1258-63.
    • (1994) J. Virol. , vol.68 , pp. 1258-1263
    • O'Brien, W.1    Namazi, A.2    Kalhor, H.3    Mao, S.4    Zack, J.5    Chen, I.6
  • 75
    • 0035965239 scopus 로고    scopus 로고
    • The kissing hairpin sequence promotes recombination within the HIV-1 5′ leader region
    • Balakrishnan M, Fay P, Bambara R. The kissing hairpin sequence promotes recombination within the HIV-1 5′ leader region. J Biol Chem 2001;276:36482-92.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36482-36492
    • Balakrishnan, M.1    Fay, P.2    Bambara, R.3
  • 76
    • 0035883822 scopus 로고    scopus 로고
    • The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination
    • Moumen A, Polomack L, Roques B, Buc H, Negroni M. The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination. Nucleic Acids Res 2001;29:3814-21.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3814-3821
    • Moumen, A.1    Polomack, L.2    Roques, B.3    Buc, H.4    Negroni, M.5
  • 77
    • 0030753504 scopus 로고    scopus 로고
    • Effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 reverse transcriptase
    • Suo Z, Johnson K. Effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 reverse transcriptase. Biochemistry 1997;36:12459-67.
    • (1997) Biochemistry , vol.36 , pp. 12459-12467
    • Suo, Z.1    Johnson, K.2
  • 78
    • 4344592441 scopus 로고    scopus 로고
    • The structure of HIV-1 genomic RNA in the gp120 gene determines a recombination hot spot in vivo
    • Galetto R, Moumen A, Giacomoni V, Veron M, Charneau P, Negroni M. The structure of HIV-1 genomic RNA in the gp120 gene determines a recombination hot spot in vivo. J Biol Chem 2004;279:36625-32.
    • (2004) J. Biol. Chem. , vol.279 , pp. 36625-36632
    • Galetto, R.1    Moumen, A.2    Giacomoni, V.3    Veron, M.4    Charneau, P.5    Negroni, M.6
  • 79
    • 0042858256 scopus 로고    scopus 로고
    • Role of the reverse transcriptase, nucleocapsid protein, and template structure in the two-step transfer mechanism in retroviral recombination
    • Roda R, Balakrishnan M, Hanson M, et al. Role of the reverse transcriptase, nucleocapsid protein, and template structure in the two-step transfer mechanism in retroviral recombination. J Biol Chem 2003;278:31536-46.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31536-31546
    • Roda, R.1    Balakrishnan, M.2    Hanson, M.3
  • 80
    • 0033582952 scopus 로고    scopus 로고
    • The effect of template RNA structure on elongation by HIV-1 reverse transcriptase
    • Klasens B, Huthoff H, Des A, Jeeninga R, Berkhout B. The effect of template RNA structure on elongation by HIV-1 reverse transcriptase. Biochim Biophys Acta 1999;1444:355-70.
    • (1999) Biochim. Biophys. Acta , vol.1444 , pp. 355-370
    • Klasens, B.1    Huthoff, H.2    Des, A.3    Jeeninga, R.4    Berkhout, B.5
  • 81
    • 0037260333 scopus 로고    scopus 로고
    • Nucleic acid conformational changes essential for HIV-1 nucleocapsid protein-mediated inhibition of self-priming in minus-strand transfer
    • Hong M, Harbron E, O'Connor D, et al. Nucleic acid conformational changes essential for HIV-1 nucleocapsid protein-mediated inhibition of self-priming in minus-strand transfer. J Mol Biol 2003;325:1-10.
    • (2003) J. Mol. Biol. , vol.325 , pp. 1-10
    • Hong, M.1    Harbron, E.2    O'Connor, D.3
  • 82
    • 0037453234 scopus 로고    scopus 로고
    • Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7
    • Beltz H, Azoulay J, Bernacchi S, et al. Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7. J Mol Biol 2003;328:95-108.
    • (2003) J. Mol. Biol. , vol.328 , pp. 95-108
    • Beltz, H.1    Azoulay, J.2    Bernacchi, S.3
  • 83
    • 1942457321 scopus 로고    scopus 로고
    • Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7
    • Beltz H, Piemont E, Schaub E, et al. Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7. J Mol Biol 2004;338:711-23.
    • (2004) J. Mol. Biol. , vol.338 , pp. 711-723
    • Beltz, H.1    Piemont, E.2    Schaub, E.3
  • 84
    • 6344294990 scopus 로고    scopus 로고
    • Alteration of nucleic acid structure and stability modulates the efficiency of minus-strand transfer mediated by the HIV-1 nucleocapsid protein
    • Heilman-Miller S, Wu T, Levin J. Alteration of nucleic acid structure and stability modulates the efficiency of minus-strand transfer mediated by the HIV-1 nucleocapsid protein. J Biol Chem 2004;279:44154-65.
    • (2004) J. Biol. Chem. , vol.279 , pp. 44154-44165
    • Heilman-Miller, S.1    Wu, T.2    Levin, J.3
  • 85
    • 18044365239 scopus 로고    scopus 로고
    • Specific interactions between HIV-1 nucleocapsid protein and the TAR element
    • Kanevsky I, Chaminade F, Ficheux D, et al. Specific interactions between HIV-1 nucleocapsid protein and the TAR element. J Mol Biol 2005;348:1059-77.
    • (2005) J. Mol. Biol. , vol.348 , pp. 1059-1077
    • Kanevsky, I.1    Chaminade, F.2    Ficheux, D.3
  • 86
    • 0036827628 scopus 로고    scopus 로고
    • HIV type 1 recombination: Rate, fidelity, and putative hot spots
    • Zhuang J, Jetzt A, Sun G, et al. HIV type 1 recombination: rate, fidelity, and putative hot spots. J Virol 2002;76:11273-82.
    • (2002) J. Virol. , vol.76 , pp. 11273-11282
    • Zhuang, J.1    Jetzt, A.2    Sun, G.3
  • 87
    • 0036314411 scopus 로고    scopus 로고
    • Effects of varying sequence similarity on the frequency of repeat deletion during reverse transcription of a HIV type 1 vector
    • An W, Telesnitsky A. Effects of varying sequence similarity on the frequency of repeat deletion during reverse transcription of a HIV type 1 vector. J Virol 2002;76:7897-902.
    • (2002) J. Virol. , vol.76 , pp. 7897-7902
    • An, W.1    Telesnitsky, A.2
  • 88
    • 0035167124 scopus 로고    scopus 로고
    • Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication
    • Pfeiffer J, Telesnitsky A. Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication. J Virol 2001;75:11263-74.
    • (2001) J. Virol. , vol.75 , pp. 11263-11274
    • Pfeiffer, J.1    Telesnitsky, A.2
  • 89
    • 0027339344 scopus 로고
    • Rate and mechanism of nonhomologous recombination during a single cycle of retroviral replication
    • Zhang J, Temin H. Rate and mechanism of nonhomologous recombination during a single cycle of retroviral replication. Science 1993;259:234-8.
    • (1993) Science , vol.259 , pp. 234-238
    • Zhang, J.1    Temin, H.2
  • 90
    • 0028274130 scopus 로고
    • Retrovirus recombination depends on the length of sequence identity and is not error prone
    • Zhang J, Temin H. Retrovirus recombination depends on the length of sequence identity and is not error prone. J Virol 1994;68:2409-14.
    • (1994) J. Virol. , vol.68 , pp. 2409-2414
    • Zhang, J.1    Temin, H.2
  • 91
    • 0036838722 scopus 로고    scopus 로고
    • Selection for HIV type 1 recombinants in a patient with rapid progression to AIDS
    • Liu S, Mittler J, Nickle D, et al. Selection for HIV type 1 recombinants in a patient with rapid progression to AIDS. J Virol 2002; 76:10674-84.
    • (2002) J. Virol. , vol.76 , pp. 10674-10684
    • Liu, S.1    Mittler, J.2    Nickle, D.3
  • 92
    • 4644245699 scopus 로고    scopus 로고
    • Pervasive genomic recombination of HIV-1 in vivo
    • Shriner D, Rodrigo A, Nickle D, Mullins J. Pervasive genomic recombination of HIV-1 in vivo. Genetics 2004;167:1573-83.
    • (2004) Genetics , vol.167 , pp. 1573-1583
    • Shriner, D.1    Rodrigo, A.2    Nickle, D.3    Mullins, J.4
  • 93
    • 0036999990 scopus 로고    scopus 로고
    • Genetic recombination and its role in the development of the HlV-1 pandemic
    • Najera R, Delgado E, Perez-Alvarez L, Thomson M. Genetic recombination and its role in the development of the HlV-1 pandemic. Aids 2002;16(Suppl 4):S3-16.
    • (2002) Aids , vol.16 , Issue.SUPPL. 4
    • Najera, R.1    Delgado, E.2    Perez-Alvarez, L.3    Thomson, M.4
  • 94
    • 0032710838 scopus 로고    scopus 로고
    • Consistent viral evolutionary changes associated with the progression of HIV type 1 infection
    • Shankarappa R, Margolick J, Gange S, et al. Consistent viral evolutionary changes associated with the progression of HIV type 1 infection. J Virol 1999;73:10489-502.
    • (1999) J. Virol. , vol.73 , pp. 10489-10502
    • Shankarappa, R.1    Margolick, J.2    Gange, S.3
  • 95
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
    • Molla A, Korneyeva M, Gao Q, et al. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat Med 1996;2:760-6.
    • (1996) Nat. Med. , vol.2 , pp. 760-766
    • Molla, A.1    Korneyeva, M.2    Gao, Q.3
  • 96
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano J, et al. Latent infection of CD4+ T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999;5:512-7.
    • (1999) Nat. Med. , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.3
  • 97
    • 12944335238 scopus 로고    scopus 로고
    • Antiretroviral resistance during successful therapy of HIV type 1 infection
    • Martinez-Picado J, DePasquale M, Kartsonis N, et al. Antiretroviral resistance during successful therapy of HIV type 1 infection. Proc Natl Acad Sci USA 2000;97:10948-53.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10948-10953
    • Martinez-Picado, J.1    DePasquale, M.2    Kartsonis, N.3
  • 98
    • 0027486945 scopus 로고
    • Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro
    • Larder B, Kellam P, Kemp S. Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro. Nature 1993;365:451-3.
    • (1993) Nature , vol.365 , pp. 451-453
    • Larder, B.1    Kellam, P.2    Kemp, S.3
  • 99
    • 0037189323 scopus 로고    scopus 로고
    • Diversity considerations in HIV-1 vaccine selection
    • Gaschen B, Taylor J, Yusim K, et al. Diversity considerations in HIV-1 vaccine selection. Science 2002;296:2354-60.
    • (2002) Science , vol.296 , pp. 2354-2360
    • Gaschen, B.1    Taylor, J.2    Yusim, K.3
  • 100
    • 0034978733 scopus 로고    scopus 로고
    • Genetic subtypes, humoral immunity, and HIV type 1 vaccine development
    • Moore J, Parren P, Burton D. Genetic subtypes, humoral immunity, and HIV type 1 vaccine development. J Virol 2001;75:5721-9.
    • (2001) J. Virol. , vol.75 , pp. 5721-5729
    • Moore, J.1    Parren, P.2    Burton, D.3
  • 101
    • 13944277994 scopus 로고    scopus 로고
    • Multiclade HIV type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys
    • Seaman M, Xu L, Beaudry K, et al. Multiclade HIV type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys. J Virol 2005;79:2956-63.
    • (2005) J. Virol. , vol.79 , pp. 2956-2963
    • Seaman, M.1    Xu, L.2    Beaudry, K.3
  • 102
    • 0031763875 scopus 로고    scopus 로고
    • Genetic variation of HIV type 1: Relevance of interclade variation to vaccine development
    • Van der Groen G, Nyambi P, Beirnaert E, et al. Genetic variation of HIV type 1: relevance of interclade variation to vaccine development. AIDS Res Hum Retroviruses 1998;14(Suppl 3):S211-221.
    • (1998) AIDS Res. Hum. Retroviruses , vol.14 , Issue.SUPPL. 3
    • Van der Groen, G.1    Nyambi, P.2    Beirnaert, E.3
  • 103
    • 3142670662 scopus 로고    scopus 로고
    • Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys
    • Letvin N, Huang Y, Chakrabarti B, et al. Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys. J Virol 2004;78:7490-7.
    • (2004) J. Virol. , vol.78 , pp. 7490-7497
    • Letvin, N.1    Huang, Y.2    Chakrabarti, B.3
  • 104
    • 13844302894 scopus 로고    scopus 로고
    • Structure of an unliganded simian immunodeficiency virus gp120 core
    • Chen B, Vogan E, Gong H, Skehel J, Wiley D, Harrison S. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature 2005;433:834-41.
    • (2005) Nature , vol.433 , pp. 834-841
    • Chen, B.1    Vogan, E.2    Gong, H.3    Skehel, J.4    Wiley, D.5    Harrison, S.6
  • 105
    • 0025838698 scopus 로고
    • A large array of human monoclonal antibodies to type 1 HIV from combinatorial libraries of asymptomatic seropositive individuals
    • Burton D, Barbas C 3rd, Persson M, Koenig S, Chanock R, Lerner R. A large array of human monoclonal antibodies to type 1 HIV from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci USA 1991;88:10134-7.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10134-10137
    • Burton, D.1    Barbas III, C.2    Persson, M.3    Koenig, S.4    Chanock, R.5    Lerner, R.6
  • 106
    • 0026655937 scopus 로고
    • Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro
    • Barbas C 3rd, Bjorling E, Chiodi F, et al. Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro. Proc Natl Acad Sci USA 1992;89:9339-43.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9339-9343
    • Barbas III, C.1    Bjorling, E.2    Chiodi, F.3
  • 107
    • 0027985431 scopus 로고
    • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
    • Burton D, Pyati J, Koduri R, et al. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 1994;266:1024-7.
    • (1994) Science , vol.266 , pp. 1024-1027
    • Burton, D.1    Pyati, J.2    Koduri, R.3
  • 108
    • 0028291731 scopus 로고
    • Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize HIV type 1
    • Roben P, Moore J, Thali M, Sodroski J, Barbas C 3rd, Burton D. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize HIV type 1. J Virol 1994;68:4821-8.
    • (1994) J. Virol. , vol.68 , pp. 4821-4828
    • Roben, P.1    Moore, J.2    Thali, M.3    Sodroski, J.4    Barbas III, C.5    Burton, D.6
  • 109
    • 0033809610 scopus 로고    scopus 로고
    • Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary HIV type 1 isolate
    • Cho M, Lee M, Chen C, Matthews T, Martin M. Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary HIV type 1 isolate. J Virol 2000;74:9749-54.
    • (2000) J. Virol. , vol.74 , pp. 9749-9754
    • Cho, M.1    Lee, M.2    Chen, C.3    Matthews, T.4    Martin, M.5
  • 110
    • 4043060710 scopus 로고    scopus 로고
    • Correlates of immune protection in HIV-1 infection: What we know, what we don't know, what we should know
    • Pantaleo G, Koup R. Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat Med 2004:10:806-10.
    • (2004) Nat. Med. , vol.10 , pp. 806-810
    • Pantaleo, G.1    Koup, R.2


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