Altering the intracellular environment increases the frequency of tandem repeat deletion during moloney murine leukemia virus reverse transcription

Journal of Virology

Volumn 73, Issue 10, 1999, Pages 8441-8447

  Pfeiffer, Julie K ^a   Topping, Robert S ^a,b   Shin, Nam Hee ^a   Telesnitsky, Alice ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYUREA; NUCLEOTIDE; RNA DIRECTED DNA POLYMERASE;

ANIMAL CELL; ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; DNA SYNTHESIS; GENE REARRANGEMENT; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; TANDEM REPEAT; VIRUS RECOMBINATION;

EID: 0032860801     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.8441-8447.1999     Document Type: Article

References (45)

1. Anderson, J. A., E. H. Bowman, and W.-S. Hu. 1998. Retroviral recombination rates do not increase linearly with marker distance and are limited by the size of the recombining subpopulation. J. Virol. 72:1195-1202.
2. Back, N. K. T., and B. Berkhout. 1997. Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 41:2484-2491.
3. Bowman, R. R., W.-S. Hu, and V. K. Pathak. 1998. Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis. J. Virol. 72:5198-5206.
4. Buckle, M., R. M. Williams, M. Negroni, and H. Buc. 1996. Real time measurements of elongation by a reverse transcriptase using surface plasmon resonance. Proc. Natl. Acad. Sci. USA 93:889-894.
5. Bukrinsky, M. I., T. L. Stanwick, M. P. Dempsey, and M. Stevenson. 1991. Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science 254:423-427.
6. Coffin, J. M. 1979. Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses. J. Gen. Virol. 42:1-26.
7. Colicelli, J., and S. P. Goff. 1988. Sequence and spacing requirements of a retrovirus integration site. J. Mol. Biol. 199:47-59.
8. Delviks, K. A., W.-S. Hu, and V. K. Pathak. 1997. ψ-Vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors. J. Virol. 71:6218-6224.
9. Emerman, M., and H. M. Temin. 1984. Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism. Cell 39:459-467.
10. Fisher, J., and S. P. Goff. 1998. Mutual analysis of stem-loops in the RNA packaging signal of the Moloney murine leukemia virus. Virology 244:133-145.
11. Gilboa, E., S. W. Mitra, S. Goff, and D. Baltimore. 1979. A detailed model of reverse transcription and tests of crucial aspects. Cell 18:93-100.
12. 0-arrested Balb c/3T3 fibroblasts. Virology 200:87-97.
13. Hu, W.-S., E. H. Bowman, K. A. Delviks, and V. K. Pathak. 1997. Homologous recombination occurs in a distinct retroviral subpopulation and exhibits high negative interference. J. Virol. 71:6028-6036.
14. Hu, W.-S., and H. M. Temin. 1992. Effect of gamma radiation on retroviral recombination. J. Virol. 66:4457-4463.
15. Hu, W.-S., and H. M. Temin. 1990. Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination. Proc. Natl. Acad. Sci. USA 87:1556-1560.
16. Huber, H. E., J. M. McCoy, J. S. Seehra, and C. C. Richardson. 1989. Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis and template switching. J. Biol. Chem. 264:4669-4678.
17. Jin, D. J., R. R. Burgess, J. P. Richardson, and C. A. Gross. 1992. Termination efficiency at rho-dependent terminators depends on kinetic coupling between RNA polymerase and rho. Proc. Natl. Acad. Sci. USA 89:1453-1457.
18. m for purine nucleotides during transcription elongation. J. Biol. Chem. 266:14478-14485.
19. Jones, J. S., R. W. Allan, and H. M. Temin. 1994. One retroviral RNA is sufficient for synthesis of viral DNA. J. Virol. 68:207-216.
20. - vectors: development of novel self-inactivating and self-activating vectors for safer gene therapy. J. Virol. 69:6839-6846.
21. Julias, J. G., and V. K. Pathak. 1998. Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate. J. Virol. 72:7941-7949.
22. Katz, R. A., and A. M. Skalka. 1990. Generation of diversity in retroviruses. Annu. Rev. Genet. 24:409-445.
23. Kulpa, D., R. Topping, and A. Telesnitsky. 1997. Determination of the site of first strand transfer during Moloney murine leukemia virus reverse transcription and identification of strand transfer-associated reverse transcriptase errors. EMBO J. 16:856-865.
24. Larson, V., and A. Telesnitsky. Unpublished data.
25. Martin-Hernandez, A. M., E. Domingo, and L. Menendez-Arias. 1996. Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynudeotide binding and misinsertion fidelity of DNA synthesis. EMBO J. 15:4434-4442.
26. McDowell, J. C., J. W. Roberts, D. J. Jin, and C. Gross. 1994. Determination of intrinsic transcription termination efficiency by RNA polymerase elongation rate. Science 266:822-825.
27. Morgenstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587-3596.
28. Nagy, P. D., and A. E. Simon. 1997. New insights into the mechanisms of RNA recombination. Virology 235:1-9.
29. O'Brien, W. A., A. Namazi, H. Kalhor, S. H. Mao, J. A. Zack, and I. S. Chen. 1994. Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors. J. Virol. 68:1258-1263.
30. Pandey, V. N., N. Kaushik, N. Rege, S. G. Sarafianos, P. N. S. Yadav, and M. J. Modak. 1996. Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis. Biochemistry 35:2168-2179.
31. Parthasarathi, S., A. Varela-Echavarria, V. Ron, B. D. Preston, and J. P. Dougherty. 1995. Genetic rearrangements occurring during a single cycle of murine leukemia virus vector replication: characterization and implications. J. Virol. 69:7991-8000.
32. Pathak, V. K., and H. M. Temin. 1990. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions. Proc. Natl. Acad. Sci. USA 87:6024-6028.
33. Pathak, V. K., and H. M. Temin. 1990. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations. Proc. Nati. Acad. Sci. USA 87:6019-6023.
34. Preston, B. D., and J. P. Dougherty. 1996. Mechanisms of retroviral mutation. Trends Microbiol. 4:16-21.
35. Price, J., D. Turner, and C. Cepko. 1987. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA 84:156-160.
36. Pulsinelli, G. A., and H. M. Temin. 1991. Characterization of large deletions occurring during a single round of retrovirus replication: novel deletion mechanism involving errors in strand transfer. J. Virol. 65:4786-4797.
37. Rhode, B. W., M. Emerman, and H. M. Temin. 1987. Instability of large direct repeats in retrovirus vectors. J. Virol. 61:925-927.
38. Temin, H. M. 1993. Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation. Proc. Natl. Acad. Sci. USA 90:6900-6903.
39. Wainberg, M. A., W. C. Drosopoulos, H. Salomon, M. Hsu, G. Borkow, M. A. Parniak, Z. Gu, Q. Song, J. Manne, S. Islam, G. Castriota, and V. R. Prasad. 1996. Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science 271:1282-1285.
40. Wooley, D. P., L. A. Bircher, and R. A. Smith. 1998. Retroviral recombination is nonrandom and sequence dependent. Virology 243:229-234.
41. Xu, H., and J. D. Boeke. 1987. High-frequency deletion between homologous sequences during retrotransposition of Ty elements in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 84:8553-8557.
42. Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Y. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213-222.
43. Zack, J. A., A. M. Haislip, P. Krogstad, and I. S. Y. Chen. 1992. Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle. J. Virol. 66:1717-1725.
44. Zhang, J., and H. M. Temin. 1993. Rate and mechanism of nonhomologous recombination during a single cycle of retroviral replication. Science 259: 234-238.
45. Zhang, J., and H. M. Temin. 1994. Retrovirus recombination depends on the length of sequence identity and is not error prone. J. Virol. 68:2409-2414.