Carving the active site of almond R-HNL for increased enantioselectivity

Angewandte Chemie - International Edition

Volumn 44, Issue 30, 2005, Pages 4700-4704

  Weis, Roland ^a   Gaisberger, Richard ^a   Skranc, Wolfgang ^b   Gruber, Karl ^a   Glieder, Anton ^a  

^a RESEARCH CENTRE APPLIED BIOCATALYSIS   (Austria)

^b DSM Fine Chemicals Austria Nfg GmbH & Co KG   (Netherlands)

Author keywords

ACE inhibitors; Asymmetric synthesis; Biocatalysis; Hydroxynitrile lyase; Protein engineering

Indexed keywords

DRUG PRODUCTS; SUBSTRATES; SYNTHESIS (CHEMICAL);

ALMONDS; CHIRAL BUILDING BLOCKS; MUTEINS;

SEED;

CYANOHYDRIN; HYDROXYMANDELONITRILE LYASE; ISOENZYME; LYASE; NITRILE; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CONFORMATION; ENZYMOLOGY; PRUNUS; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALDEHYDE-LYASES; BINDING SITES; CATALYSIS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRILES; PRUNUS; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

DRUGS; SEEDS; SYNTHESIS;

EID: 23044496747     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500435     Document Type: Article

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