5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons

Anesthesia and Analgesia

Volumn 96, Issue 4, 2003, Pages 1027-1031

  Koshizaki, Masayuki ^a   Kawamata, Mikito ^a   Shimada, Steven G ^a   Saito, Yoji ^a   Collins, J G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE; INHALATION ANESTHETIC AGENT; KETANSERIN; METHYSERGIDE; METITEPINE; NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM BROMIDE; SEROTONIN 1 ANTAGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN ANTAGONIST; TROPISETRON; INDOLE DERIVATIVE; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; GENERAL ANESTHESIA; INHALATION ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SEROTONINERGIC SYSTEM; SPINAL CORD DORSAL HORN; SPINAL CORD TRANSSECTION; ANIMAL; CHEMICAL PHENOMENA; CYTOLOGY; DECEREBRATION; PATHOPHYSIOLOGY; POSTERIOR HORN CELL; SENSORY NERVE CELL; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANESTHETICS, INHALATION; ANIMALS; DECEREBRATE STATE; DEPRESSION, CHEMICAL; HALOTHANE; INDOLES; KETANSERIN; METHIOTHEPIN; METHYSERGIDE; NEURONS, AFFERENT; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; SPINAL CORD;

EID: 0037377839     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000050769.34933.03     Document Type: Article

References (17)

1. Brown AG. Organization in the spinal cord: the anatomy and physiology of identified neurons. Berlin: Springer-Verlag, 1981.
2. Willis WD, Coggeshall RE. Sensory mechanisms of the spinal cord. 2nd ed. New York: Plenum, 1991.
3. Davidoff RA, ed. Handbook of the spinal cord. Vol. 2-3. Anatomy and Physiology. New York: Marcel Dekker, 1987.
4. A nor strychnine sensitive glycine receptor systems are the sole mediators of halothane depression of spinal dorsal horn sensory neurons. Anesth Analg. In press.
5. A and glycine receptor systems. Anesthesiology 2002;97:412-7.
6. A nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane. Anesth Analg 2001;92:123-7.
7. Ortells MO, Lunt GG. Evolutionary history of the ligand-gated ion-channel superfamily of receptors. Trends Neurosci 1995;18:121-7.
8. Handwerker HO, Iggo A, Zimmermann M. Segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli. Pain 1975;1:147-65.
9. Belcher G, Ryall RW, Schaffner R. The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurons in the cat. Brain Res 1978;151:307-21.
10. Griersmith BT, Duggan AW. Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methysergide. Brain Res 1980;187:231-6.
11. Saito Y, Collins JG, Iwasaki H. Tonic 5-HT modulation of spinal dorsal horn neuron activity evoked by both noxious and nonnoxious stimuli: a source of neuronal plasticity. Pain 1990;40:205-19.
12. Yamamori Y, Kishikawa K, Collins JG. Halothane effects on low-threshold receptive field size of rat spinal dorsal horn neurons appear to be independent of supraspinal modulatory systems. Brain Res 1995;702:162-8.
13. 3 receptor antagonist. Neurosci Lett 1988;95:313-7.
14. Glaum SR, Proudfit HK, Anderson EG. 5-HT receptors modulate spinal nociceptive reflexes. Brain Res 1990;510:12-6.
15. 3 receptors expressed in Xenopus laevis oocytes. J Pharmacol Exp Ther 1994;271:898-905.
16. Yanagidani T, Ota K, Collins JG. Complex effects of general anesthesia on sensory processing in the spinal dorsal horn. Brain Res 1998;812:301-4.
17. 3 receptor does not alter isoflurane MAC in rats. Anesthesiology 2001;95:562-4.