Sequence variations in the flavin-containing mono-oxygenase 3 gene (FMO3) in fish odour syndrome

British Journal of Dermatology

Volumn 140, Issue 1, 1999, Pages 164-167

  Basarab, T ^a   Ashton, G H S ^a   Menage H D P ^a   McGrath, J A ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Fish odour syndrome; Flavin containing monoxygenase 3; Sequence variations; Trimethylaminuria

Indexed keywords

TRIMETHYLAMINE; UNSPECIFIC MONOOXYGENASE;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CASE REPORT; CLINICAL FEATURE; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; ODOR; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SWEATING;

ADULT; ANIMALS; EXONS; FISHES; HUMANS; MALE; METABOLIC DISEASES; MUTATION, MISSENSE; ODORS; OXYGENASES; POLYMORPHISM, GENETIC; SYNDROME;

EID: 0033008190     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.02693.x     Document Type: Article

References (15)

1. al-Waiz M, Ayesh R, Mitchell SC et al. Trimethylaminuria (fish-odour syndrome): An inborn error of oxidative metabolism. Lancet 1987; i: 634-5.
2. al-Waiz M, Ayesh R, Mitchell SC et al. Trimethylaminuria ('fish-odour syndrome'): A study of an affected family. Clin Sci 1988; 74: 231-6.
3. Ayesh R, Mitchell SC, Zhang A, Smith RL. The fish-odour syndrome: Biochemical, familial and clinical aspects. Br Med J 1993; 307: 655-7.
4. Mitchell SC. The fish-odour syndrome. Perspect Biol Med 1996; 39: 514-26.
5. Shelley ED, Shelley WD. The fish-odor syndrome: Trimethylaminuria. JAMA 1984; 251: 253-5.
6. Spellacy E, Watts RWE, Goollamali SK. Trimethylaminuria. J Inherited Metab Dis 1979; 2: 85-8.
7. Gut I, Conney AH. Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes. Biochem Pharmacol 1993; 46: 239-44.
8. Ziegler DM. Flavin-containing monooxygenases: Enzymes adapted for multisubstrate specificity. Trends Pharmacol Sci 1990; 11: 321-4.
9. Phillips IR, Dolphin CT, Clair P et al. The molecular biology of the flavin-containing monooxygenases of man. Chem Biol Interact 1995; 96: 17-32.
10. Dolphin CT, Cullingford TE, Shephard EA et al. Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FMO4. Eur J Biochem 1996; 235: 683-9.
11. Dolphin CT, Janmohamed A, Smith RL et al. Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nat Genetics 1997; 17: 491-4.
12. Marks R, Greaves MW, Prottey C. Trimethylaminuria: The use of choline as an aid to diagnosis. Br J Dermatol 1977; 96: 399-402.
13. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
14. Dolphin CT, Riley JR, Smith RL et al. Structural organization of the human flavin-containing monooxygenase gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. Genomics 1997; 46: 260-7.
15. Ganguly A, Rock MJ, Prockop DJ. Conformation-sensitive gel electrophoresis for rapid detection of single base differences in double-stranded PCR products and DNA fragments: Evidence for solvent-induced bends in DNA heteroduplexes. Proc Natl Acad Sci USA 1993; 90: 10325-9.