SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons

British Journal of Pharmacology

Volumn 145, Issue 6, 2005, Pages 728-739

  Wen, Lei ^a   Yang, Sheng ^a   Qiao, Haifa ^a   Liu, Zhenwei ^a   Zhou, Wenxia ^a   Zhang, Yongxiang ^a   Huang, Peitang ^b  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

conotoxins; Hippocampal neurons; N type calcium channel blockers; Pain; Patch clamp techniques; SO 3; Voltage sensitive calcium channels; Voltage sensitive potassium channels; Voltage sensitive sodium channels

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CALCIUM CHANNEL R TYPE; CONOPEPTIDE; NIMODIPINE; OMEGA AGATOXIN IVA; OMEGA CONOTOXIN MVIIA; PEPTIDE; SO 3 PEPTIDE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONUS STRIATUS; HIPPOCAMPUS; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PAIN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; SIGNAL TRANSDUCTION; SNAIL;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELLS, CULTURED; HIPPOCAMPUS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; NEURONS; NIMODIPINE; OMEGA-AGATOXIN IVA; OMEGA-CONOTOXINS; PATCH-CLAMP TECHNIQUES; PEPTIDES; RATS; RATS, WISTAR;

EID: 23044455421     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706223     Document Type: Article

References (51)

1. ADAMS, D.J., SMITH, A.B., SCHROEDER, C.I., YASUDA, T. & LEWIS, R.J. (2003). ω-Conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. J. Biol. Chem., 278, 4057-4062.
2. BANKER, G.A. & COWAN, W.M. (1979). Further observations on hippocampal neurons in dispersed cell culture. J. Comp. Neurol., 187, 469-493.
3. BLALOCK, E.M., PORTER, N.M. & LANDFIELD, P.W. (1999). Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures. J. Neurosci., 19, 8674-8684.
4. BOWERSOX, S.S., MILJANICH, G.P., SUGIURA, Y., LI, C., NADASDI, L., HOFFMAN, B.B., RAMACHANDRAN, J. & KO, C.P. (1995). Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel ω-conopeptides and ω-agatoxin-IVA. J. Pharmacol. Exp. Ther., 273, 248-256.
5. BOWERSOX, S.S., SINGH, T. & LUTHER, R.R. (1997). Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats. Brain Res., 747, 343-347.
6. BULAJ, G., DELACRUZ, R., AZIMI-ZONOOZ, A., WEST, P., WATKINS, M., YOSHIKAMI, D. & OLIVERA, B.M. (2001). Conotoxin structure/function through a cladistic analysis. Biochemistry, 40, 13201-13208.
7. CURRIE, K.P.M. & FOX, A.P. (1997). Comparison of N- and P/Q-type voltage-gated calcium channel current inhibition. J. Neurosci., 17, 4570-4579.
8. DAI, Q., LIU, F., ZHOU, Y., LU, B., YU, F. & HUANG, P. (2003). The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus. J. Nat. Prod., 66, 1276-1279.
9. DOGGRELL, S.A. (2004). Intrathecal ziconotide for refractory pain. Expert Opin. Investig. Drugs, 13, 875-877.
10. FENG, Z.P., DOERING, C.J., WINKFEIN, R.J., BEEDLE, A.M., SPAFFORD, J.D. & ZAMPONI, G.W. (2003). Determinants of inhibition of transiently expressed voltage-gated calcium channels by ω-conotoxins GVIA and MVIIA. J. Biol. Chem., 278, 20171-20178.
11. 1B subunit controls reversibility of ω-conotoxin GVIA and MVIIA block. J. Biol. Chem., 276, 15728-15735.
12. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
13. 2+ channels. Neuroreport, 12, 2423-2427.
14. 2+ channels. Neuron, 9, 69-77.
15. 2+ channels, cytoplasmic messengers and proteins of the synaptic vesicle release complex. Trends Pharmacol. Sci., 22, 519-525.
16. 2+ channel blocker neurotoxins on transmitter release and presynaptic currents at the mouse neuromuscular junction. Br. J. Pharmacol., 121, 1531-1540.
17. 1B subunit of the voltage-dependent calcium channel. Mol. Cell Neurosci., 18, 235-245.
18. KIM, J.I., TAKAHASHI, M., OHTAKE, A., WAKAMIYA, A. & SATO, K. (1995). Tyr13 is essential for the activity of ω-conotoxin mviia and gvia, specific N-type calcium channel blockers. Biochem. Biophys. Res. Commun., 206, 449-454.
19. KRISTIPATI, R., NADASDI, L., TARCZY-HORNOCH, K., LAU, K., MILJANICH, G.P., RAMACHANDRAN, J. & BELL, J.R. (1994). Characterization of the binding of ω-Conopeptides to different classes of non-L-type neuronal calcium channels. Mol. Cell Neurosci., 5, 219-228.
20. LEW, M.J., FLINN, J.P., PALLAGHY, P.K., MURPHY, R., WHORLOW, S.L., WRIGHT, C.E., NORTON, R.S. & ANGUS, J.A. (1997). Structure-function relationships of ω-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogs. J. Biol. Chem., 272, 12014-12023.
21. LEWIS, R.J., NIELSEN, K.J., CRAIK, D.J., LOUGHNAN, M.L., ADAMS, D.A., SHARPE, I.A., LUCHIAN, T., ADAMS, D.J., BOND, T., THOMAS, L., JONES, A., MATHESON, J.L., DRINKWATER, R., ANDREWS, P.R. & ALEWOOD, P.F. (2000). Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J. Biol. Chem., 275, 35335-35344.
22. v 2.2) by ω-conotoxin GVIA in the absence of divalent cations. J. Neurosci., 22, 8884-8890.
23. 2+ channel in rat sympathetic ganglia and brain. Neuron, 18, 153-166.
24. LU, B.S., YU, F., ZHAO, D., HUANG, P.T. & HUANG, C.F. (1999). Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides, 20, 1139-1144.
25. MCINTOSH, J.M., HASSON, A., SPIRA, M.E., GRAY, W.R., LI, W., MARSH, M., HILLYARD, D.R. & OLIVERA, B.M. (1995). A new family of conotoxins that blocks voltage-gated sodium channels. J. Biol. Chem., 270, 16796-16802.
26. MEIR, A., GINSBURG, S., BUTKEVICH, A., KACHALSKY, S.G., KAISERMAN, I., AHDUT, R., DEMIRGOREN, S. & RAHAMIMOFF, R. (1999). Ion channels in presynaptic nerve terminals and control of transmitter release. Physiol. Rev., 79, 1019-1088.
27. v2.2) calcium channels. J. Biol. Chem., 279, 34705-34714.
28. 2+ current in hippocampal and dorsal root ganglion neurons of the rat. Mol. Pharmacol., 54, 559-568.
29. NEWCOMB, R., SZOKE, B., PALMA, A., WANG, G., CHEN, X.H., HOPKINS, W., CONG, R., MILLER, J., URGE, L., TARCZY-HORNOCH, K., LOO, J.A., DOOLEY, D.J., NADASDI, L., TSIEN, R.W., LEMOS, J. & MILJANICH, G. (1998). Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry, 37, 15353-15362.
30. NIELSEN, K.J., ADAMS, D., THOMAS, L., BOND, T., ALEWOOD, P.F., CRAIK, D.J. & LEWIS, R.J. (1999a). Structure-activity relationships of ω-conotoxins MVIIA, MVIIC and 1, 4 loop splice hybrids at N and P/Q-type calcium channels. J. Mol. Biol., 289, 1405-1421.
31. 13 on the structure-activity relationships of ω-conotoxins from conus magus. Biochemistry, 38, 6741-6751.
32. NIELSEN, K.J., SCHROEDER, T. & LEWIS, R. (2000). Structure-activity relationships of ω-conotoxins at N-type voltage-sensitive calcium channels. J. Mol. Recognit., 13, 55-70.
33. OLIVERA, B.M. & CRUZ, L.J. (2001). Conotoxins, in retrospect. Toxicon, 39, 7-14.
34. OLIVERA, B.M., MCINTOSH, J.M., CRUZ, L.J., LUQUE, F.A. & GRAY, W.R. (1984). Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry, 23, 5087-5090.
35. PRINGLE, A.K., BENHAM, C.D., SIM, L., KENNED, Y.J., IANNOTTI, F. & SUNDSTROM, L.E. (1996). Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures. Stroke, 27, 2124-2130.
36. RAMILO, C.A., ZAFARALLA, G.C., NADASDI, L., HAMMERLAND, L.G., YOSHIKAMI, D., GRAY, W.R., KRISTIPATI, R., RAMACHANDRAN, J., MILJANICH, G. & OLIVERA, B.M. (1992). Novel α- and ω-conotoxins from Conus striatus venom. Biochemistry, 31, 9919-9926.
37. 2+ channels on pain transmission. Neurosci. Res., 43, 1-7.
38. SCAMPS, F., VIGUES, S., RESTITUITO, S., CAMPO, B., ROIG, A., CHARNET, P. & VALMIER, J. (2000). Sarco-endoplasmic ATPase blocker 2, 5-di (tert-butyl)-1, 4-benzohydroquinone inhibits N-, P-, and Q- but not T-, L-, or R-type calcium currents in central and peripheral neurons. Mol. Pharmacol., 58, 18-26.
39. SCOTT, D.A., WRIGHT, C.E. & ANGUS, J.A. (2002). Actions of intrathecal ω-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur. J. Pharmacol., 451, 279-286.
40. + channel. J. Biol. Chem., 273, 33-38.
41. SMITH, M.T., CABOT, P.J., ROSS, F.B., ROBERTSON, A.D. & LEWIS, R.J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain, 96, 119-127.
42. STAATS, P.S., YEARWOOD, T., CHARAPATA, S.G., PRESLEY, R.W., WALLACE, M.S., BYAS-SMITH, M., FISHER, R., BRYCE, D.A., MANGIERI, E.A., LUTHER, R.R., MAYO, M., MCGUIRE, D. & ELLIS, D. (2004). Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA, 291, 63-70.
43. 2+ channels. J. Neurosci., 17, 3002-3013.
44. TERLAU, H. & OLIVERA, B.M. (2004). Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol. Rev., 84, 41-68.
45. VANEGASA, H. & SCHAIBLE, H.G. (2000). Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain, 8, 9-18.
46. WILLIAMS, M.E., BRUST, P.F., FELDMAN, D.H., PATTHI, S., SIMERSON, S., MAROUFI, A., MCCUE, A.F., VELICELEBI, G., ELLIS, S.B. & HARPOLD, M.M. (1992a). Structure and functional expression of an ω-conotoxin-sensitive human N-type calcium channel. Science, 257, 389-395.
47. WILLIAMS, M.E., FELDMAN, D.H., MCCUE, A.F., BRENNER, R., VELICELEBI, G., ELLIS, S.B. & HARPOLD, M.M. (1992b). Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype. Neuron, 8, 71-84.
48. 1HNMR. Chin. Sci. Bull., 48, 1097-1102.
49. + channels in midbrain dopaminergic neurons. Nat. Neurosci., 4, 1071-1078.
50. ZAMPONI, G.W. (2003). Regulation of presynaptic calcium channels by synaptic proteins. J. Pharmacol. Sci., 92, 79-83.
51. 2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology, 32, 1075-1088.