Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats

Brain Research

Volumn 747, Issue 2, 1997, Pages 343-347

  Bowersox, S Scott ^a   Singh, Tejinder ^a   Luther, Robert R ^a  

^a Neurex Corporation   (United States)

Author keywords

calcium channel; calcium channel blocker; conopeptide; focal ischemia; neuroprotection

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; NEUROPROTECTIVE AGENT; OMEGA CONOTOXIN MVIIA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BRAIN DAMAGE, CHRONIC; CALCIUM CHANNEL BLOCKERS; DRUG EVALUATION, PRECLINICAL; HYPERTENSION; ISCHEMIC ATTACK, TRANSIENT; MALE; MEMBRANE POTENTIALS; MOLLUSK VENOMS; NEUROPROTECTIVE AGENTS; OMEGA-CONOTOXINS; PEPTIDES; RATS; RATS, INBRED SHR;

EID: 0031039720     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01325-X     Document Type: Article

References (32)

1. Bowersox, S.S., Singh, T., Nadasdi, L., Zukowska-Grojec, Z., Valentino, K. and Hoffman, B.B., Cardiovascular effects of ω-conopeptides in conscious rats: mechanism of action, J. Cardiovasc. Pharmacol., 20 (1992) 756-764.
2. Bowersox, S.S., Crea, R., Gadbois, T., Goddard, P., Gohil, K., Luther, R.R., Miljanich, G., Singh, T. and Xue, D., Selective N-type voltage sensitive calcium channel (VSCC) blockers: a new class of therapeutic agent targeted for the treatment of ischemia-induced brain damage, 18th Annual Meeting, European Neuroscience Association Abstr. (1995) 25.
3. Brint, S., Jacewicz, M., Kiessling, M., Tanabe, J. and Pulsinelli, W.A., Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries, J. Cereb. Blood Flow Metab., 8 (1988) 474-485.
4. Buchan, A., Xue, D. and Slivka, A., A new model of temporary focal neocortical ischemia in the rat, Stroke, 23 (1992) 273-279.
5. 2+ blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia, J. Cereb. Blood Flow Metab., 14 (1994) 903-910.
6. Choi, D.W., Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage, Trends Neurosci., 11 (1988) 465-469.
7. Choi, D.W., Calcium: still center-stage in hypoxic-ischemic neuronal death, Trends Neurosci., 18 (1995) 58-60.
8. Clasbrummel, B., Osswald, H. and Illes, P., Inhibition of noradrenaline release by ω-conotoxin GVIA in the rat tail artery, Br. J. Pharmacol., 96 (1989) 355-362.
9. 2+ channels in mammalian central neurons, Trends Neurosci., 18 (1995) 89-98.
10. Hillyard, D.R., Monje, V.D., Mintz, I.M., Bean, B.P., Nadasdi, L., Ramachandran, J., Miljanich, G., Azimi-Zoonooz, A., McIntosh, J.M., Cruz, L., Imperial, J.S. and Olivera, B.M., A new Conus peptide ligand for mammalian presynaptic calcium channels, Neuron, 9 (1992) 69-77.
11. Kristipati, R., Nadasdi, L., Tarczy-Hornoch, K., Lau, K., Miljanich, G.P., Ramachandran, R. and Bell, J.R., Characterization of the binding of omega-conopeptides to different classes of non-L-type neuronal calcium channels, Mol. Cell Neurosci., 5 (1994) 219-228.
12. Kunis, D.M., Perez-Pinzón, M.A., Sun, G.H. and Steinberg, G.K., SNX-111. a novel N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits, Soc. Neurosci. Abstr., 20 (1994) 184.
13. Ohta, S., Smith, M.L. and Siesjö, B.K., The effect of a dihydropyridine calcium channel antagonist (isradipine) on selective neuronal necrosis, J. Neurol. Sci., 103 (1989) 109-115.
14. Olivera, B.M., Cruz, L.J., de Santos, V., Le Cheminant, G.W., Griffin, D., Zeilcus, R., McIntosh, J.M., Galyean, R., Varga, J., Gray, W.R. and Rivier, J., Neuronal calcium channel subtypes using ω-conotoxin from Conus magus venom, Biochemistry, 26 (1987) 2086-2090.
15. Olivera, B.M., Miljanich, G.P., Ramachandran, J. and Adams, M.E., Calcium channel diversity and neurotransmitter release: the ω-conotoxins and ω-agatoxins, Annu. Rev. Biochem., 63 (1994) 823-867.
16. Peters, T., Calcium in physiological and pathological cell function, Eur. Neurol., 25 (1986) 27-44.
17. Pickard, J.D., Murray, G.D., Illingworth, R., Shaw, M.D., Teasdale, G.M., Foy, P.M., Humphrey, P.R., Lang, D.A., Nelson, R., Richards, P., et al., Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial, Br. Med. J., 298 (1989) 636-642.
18. Pruneau, D. and Angus, J.A., Apparent vascular to cardiac sympatholytic selectivity of ω-conotoxin GVIA in the pithed rat, Eur. J. Pharmacol., 184 (1990) 127-133.
19. Siesjö, B.K., Calcium and ischemic brain damage, Eur. Neurol., 25 (1986) 45-56.
20. Siesjö, B.K., Cell damage in the brain: a speculative synthesis, J. Cereb. Blood Flow Metab., 1 (1981) 155-185.
21. Siesjö, B.K., Historical overview. Calcium, ischemia, and death of brain cells, Ann. NY Acad. Sci., 522 (1988) 638-661.
22. Siesjö, B.K., Katsura, K., Pahlmark, K. and Smith, M.-L., The multiple causes of ischemic cell death: a speculative synthesis, In J. Krieglstein and H. Oberpichler-Schwenk (Eds.), Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlag, Stuttgart, 1992, pp. 511-525.
23. 2+] in hypoxia and ischemia in rat brain in vivo, J. Gen. Physiol., 95 (1990) 837-866.
24. Smith, M.-L. and Siesjö, B.K., Postischemic treatment with omega-conopeptide SNX-111 protects the rat brain against ischemic damage, In J. Krieglstein and H. Oberpilcher-Schwenk (Eds.), Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlag, Stuttgart, 1992, pp. 161-167.
25. Steen, P.A., Newberg, L.A., Milde, J.H. and Michenfelder, J.D., Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischemia in the dog, J. Cereb. Blood Flow Metab., 4 (1984) 82-87.
26. Takizawa, S., Matsushima, K., Fujita, H., Nanri, K., Ogawa, S. and Shinohara, Y., A selective N-type calcium antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischemia, J. Cereb. Blood Flow Metab., 15 (1995) 611-618.
27. Valentino, K., Newcomb, R., Gadbois, T., Singh, T., Bowersox, S., Bitner, S., Justice, A., Yamashiro, D., Hoffman, B.B., Ciaranello, R., Miljanich, G. and Ramachandran, J., A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia, Proc. Natl. Acad. Sci., USA, 90 (1993) 7894-7897.
28. 2+ entry blockers, Ann. NY Acad. Sci., 522 (1994) 478-490, 1988.
29. Xue, D., Huang, Z.-G., Smith, K.E. and Buchan, A.M., Immediate or delayed mild hypothermia prevents focal cerebral infarction, Brain Res., 587 (1992) 66-72.
30. Yamada, K., Teraoka, T., Monta, S., Hasegawa, T. and Nabeshima, T., Omega-conotoxin GVIA protects against ischemia-induced neuronal death in the Mongolian gerbil but not against quinolinic acid-induced neurotoxicity in the rat, Neuropharmacology, 33 (1994) 251-254.
31. Yamashiro, D. and Li, C.H., New segment synthesis of alpha-inhibin-92 by the acyl disulfide method, Int. J. Peptide Protein Res., 31 (1988) 322-334.
32. Zhao, Q., Smith, M.-L. and Siesjö, B.K., The omega-conopeptide, SNX-111, an N-type calcium channel blocker, dramatically ameliorates brain damage due to transient focal ischemia, Acta Physiol. Scand., 150 (1994) 459-461.